SRF
Summary: This gene encodes a ubiquitous nuclear protein that stimulates both cell proliferation and differentiation. It is a member of the MADS (MCM1, Agamous, Deficiens, and SRF) box superfamily of transcription factors. This protein binds to the serum response element (SRE) in the promoter region of target genes. This protein regulates the activity of many immediate-early genes, for example c-fos, and thereby participates in cell cycle regulation, apoptosis, cell growth, and cell differentiation. This gene is the downstream target of many pathways; for example, the mitogen-activated protein kinase pathway (MAPK) that acts through the ternary complex factors (TCFs). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2014].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:600589 Ensembl IDEnsembl:ENSG00000112658 HGNC IDHGNC:HGNC:11291 PHARMGKB IDPA36116 Map Location6p21.1 | |||||
Gene Categories:
TRANSCRIPTION FACTOR BINDINGGO terms in SRF
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0000976 | transcription regulatory region sequence-specific DNA binding |
| MF | IBA | GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding |
| MF | ISS | GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding |
| MF | ISM | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | NAS | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | IBA | GO:0000982 | transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding |
Gene expression in normal tissue: SRF
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in SRF
Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP1591 | Heart Development |
| wikipathways | WP1991 | SRF and miRs in Smooth Muscle Differentiation and Proliferation |
| wikipathways | WP1992 | TarBasePathway |
| wikipathways | WP2005 | miR-targeted genes in muscle cell - TarBase |
| wikipathways | WP2012 | miRs in Muscle Cell Differentiation |
| wikipathways | WP2023 | Cell Differentiation - Index expanded |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in SRF
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
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