GDNF
Summary: This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. The recombinant form of this protein, a highly conserved neurotrophic factor, was shown to promote the survival and differentiation of dopaminergic neurons in culture, and was able to prevent apoptosis of motor neurons induced by axotomy. This protein is a ligand for the product of the RET (rearranged during transfection) protooncogene. Mutations in this gene may be associated with Hirschsprung disease and Tourette syndrome. This gene encodes multiple protein isoforms that may undergo similar proteolytic processing. [provided by RefSeq, Aug 2016].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| glial cell derived neurotrophic factor | MIM:600837 | Ensembl:ENSG00000168621 | HGNC:HGNC:4232 | PA28644 | 5p13.2 |
GO terms in GDNF
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | TAS | GO:0000165 | MAPK cascade |
| BP | ISS | GO:0001656 | metanephros development |
| BP | ISS | GO:0001658 | branching involved in ureteric bud morphogenesis |
| BP | IDA | GO:0001755 | neural crest cell migration |
| BP | IEA | GO:0001759 | organ induction |
| BP | IEA | GO:0001941 | postsynaptic membrane organization |
| BP | IEA | GO:0003337 | mesenchymal to epithelial transition involved in metanephros morphogenesis |
| BP | TAS | GO:0007165 | signal transduction |
| BP | TAS | GO:0007399 | nervous system development |
| BP | TAS | GO:0007411 | axon guidance |
| BP | IDA | GO:0008284 | positive regulation of cell proliferation |
| BP | TAS | GO:0008344 | adult locomotory behavior |
| BP | IGI | GO:0010468 | regulation of gene expression |
| BP | IEA | GO:0010469 | regulation of signaling receptor activity |
| BP | ISS | GO:0021516 | dorsal spinal cord development |
| BP | ISS | GO:0021784 | postganglionic parasympathetic fiber development |
| BP | ISS | GO:0030432 | peristalsis |
| BP | IDA | GO:0031175 | neuron projection development |
| BP | TAS | GO:0031175 | neuron projection development |
| BP | IDA | GO:0032770 | positive regulation of monooxygenase activity |
| BP | TAS | GO:0033603 | positive regulation of dopamine secretion |
| BP | TAS | GO:0043066 | negative regulation of apoptotic process |
| BP | IDA | GO:0043524 | negative regulation of neuron apoptotic process |
| BP | IGI | GO:0045597 | positive regulation of cell differentiation |
| BP | IDA | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IDA | GO:0048255 | mRNA stabilization |
| BP | ISS | GO:0048484 | enteric nervous system development |
| BP | ISS | GO:0048485 | sympathetic nervous system development |
| BP | ISS | GO:0048568 | embryonic organ development |
| BP | IDA | GO:0051584 | regulation of dopamine uptake involved in synaptic transmission |
| BP | IEA | GO:0060676 | ureteric bud formation |
| BP | ISS | GO:0060688 | regulation of morphogenesis of a branching structure |
| BP | ISS | GO:0071679 | commissural neuron axon guidance |
| BP | IDA | GO:0072107 | positive regulation of ureteric bud formation |
| BP | IEA | GO:0072108 | positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis |
| BP | IDA | GO:0090190 | positive regulation of branching involved in ureteric bud morphogenesis |
| BP | TAS | GO:2000736 | regulation of stem cell differentiation |
| BP | IDA | GO:2001240 | negative regulation of extrinsic apoptotic signaling pathway in absence of ligand |
| BP | ISS | GO:2001260 | regulation of semaphorin-plexin signaling pathway |
| CC | IDA | GO:0005576 | extracellular region |
| CC | TAS | GO:0005576 | extracellular region |
| CC | IEA | GO:0005622 | intracellular |
| MF | TAS | GO:0005088 | Ras guanyl-nucleotide exchange factor activity |
| MF | TAS | GO:0005102 | signaling receptor binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0008083 | growth factor activity |
| MF | IDA | GO:0042803 | protein homodimerization activity |
| MF | TAS | GO:1902379 | chemoattractant activity involved in axon guidance |
Gene expression in normal tissue: GDNF
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in GDNF
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-375165 | NCAM signaling for neurite out-growth |
| reactome | R-HSA-419037 | NCAM1 interactions |
| reactome | R-HSA-422475 | Axon guidance |
| reactome | R-HSA-422475 | Axon guidance |
| reactome | R-HSA-5673001 | RAF/MAP kinase cascade |
| reactome | R-HSA-5683057 | MAPK family signaling cascades |
| reactome | R-HSA-5684996 | MAPK1/MAPK3 signaling |
| reactome | R-HSA-8853659 | RET signaling |
| wikipathways | WP2328 | Allograft Rejection |
| wikipathways | WP2431 | Spinal Cord Injury |
| pid | ajdiss_2pathway | Posttranslational regulation of adherens junction stability and dissassembly |
| pid | ret_pathway | Signaling events regulated by Ret tyrosine kinase |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD280 | CYTOCHALASIN B | 6 |
| iGMDRD679 | Bistramide A | 6 |
| iGMDRD634 | SCHEMBL2608041 | 5 |
| iGMDRD446 | LY 2183240 | 1 |
| iGMDRD61 | Kinetin riboside | 3 |
| iGMDRD718 | Pyrvinium pamoate | 1 |
| iGMDRD483 | SCH-529074 | 3 |
| iGMDRD126 | Tipifarnib | 3 |
| iGMDRD772 | BRD4770 | 3 |
| iGMDRD579 | PF750 | 2 |
| iGMDRD387 | CHIR-99021 | 3 |
| iGMDRD64 | Parbendazole | 3 |
| iGMDRD524 | ISX-9 | 6 |
| iGMDRD23 | Gossypol | 6 |
| iGMDRD100 | Zebularine | 3 |
| iGMDRD506 | Fedratinib | 4 |
| iGMDRD171 | Pemetrexed | 3 |
| iGMDRD870 | BRD63610 | 3 |
| iGMDRD294 | Batimastat | 2 |
| iGMDRD123 | Isoevodiamine | 6 |
| iGMDRD154 | NSC23766 | 6 |
| iGMDRD237 | ABT-751 | 1 |
| iGMDRD424 | Tamatinib | 1 |
| iGMDRD345 | Compound 10b [PMID: 11504634] | 4 |
| iGMDRD150 | RITA | 4 |
| iGMDRD607 | Ubistatin B | 3 |
| iGMDRD322 | FK 866 | 1 |
| iGMDRD871 | BRD6368 | 3 |
| iGMDRD269 | Purmorphamine | 3 |
| iGMDRD329 | Merck60 | 3 |
| iGMDRD137 | Indisulam | 6 |
| iGMDRD121 | GMX1778 | 6 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in GDNF
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