SRF


Summary: This gene encodes a ubiquitous nuclear protein that stimulates both cell proliferation and differentiation. It is a member of the MADS (MCM1, Agamous, Deficiens, and SRF) box superfamily of transcription factors. This protein binds to the serum response element (SRE) in the promoter region of target genes. This protein regulates the activity of many immediate-early genes, for example c-fos, and thereby participates in cell cycle regulation, apoptosis, cell growth, and cell differentiation. This gene is the downstream target of many pathways; for example, the mitogen-activated protein kinase pathway (MAPK) that acts through the ternary complex factors (TCFs). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2014].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
serum response factorMIM:600589Ensembl:ENSG00000112658HGNC:HGNC:11291PA361166p21.1

GO terms in SRF


Term TypeEvidence TypeGO Term IDGO Des.
MFIBAGO:0000976transcription regulatory region sequence-specific DNA binding
MFIBAGO:0000977RNA polymerase II regulatory region sequence-specific DNA binding
MFISSGO:0000978RNA polymerase II proximal promoter sequence-specific DNA binding
MFISMGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFNASGO:0000981RNA polymerase II transcription factor activity, sequence-specific DNA binding
MFIBAGO:0000982transcription factor activity, RNA polymerase II proximal promoter sequence-specific DNA binding
MFIMPGO:0000983transcription factor activity, RNA polymerase II core promoter sequence-specific DNA binding
MFIEAGO:0001076transcription factor activity, RNA polymerase II transcription factor binding
MFIDAGO:0001077transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding
MFIEAGO:0001085RNA polymerase II transcription factor binding
MFISSGO:0001228transcriptional activator activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding
MFIDAGO:0003700DNA-binding transcription factor activity
MFIEAGO:0003705transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding
MFIPIGO:0005515protein binding
MFIBAGO:0008134transcription factor binding
MFIPIGO:0008134transcription factor binding
MFIDAGO:0010736serum response element binding
MFIEAGO:0031490chromatin DNA binding
MFIPIGO:0042803protein homodimerization activity
MFIEAGO:0042826histone deacetylase binding
MFIBAGO:0043565sequence-specific DNA binding
MFIBAGO:0044212transcription regulatory region DNA binding
MFISSGO:0070878primary miRNA binding
BPIEAGO:0001569branching involved in blood vessel morphogenesis
BPIEPGO:0001666response to hypoxia
BPIEAGO:0001707mesoderm formation
BPIEAGO:0001764neuron migration
BPIDAGO:0001829trophectodermal cell differentiation
BPISSGO:0001947heart looping
BPIEAGO:0002011morphogenesis of an epithelial sheet
BPIMPGO:0002042cell migration involved in sprouting angiogenesis
BPIGIGO:0003257positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation
BPIDAGO:0006366transcription by RNA polymerase II
BPIEAGO:0007160cell-matrix adhesion
BPIBAGO:0007275multicellular organism development
BPISSGO:0007507heart development
BPIEAGO:0007616long-term memory
BPIEAGO:0008285negative regulation of cell proliferation
BPIEAGO:0008306associative learning
BPTASGO:0009636response to toxic substance
BPIDAGO:0009725response to hormone
BPIEAGO:0010669epithelial structure maintenance
BPIDAGO:0010735positive regulation of transcription via serum response element binding
BPIEAGO:0021766hippocampus development
BPIEAGO:0022028tangential migration from the subventricular zone to the olfactory bulb
BPIEAGO:0030155regulation of cell adhesion
BPIEAGO:0030168platelet activation
BPIEAGO:0030220platelet formation
BPIEAGO:0030336negative regulation of cell migration
BPIEAGO:0030878thyroid gland development
BPIEAGO:0031175neuron projection development
BPIEAGO:0033561regulation of water loss via skin
BPIMPGO:0034097response to cytokine
BPNASGO:0034097response to cytokine
BPIEAGO:0035855megakaryocyte development
BPIEAGO:0035912dorsal aorta morphogenesis
BPISSGO:0042789mRNA transcription by RNA polymerase II
BPIEAGO:0043149stress fiber assembly
BPIEAGO:0043589skin morphogenesis
BPIEAGO:0045059positive thymic T cell selection
BPIEAGO:0045214sarcomere organization
BPIDAGO:0045597positive regulation of cell differentiation
BPIEAGO:0045773positive regulation of axon extension
BPIDAGO:0045944positive regulation of transcription by RNA polymerase II
BPIDAGO:0045987positive regulation of smooth muscle contraction
BPIEAGO:0046016positive regulation of transcription by glucose
BPISSGO:0046716muscle cell cellular homeostasis
BPIEAGO:0048538thymus development
BPIEAGO:0048589developmental growth
BPTASGO:0048666neuron development
BPIEAGO:0048821erythrocyte development
BPIDAGO:0051091positive regulation of DNA-binding transcription factor activity
BPTASGO:0051150regulation of smooth muscle cell differentiation
BPIEAGO:0051491positive regulation of filopodium assembly
BPIEAGO:0055003cardiac myofibril assembly
BPTASGO:0060055angiogenesis involved in wound healing
BPIEAGO:0060218hematopoietic stem cell differentiation
BPIDAGO:0060261positive regulation of transcription initiation from RNA polymerase II promoter
BPIEAGO:0060292long term synaptic depression
BPIEAGO:0060324face development
BPIEAGO:0060347heart trabecula formation
BPIEAGO:0060425lung morphogenesis
BPIEAGO:0060532bronchus cartilage development
BPIEAGO:0060534trachea cartilage development
BPIEAGO:0060947cardiac vascular smooth muscle cell differentiation
BPIEAGO:0061029eyelid development in camera-type eye
BPIEAGO:0061145lung smooth muscle development
BPIEAGO:0070830bicellular tight junction assembly
BPIEAGO:0071333cellular response to glucose stimulus
BPIEAGO:0090009primitive streak formation
BPIEAGO:0090136epithelial cell-cell adhesion
BPIMPGO:0090398cellular senescence
BPIMPGO:1900222negative regulation of amyloid-beta clearance
BPISSGO:1902894negative regulation of pri-miRNA transcription by RNA polymerase II
BPISSGO:1902895positive regulation of pri-miRNA transcription by RNA polymerase II
CCIEAGO:0000790nuclear chromatin
CCIBAGO:0005634nucleus
CCIDAGO:0005634nucleus
CCTASGO:0005654nucleoplasm
CCTASGO:0005737cytoplasm

