STRADA


Summary: The protein encoded by this gene contains a STE20-like kinase domain, but lacks several residues that are critical for catalytic activity, so it is termed a 'pseudokinase'. The protein forms a heterotrimeric complex with serine/threonine kinase 11 (STK11, also known as LKB1) and the scaffolding protein calcium binding protein 39 (CAB39, also known as MO25). The protein activates STK11 leading to the phosphorylation of both proteins and excluding STK11 from the nucleus. The protein is necessary for STK11-induced G1 cell cycle arrest. A mutation in this gene has been shown to result in polyhydramnios, megalencephaly, and symptomatic epilepsy (PMSE) syndrome. Multiple transcript variants encoding different isoforms have been found for this gene. Additional transcript variants have been described but their full-length nature is not known. [provided by RefSeq, Sep 2009].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location

GO terms in STRADA


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Term Type
Evidence Type
GO Term ID
GO Des.
BP IBA GO:0000165 MAPK cascade
BP IDA GO:0006468 protein phosphorylation
BP IDA GO:0006611 protein export from nucleus
BP TAS GO:0007050 cell cycle arrest
BP IBA GO:0007346 regulation of mitotic cell cycle
BP IBA GO:0023014 signal transduction by protein phosphorylation
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Gene expression in normal tissue: STRADA

16 tissues mixtureadiposeadrenalbrainbreastcolonheartkidneyliverlunglymph nodeovaryprostateskeletal muscletestesthyroidwhite blood cells

Gene-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 69BOWEtissue: BOWE cancer: BOWEL model num: 0BOWELtissue: BOWEL cancer: undefined model num: 15LUNtissue: LUN cancer: LUNG model num: 0LUNGtissue: LUNG cancer: undefined model num: 9BLOOtissue: BLOO cancer: BLOOD model num: 0BLOODtissue: BLOOD cancer: undefined model num: 21

Gene-drug pathway distribution

Pathways in STRADA


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Database
Pathway ID
Pathway Des.
wikipathways WP1403 AMP-activated Protein Kinase (AMPK) Signaling
wikipathways WP3932 Focal Adhesion-PI3K-Akt-mTOR-signaling pathway
pid lkb1_pathway LKB1 signaling events
kegg hsa04150 mTOR signaling pathway - Homo sapiens (human)
kegg hsa04152 AMPK signaling pathway - Homo sapiens (human)
reactome R-HSA-162582 Signal Transduction
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD307 Manumycin A 3
iGMDRD84 Lovastatin acid 3
iGMDRD345 Compound 10b [PMID: 11504634] 3
iGMDRD237 ABT-751 5
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in STRADA

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
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