STRADA
Summary: The protein encoded by this gene contains a STE20-like kinase domain, but lacks several residues that are critical for catalytic activity, so it is termed a 'pseudokinase'. The protein forms a heterotrimeric complex with serine/threonine kinase 11 (STK11, also known as LKB1) and the scaffolding protein calcium binding protein 39 (CAB39, also known as MO25). The protein activates STK11 leading to the phosphorylation of both proteins and excluding STK11 from the nucleus. The protein is necessary for STK11-induced G1 cell cycle arrest. A mutation in this gene has been shown to result in polyhydramnios, megalencephaly, and symptomatic epilepsy (PMSE) syndrome. Multiple transcript variants encoding different isoforms have been found for this gene. Additional transcript variants have been described but their full-length nature is not known. [provided by RefSeq, Sep 2009].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| STE20-related kinase adaptor alpha | MIM:608626 | Ensembl:ENSG00000266173 | HGNC:HGNC:30172 | PA164726342 | 17q23.3 |
GO terms in STRADA
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IBA | GO:0000165 | MAPK cascade |
| BP | IDA | GO:0006468 | protein phosphorylation |
| BP | IDA | GO:0006611 | protein export from nucleus |
| BP | TAS | GO:0007050 | cell cycle arrest |
| BP | IBA | GO:0007346 | regulation of mitotic cell cycle |
| BP | IBA | GO:0023014 | signal transduction by protein phosphorylation |
| BP | IBA | GO:0032147 | activation of protein kinase activity |
| BP | IDA | GO:0032147 | activation of protein kinase activity |
| BP | IBA | GO:0048812 | neuron projection morphogenesis |
| BP | IEA | GO:0071902 | positive regulation of protein serine/threonine kinase activity |
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| MF | IDA | GO:0004672 | protein kinase activity |
| MF | IBA | GO:0004674 | protein serine/threonine kinase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IPI | GO:0019900 | kinase binding |
| MF | IDA | GO:0030295 | protein kinase activator activity |
| MF | IDA | GO:0043539 | protein serine/threonine kinase activator activity |
Gene expression in normal tissue: STRADA
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in STRADA
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP1403 | AMP-activated Protein Kinase (AMPK) Signaling |
| wikipathways | WP3932 | Focal Adhesion-PI3K-Akt-mTOR-signaling pathway |
| pid | lkb1_pathway | LKB1 signaling events |
| kegg | hsa04150 | mTOR signaling pathway - Homo sapiens (human) |
| kegg | hsa04152 | AMPK signaling pathway - Homo sapiens (human) |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-165159 | mTOR signalling |
| reactome | R-HSA-380972 | Energy dependent regulation of mTOR by LKB1-AMPK |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD307 | Manumycin A | 3 |
| iGMDRD84 | Lovastatin acid | 3 |
| iGMDRD345 | Compound 10b [PMID: 11504634] | 3 |
| iGMDRD237 | ABT-751 | 5 |
| iGMDRD351 | GW843682X | 3 |
| iGMDRD341 | Triacsin c | 2 |
| iGMDRD123 | Isoevodiamine | 6 |
| iGMDRD901 | ELCPK | 3 |
| iGMDRD137 | Indisulam | 4 |
| iGMDRD434 | BMS-536924 | 3 |
| iGMDRD705 | Nakiterpiosin | 2 |
| iGMDRD6 | AM-580 | 3 |
| iGMDRD329 | Merck60 | 2 |
| iGMDRD872 | BRD7137 | 4 |
| iGMDRD367 | Ro 28-1675 | 3 |
| iGMDRD286 | Nsc 632839 | 3 |
| iGMDRD300 | Tozasertib | 3 |
| iGMDRD579 | PF750 | 3 |
| iGMDRD1008 | SR-II-138A | 1 |
| iGMDRD433 | Lexibulin | 3 |
| iGMDRD126 | Tipifarnib | 3 |
| iGMDRD781 | Sirolimus | 3 |
| iGMDRD483 | SCH-529074 | 6 |
| iGMDRD193 | Fqi1 | 4 |
| iGMDRD446 | LY 2183240 | 3 |
| iGMDRD634 | SCHEMBL2608041 | 3 |
| iGMDRD679 | Bistramide A | 1 |
| iGMDRD280 | CYTOCHALASIN B | 2 |
| iGMDRD138 | PX 12 | 3 |
| iGMDRD885 | Compound 110 | 3 |
| iGMDRD562 | Navitoclax | 3 |
| iGMDRD577 | BIX01294 | 2 |
| iGMDRD74 | Idarubicin | 3 |
| iGMDRD188 | Piperlongumine | 2 |
| iGMDRD100 | Zebularine | 3 |
| iGMDRD23 | Gossypol | 2 |
| iGMDRD64 | Parbendazole | 6 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in STRADA
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