Gene expression in normal tissue: SRF

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in SRF


DatabasePathway IDPathway Des.
wikipathwaysWP1591Heart Development
wikipathwaysWP1991SRF and miRs in Smooth Muscle Differentiation and Proliferation
wikipathwaysWP1992TarBasePathway
wikipathwaysWP2005miR-targeted genes in muscle cell - TarBase
wikipathwaysWP2012miRs in Muscle Cell Differentiation
wikipathwaysWP2023Cell Differentiation - Index expanded
wikipathwaysWP2029Cell Differentiation - Index
wikipathwaysWP2857Mesodermal Commitment Pathway
wikipathwaysWP382MAPK Signaling Pathway
wikipathwaysWP3888VEGFA-VEGFR2 Signaling Pathway
wikipathwaysWP3972PDGFR-beta pathway
wikipathwaysWP481Insulin Signaling
wikipathwaysWP722Serotonin HTR1 Group and FOS Pathway
wikipathwaysWP732Serotonin Receptor 2 and ELK-SRF-GATA4 signaling
wikipathwaysWP734Serotonin Receptor 4-6-7 and NR3C Signaling
kegghsa04010MAPK signaling pathway - Homo sapiens (human)
kegghsa04022cGMP-PKG signaling pathway - Homo sapiens (human)
kegghsa05166HTLV-I infection - Homo sapiens (human)
kegghsa05203Viral carcinogenesis - Homo sapiens (human)
pidar_pathwayCoregulation of Androgen receptor activity
piderbb1_downstream_pathwayErbB1 downstream signaling
pidhdac_classii_pathwaySignaling events mediated by HDAC Class II
pidmapktrkpathwayTrk receptor signaling mediated by the MAPK pathway
pidp38_mk2pathwayp38 signaling mediated by MAPKAP kinases
pidpdgfrapathwayPDGFR-alpha signaling pathway
pidpdgfrbpathwayPDGFR-beta signaling pathway
pidrhoa_pathwayRhoA signaling pathway
biocartaghpathwaygrowth hormone signaling pathway
biocartahoppathwayhop pathway in cardiac development
biocartaigf1pathwayigf-1 signaling pathway
biocartamalpathwayrole of mal in rho-mediated activation of srf
biocartapdgfpathwaypdgf signaling pathway
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-194315Signaling by Rho GTPases
reactomeR-HSA-195258RHO GTPase Effectors
reactomeR-HSA-5663220RHO GTPases Activate Formins

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD103SN-383
iGMDRD782DC-45-A23
iGMDRD705Nakiterpiosin3
iGMDRD577BIX012943
iGMDRD345Compound 10b [PMID: 11504634]3
iGMDRD150RITA1
iGMDRD701NVP-AUY9222
iGMDRD79Gemcitabine1
iGMDRD483SCH-5290743
iGMDRD85Ursolic acid1
iGMDRD177Teniposide3
iGMDRD123Isoevodiamine3
iGMDRD280CYTOCHALASIN B6
iGMDRD466Chaetocin3
iGMDRD679Bistramide A1
iGMDRD375GW-4058333
iGMDRD634SCHEMBL26080413

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in SRF

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