PCM1
Summary: The protein encoded by this gene is a component of centriolar satellites, which are electron dense granules scattered around centrosomes. Inhibition studies show that this protein is essential for the correct localization of several centrosomal proteins, and for anchoring microtubules to the centrosome. Chromosomal aberrations involving this gene are associated with papillary thyroid carcinomas and a variety of hematological malignancies, including atypical chronic myeloid leukemia and T-cell lymphoma. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| pericentriolar material 1 | MIM:600299 | Ensembl:ENSG00000078674 | HGNC:HGNC:8727 | PA33073 | 8p22 |
Gene Categories:
TUMOR SUPPRESSORGO terms in PCM1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IPI | GO:0005515 | protein binding |
| MF | ISS | GO:0042802 | identical protein binding |
| CC | ISS | GO:0000242 | pericentriolar material |
| CC | ISS | GO:0005737 | cytoplasm |
| CC | IBA | GO:0005813 | centrosome |
| CC | IDA | GO:0005813 | centrosome |
| CC | IDA | GO:0005813 | centrosome |
| CC | ISS | GO:0005813 | centrosome |
| CC | IEA | GO:0005814 | centriole |
| CC | IDA | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| CC | HDA | GO:0016020 | membrane |
| CC | IDA | GO:0031965 | nuclear membrane |
| CC | IDA | GO:0032991 | protein-containing complex |
| CC | IDA | GO:0034451 | centriolar satellite |
| CC | IDA | GO:0035869 | ciliary transition zone |
| CC | IEA | GO:0036064 | ciliary basal body |
| CC | IEA | GO:0045177 | apical part of cell |
| CC | IDA | GO:0097730 | non-motile cilium |
| BP | TAS | GO:0000086 | G2/M transition of mitotic cell cycle |
| BP | IEA | GO:0001764 | neuron migration |
| BP | IMP | GO:0007098 | centrosome cycle |
| BP | TAS | GO:0010389 | regulation of G2/M transition of mitotic cell cycle |
| BP | ISS | GO:0022027 | interkinetic nuclear migration |
| BP | IMP | GO:0031122 | cytoplasmic microtubule organization |
| BP | ISS | GO:0034453 | microtubule anchoring |
| BP | IBA | GO:0034454 | microtubule anchoring at centrosome |
| BP | IEA | GO:0035176 | social behavior |
| BP | IMP | GO:0035735 | intraciliary transport involved in cilium assembly |
| BP | ISS | GO:0050768 | negative regulation of neurogenesis |
| BP | IMP | GO:0060271 | cilium assembly |
| BP | IBA | GO:0071539 | protein localization to centrosome |
| BP | IMP | GO:0071539 | protein localization to centrosome |
| BP | ISS | GO:0071539 | protein localization to centrosome |
| BP | IMP | GO:0090316 | positive regulation of intracellular protein transport |
| BP | IEA | GO:0097150 | neuronal stem cell population maintenance |
| BP | TAS | GO:0097711 | ciliary basal body-plasma membrane docking |
| BP | IMP | GO:1905515 | non-motile cilium assembly |
Gene expression in normal tissue: PCM1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PCM1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP3998 | Prader-Willi and Angelman Syndrome |
| reactome | R-HSA-1640170 | Cell Cycle |
| reactome | R-HSA-1852241 | Organelle biogenesis and maintenance |
| reactome | R-HSA-2565942 | Regulation of PLK1 Activity at G2/M Transition |
| reactome | R-HSA-380259 | Loss of Nlp from mitotic centrosomes |
| reactome | R-HSA-380270 | Recruitment of mitotic centrosome proteins and complexes |
| reactome | R-HSA-380284 | Loss of proteins required for interphase microtubule organization from the centrosome |
| reactome | R-HSA-380287 | Centrosome maturation |
| reactome | R-HSA-380320 | Recruitment of NuMA to mitotic centrosomes |
| reactome | R-HSA-453274 | Mitotic G2-G2/M phases |
| reactome | R-HSA-5617833 | Cilium Assembly |
| reactome | R-HSA-5620912 | Anchoring of the basal body to the plasma membrane |
| reactome | R-HSA-68877 | Mitotic Prometaphase |
| reactome | R-HSA-68886 | M Phase |
| reactome | R-HSA-69275 | G2/M Transition |
| reactome | R-HSA-69278 | Cell Cycle, Mitotic |
| reactome | R-HSA-8854518 | AURKA Activation by TPX2 |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD85 | Ursolic acid | 1 |
| iGMDRD351 | GW843682X | 3 |
| iGMDRD193 | Fqi1 | 3 |
| iGMDRD280 | CYTOCHALASIN B | 3 |
| iGMDRD123 | Isoevodiamine | 4 |
| iGMDRD126 | Tipifarnib | 4 |
| iGMDRD387 | CHIR-99021 | 2 |
| iGMDRD420 | Leucascandrolide A | 3 |
| iGMDRD345 | Compound 10b [PMID: 11504634] | 3 |
| iGMDRD494 | Neopeltolide | 3 |
| iGMDRD100 | Zebularine | 1 |
| iGMDRD414 | MST-312 | 6 |
| iGMDRD188 | Piperlongumine | 3 |
| iGMDRD399 | Selumetinib | 3 |
| iGMDRD506 | Fedratinib | 3 |
| iGMDRD329 | Merck60 | 4 |
| iGMDRD780 | PP-30 | 3 |
| iGMDRD398 | Sepantronium | 2 |
| iGMDRD505 | Pevonedistat | 3 |
| iGMDRD64 | Parbendazole | 3 |
| iGMDRD158 | NSC141540 | 3 |
| iGMDRD137 | Indisulam | 3 |
| iGMDRD613 | CHEMBL258148 | 3 |
| iGMDRD705 | Nakiterpiosin | 3 |
| iGMDRD434 | BMS-536924 | 1 |
| iGMDRD782 | DC-45-A2 | 3 |
| iGMDRD171 | Pemetrexed | 3 |
| iGMDRD885 | Compound 110 | 2 |
| iGMDRD187 | BRD9876 | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PCM1
CLASSFICATION
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