SRF
Summary: This gene encodes a ubiquitous nuclear protein that stimulates both cell proliferation and differentiation. It is a member of the MADS (MCM1, Agamous, Deficiens, and SRF) box superfamily of transcription factors. This protein binds to the serum response element (SRE) in the promoter region of target genes. This protein regulates the activity of many immediate-early genes, for example c-fos, and thereby participates in cell cycle regulation, apoptosis, cell growth, and cell differentiation. This gene is the downstream target of many pathways; for example, the mitogen-activated protein kinase pathway (MAPK) that acts through the ternary complex factors (TCFs). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2014].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| serum response factor | MIM:600589 | Ensembl:ENSG00000112658 | HGNC:HGNC:11291 | PA36116 | 6p21.1 |
Gene Categories:
TRANSCRIPTION FACTOR BINDINGGO terms in SRF
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0000976 | transcription regulatory region sequence-specific DNA binding |
| MF | IBA | GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding |
| MF | ISS | GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding |
| MF | ISM | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | NAS | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | IBA | GO:0000982 | transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding |
| MF | IMP | GO:0000983 | transcription factor activity, RNA polymerase II core promoter sequence-specific DNA binding |
| MF | IEA | GO:0001076 | transcription factor activity, RNA polymerase II transcription factor binding |
| MF | IDA | GO:0001077 | transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding |
| MF | IEA | GO:0001085 | RNA polymerase II transcription factor binding |
| MF | ISS | GO:0001228 | transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding |
| MF | IDA | GO:0003700 | DNA-binding transcription factor activity |
| MF | IEA | GO:0003705 | transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IBA | GO:0008134 | transcription factor binding |
| MF | IPI | GO:0008134 | transcription factor binding |
| MF | IDA | GO:0010736 | serum response element binding |
| MF | IEA | GO:0031490 | chromatin DNA binding |
| MF | IPI | GO:0042803 | protein homodimerization activity |
| MF | IEA | GO:0042826 | histone deacetylase binding |
| MF | IBA | GO:0043565 | sequence-specific DNA binding |
| MF | IBA | GO:0044212 | transcription regulatory region DNA binding |
| MF | ISS | GO:0070878 | primary miRNA binding |
| BP | IEA | GO:0001569 | branching involved in blood vessel morphogenesis |
| BP | IEP | GO:0001666 | response to hypoxia |
| BP | IEA | GO:0001707 | mesoderm formation |
| BP | IEA | GO:0001764 | neuron migration |
| BP | IDA | GO:0001829 | trophectodermal cell differentiation |
| BP | ISS | GO:0001947 | heart looping |
| BP | IEA | GO:0002011 | morphogenesis of an epithelial sheet |
| BP | IMP | GO:0002042 | cell migration involved in sprouting angiogenesis |
| BP | IGI | GO:0003257 | positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation |
| BP | IDA | GO:0006366 | transcription by RNA polymerase II |
| BP | IEA | GO:0007160 | cell-matrix adhesion |
| BP | IBA | GO:0007275 | multicellular organism development |
| BP | ISS | GO:0007507 | heart development |
| BP | IEA | GO:0007616 | long-term memory |
| BP | IEA | GO:0008285 | negative regulation of cell proliferation |
| BP | IEA | GO:0008306 | associative learning |
| BP | TAS | GO:0009636 | response to toxic substance |
| BP | IDA | GO:0009725 | response to hormone |
| BP | IEA | GO:0010669 | epithelial structure maintenance |
| BP | IDA | GO:0010735 | positive regulation of transcription via serum response element binding |
| BP | IEA | GO:0021766 | hippocampus development |
| BP | IEA | GO:0022028 | tangential migration from the subventricular zone to the olfactory bulb |
| BP | IEA | GO:0030155 | regulation of cell adhesion |
| BP | IEA | GO:0030168 | platelet activation |
| BP | IEA | GO:0030220 | platelet formation |
| BP | IEA | GO:0030336 | negative regulation of cell migration |
| BP | IEA | GO:0030878 | thyroid gland development |
| BP | IEA | GO:0031175 | neuron projection development |
| BP | IEA | GO:0033561 | regulation of water loss via skin |
| BP | IMP | GO:0034097 | response to cytokine |
| BP | NAS | GO:0034097 | response to cytokine |
| BP | IEA | GO:0035855 | megakaryocyte development |
| BP | IEA | GO:0035912 | dorsal aorta morphogenesis |
| BP | ISS | GO:0042789 | mRNA transcription by RNA polymerase II |
| BP | IEA | GO:0043149 | stress fiber assembly |
| BP | IEA | GO:0043589 | skin morphogenesis |
| BP | IEA | GO:0045059 | positive thymic T cell selection |
| BP | IEA | GO:0045214 | sarcomere organization |
| BP | IDA | GO:0045597 | positive regulation of cell differentiation |
| BP | IEA | GO:0045773 | positive regulation of axon extension |
| BP | IDA | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IDA | GO:0045987 | positive regulation of smooth muscle contraction |
| BP | IEA | GO:0046016 | positive regulation of transcription by glucose |
