GDNF


Summary: This gene encodes a secreted ligand of the TGF-beta (transforming growth factor-beta) superfamily of proteins. Ligands of this family bind various TGF-beta receptors leading to recruitment and activation of SMAD family transcription factors that regulate gene expression. The encoded preproprotein is proteolytically processed to generate each subunit of the disulfide-linked homodimer. The recombinant form of this protein, a highly conserved neurotrophic factor, was shown to promote the survival and differentiation of dopaminergic neurons in culture, and was able to prevent apoptosis of motor neurons induced by axotomy. This protein is a ligand for the product of the RET (rearranged during transfection) protooncogene. Mutations in this gene may be associated with Hirschsprung disease and Tourette syndrome. This gene encodes multiple protein isoforms that may undergo similar proteolytic processing. [provided by RefSeq, Aug 2016].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
glial cell derived neurotrophic factorMIM:600837Ensembl:ENSG00000168621HGNC:HGNC:4232PA286445p13.2

GO terms in GDNF


Term TypeEvidence TypeGO Term IDGO Des.
BPTASGO:0000165MAPK cascade
BPISSGO:0001656metanephros development
BPISSGO:0001658branching involved in ureteric bud morphogenesis
BPIDAGO:0001755neural crest cell migration
BPIEAGO:0001759organ induction
BPIEAGO:0001941postsynaptic membrane organization
BPIEAGO:0003337mesenchymal to epithelial transition involved in metanephros morphogenesis
BPTASGO:0007165signal transduction
BPTASGO:0007399nervous system development
BPTASGO:0007411axon guidance
BPIDAGO:0008284positive regulation of cell proliferation
BPTASGO:0008344adult locomotory behavior
BPIGIGO:0010468regulation of gene expression
BPIEAGO:0010469regulation of signaling receptor activity
BPISSGO:0021516dorsal spinal cord development
BPISSGO:0021784postganglionic parasympathetic fiber development
BPISSGO:0030432peristalsis
BPIDAGO:0031175neuron projection development
BPTASGO:0031175neuron projection development
BPIDAGO:0032770positive regulation of monooxygenase activity
BPTASGO:0033603positive regulation of dopamine secretion
BPTASGO:0043066negative regulation of apoptotic process
BPIDAGO:0043524negative regulation of neuron apoptotic process
BPIGIGO:0045597positive regulation of cell differentiation
BPIDAGO:0045944positive regulation of transcription by RNA polymerase II
BPIDAGO:0048255mRNA stabilization
BPISSGO:0048484enteric nervous system development
BPISSGO:0048485sympathetic nervous system development
BPISSGO:0048568embryonic organ development
BPIDAGO:0051584regulation of dopamine uptake involved in synaptic transmission
BPIEAGO:0060676ureteric bud formation
BPISSGO:0060688regulation of morphogenesis of a branching structure
BPISSGO:0071679commissural neuron axon guidance
BPIDAGO:0072107positive regulation of ureteric bud formation
BPIEAGO:0072108positive regulation of mesenchymal to epithelial transition involved in metanephros morphogenesis
BPIDAGO:0090190positive regulation of branching involved in ureteric bud morphogenesis
BPTASGO:2000736regulation of stem cell differentiation
BPIDAGO:2001240negative regulation of extrinsic apoptotic signaling pathway in absence of ligand
BPISSGO:2001260regulation of semaphorin-plexin signaling pathway
CCIDAGO:0005576extracellular region
CCTASGO:0005576extracellular region
CCIEAGO:0005622intracellular
MFTASGO:0005088Ras guanyl-nucleotide exchange factor activity
MFTASGO:0005102signaling receptor binding
MFIPIGO:0005515protein binding
MFIEAGO:0008083growth factor activity
MFIDAGO:0042803protein homodimerization activity
MFTASGO:1902379chemoattractant activity involved in axon guidance

Gene expression in normal tissue: GDNF

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in GDNF


DatabasePathway IDPathway Des.
reactomeR-HSA-1266738Developmental Biology
reactomeR-HSA-1266738Developmental Biology
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-375165NCAM signaling for neurite out-growth
reactomeR-HSA-419037NCAM1 interactions
reactomeR-HSA-422475Axon guidance
reactomeR-HSA-422475Axon guidance
reactomeR-HSA-5673001RAF/MAP kinase cascade
reactomeR-HSA-5683057MAPK family signaling cascades
reactomeR-HSA-5684996MAPK1/MAPK3 signaling
reactomeR-HSA-8853659RET signaling
wikipathwaysWP2328Allograft Rejection
wikipathwaysWP2431Spinal Cord Injury
pidajdiss_2pathwayPosttranslational regulation of adherens junction stability and dissassembly
pidret_pathwaySignaling events regulated by Ret tyrosine kinase

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD280CYTOCHALASIN B6
iGMDRD679Bistramide A6
iGMDRD634SCHEMBL26080415
iGMDRD446LY 21832401
iGMDRD61Kinetin riboside3
iGMDRD718Pyrvinium pamoate1
iGMDRD483SCH-5290743
iGMDRD126Tipifarnib3
iGMDRD772BRD47703
iGMDRD579PF7502
iGMDRD387CHIR-990213
iGMDRD64Parbendazole3
iGMDRD524ISX-96
iGMDRD23Gossypol6
iGMDRD100Zebularine3
iGMDRD506Fedratinib4
iGMDRD171Pemetrexed3
iGMDRD870BRD636103
iGMDRD294Batimastat2
iGMDRD123Isoevodiamine6
iGMDRD154NSC237666
iGMDRD237ABT-7511
iGMDRD424Tamatinib1
iGMDRD345Compound 10b [PMID: 11504634]4
iGMDRD150RITA4
iGMDRD607Ubistatin B3
iGMDRD322FK 8661
iGMDRD871BRD63683
iGMDRD269Purmorphamine3
iGMDRD329Merck603
iGMDRD137Indisulam6
iGMDRD121GMX17786

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in GDNF

​​​​