| BP | ISS | GO:0046716 | muscle cell cellular homeostasis |
| BP | IEA | GO:0048538 | thymus development |
| BP | IEA | GO:0048589 | developmental growth |
| BP | TAS | GO:0048666 | neuron development |
| BP | IEA | GO:0048821 | erythrocyte development |
| BP | IDA | GO:0051091 | positive regulation of DNA-binding transcription factor activity |
| BP | TAS | GO:0051150 | regulation of smooth muscle cell differentiation |
| BP | IEA | GO:0051491 | positive regulation of filopodium assembly |
| BP | IEA | GO:0055003 | cardiac myofibril assembly |
| BP | TAS | GO:0060055 | angiogenesis involved in wound healing |
| BP | IEA | GO:0060218 | hematopoietic stem cell differentiation |
| BP | IDA | GO:0060261 | positive regulation of transcription initiation from RNA polymerase II promoter |
| BP | IEA | GO:0060292 | long term synaptic depression |
| BP | IEA | GO:0060324 | face development |
| BP | IEA | GO:0060347 | heart trabecula formation |
| BP | IEA | GO:0060425 | lung morphogenesis |
| BP | IEA | GO:0060532 | bronchus cartilage development |
| BP | IEA | GO:0060534 | trachea cartilage development |
| BP | IEA | GO:0060947 | cardiac vascular smooth muscle cell differentiation |
| BP | IEA | GO:0061029 | eyelid development in camera-type eye |
| BP | IEA | GO:0061145 | lung smooth muscle development |
| BP | IEA | GO:0070830 | bicellular tight junction assembly |
| BP | IEA | GO:0071333 | cellular response to glucose stimulus |
| BP | IEA | GO:0090009 | primitive streak formation |
| BP | IEA | GO:0090136 | epithelial cell-cell adhesion |
| BP | IMP | GO:0090398 | cellular senescence |
| BP | IMP | GO:1900222 | negative regulation of amyloid-beta clearance |
| BP | ISS | GO:1902894 | negative regulation of pri-miRNA transcription by RNA polymerase II |
| BP | ISS | GO:1902895 | positive regulation of pri-miRNA transcription by RNA polymerase II |
| CC | IEA | GO:0000790 | nuclear chromatin |
| CC | IBA | GO:0005634 | nucleus |
| CC | IDA | GO:0005634 | nucleus |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | TAS | GO:0005737 | cytoplasm |
Gene expression in normal tissue: SRF
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in SRF
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP1591 | Heart Development |
| wikipathways | WP1991 | SRF and miRs in Smooth Muscle Differentiation and Proliferation |
| wikipathways | WP1992 | TarBasePathway |
| wikipathways | WP2005 | miR-targeted genes in muscle cell - TarBase |
| wikipathways | WP2012 | miRs in Muscle Cell Differentiation |
| wikipathways | WP2023 | Cell Differentiation - Index expanded |
| wikipathways | WP2029 | Cell Differentiation - Index |
| wikipathways | WP2857 | Mesodermal Commitment Pathway |
| wikipathways | WP382 | MAPK Signaling Pathway |
| wikipathways | WP3888 | VEGFA-VEGFR2 Signaling Pathway |
| wikipathways | WP3972 | PDGFR-beta pathway |
| wikipathways | WP481 | Insulin Signaling |
| wikipathways | WP722 | Serotonin HTR1 Group and FOS Pathway |
| wikipathways | WP732 | Serotonin Receptor 2 and ELK-SRF-GATA4 signaling |
| wikipathways | WP734 | Serotonin Receptor 4-6-7 and NR3C Signaling |
| kegg | hsa04010 | MAPK signaling pathway - Homo sapiens (human) |
| kegg | hsa04022 | cGMP-PKG signaling pathway - Homo sapiens (human) |
| kegg | hsa05166 | HTLV-I infection - Homo sapiens (human) |
| kegg | hsa05203 | Viral carcinogenesis - Homo sapiens (human) |
| pid | ar_pathway | Coregulation of Androgen receptor activity |
| pid | erbb1_downstream_pathway | ErbB1 downstream signaling |
| pid | hdac_classii_pathway | Signaling events mediated by HDAC Class II |
| pid | mapktrkpathway | Trk receptor signaling mediated by the MAPK pathway |
| pid | p38_mk2pathway | p38 signaling mediated by MAPKAP kinases |
| pid | pdgfrapathway | PDGFR-alpha signaling pathway |
| pid | pdgfrbpathway | PDGFR-beta signaling pathway |
| pid | rhoa_pathway | RhoA signaling pathway |
| biocarta | ghpathway | growth hormone signaling pathway |
| biocarta | hoppathway | hop pathway in cardiac development |
| biocarta | igf1pathway | igf-1 signaling pathway |
| biocarta | malpathway | role of mal in rho-mediated activation of srf |
| biocarta | pdgfpathway | pdgf signaling pathway |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-194315 | Signaling by Rho GTPases |
| reactome | R-HSA-195258 | RHO GTPase Effectors |
| reactome | R-HSA-5663220 | RHO GTPases Activate Formins |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD103 | SN-38 | 3 |
| iGMDRD782 | DC-45-A2 | 3 |
| iGMDRD705 | Nakiterpiosin | 3 |
| iGMDRD577 | BIX01294 | 3 |
| iGMDRD345 | Compound 10b [PMID: 11504634] | 3 |
| iGMDRD150 | RITA | 1 |
| iGMDRD701 | NVP-AUY922 | 2 |
| iGMDRD79 | Gemcitabine | 1 |
| iGMDRD483 | SCH-529074 | 3 |
| iGMDRD85 | Ursolic acid | 1 |
| iGMDRD177 | Teniposide | 3 |
| iGMDRD123 | Isoevodiamine | 3 |
| iGMDRD280 | CYTOCHALASIN B | 6 |
| iGMDRD466 | Chaetocin | 3 |
| iGMDRD679 | Bistramide A | 1 |
| iGMDRD375 | GW-405833 | 3 |
| iGMDRD634 | SCHEMBL2608041 | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in SRF
CLASSFICATION
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