PBX1
Summary: This gene encodes a nuclear protein that belongs to the PBX homeobox family of transcriptional factors. Studies in mice suggest that this gene may be involved in the regulation of osteogenesis and required for skeletal patterning and programming. A chromosomal translocation, t(1;19) involving this gene and TCF3/E2A gene, is associated with pre-B-cell acute lymphoblastic leukemia. The resulting fusion protein, in which the DNA binding domain of E2A is replaced by the DNA binding domain of this protein, transforms cells by constitutively activating transcription of genes regulated by the PBX protein family. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2017].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| PBX homeobox 1 | MIM:176310 | Ensembl:ENSG00000185630 | HGNC:HGNC:8632 | PA32970 | 1q23.3 |
GO terms in PBX1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0090575 | RNA polymerase II transcription factor complex |
| BP | IEA | GO:0001658 | branching involved in ureteric bud morphogenesis |
| BP | IEA | GO:0006366 | transcription by RNA polymerase II |
| BP | IEA | GO:0006694 | steroid biosynthetic process |
| BP | TAS | GO:0007221 | positive regulation of transcription of Notch receptor target |
| BP | IEA | GO:0007548 | sex differentiation |
| BP | IEA | GO:0008284 | positive regulation of cell proliferation |
| BP | IEA | GO:0009952 | anterior/posterior pattern specification |
| BP | IEA | GO:0009954 | proximal/distal pattern formation |
| BP | IEA | GO:0010971 | positive regulation of G2/M transition of mitotic cell cycle |
| BP | IEA | GO:0030278 | regulation of ossification |
| BP | IEA | GO:0030325 | adrenal gland development |
| BP | IEA | GO:0030326 | embryonic limb morphogenesis |
| BP | TAS | GO:0035019 | somatic stem cell population maintenance |
| BP | IEA | GO:0035162 | embryonic hemopoiesis |
| BP | IEA | GO:0045665 | negative regulation of neuron differentiation |
| BP | IEA | GO:0048536 | spleen development |
| BP | IEA | GO:0048538 | thymus development |
| BP | IEA | GO:0048706 | embryonic skeletal system development |
| MF | IDA | GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding |
| MF | IEA | GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding |
| MF | ISA | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | ISM | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | NAS | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | IEA | GO:0001077 | transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding |
| MF | IDA | GO:0003677 | DNA binding |
| MF | NAS | GO:0003700 | DNA-binding transcription factor activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0046982 | protein heterodimerization activity |
Gene expression in normal tissue: PBX1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PBX1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP2857 | Mesodermal Commitment Pathway |
| wikipathways | WP3527 | Preimplantation Embryo |
| wikipathways | WP706 | Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways |
| pid | reg_gr_pathway | Glucocorticoid receptor regulatory network |
| kegg | hsa04927 | Cortisol synthesis and secretion - Homo sapiens (human) |
| kegg | hsa04934 | Cushing,s syndrome - Homo sapiens (human) |
| kegg | hsa05202 | Transcriptional misregulation in cancer - Homo sapiens (human) |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-157118 | Signaling by NOTCH |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-452723 | Transcriptional regulation of pluripotent stem cells |
| reactome | R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogenesis |
| reactome | R-HSA-5619507 | Activation of HOX genes during differentiation |
| reactome | R-HSA-9012852 | Signaling by NOTCH3 |
| reactome | R-HSA-9013508 | NOTCH3 Intracellular Domain Regulates Transcription |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD77 | Itraconazole | 3 |
| iGMDRD705 | Nakiterpiosin | 3 |
| iGMDRD289 | Parthenolide | 1 |
| iGMDRD105 | Triptolide | 2 |
| iGMDRD5 | Tyrphostin AG 1478 | 1 |
| iGMDRD137 | Indisulam | 4 |
| iGMDRD158 | NSC141540 | 2 |
| iGMDRD103 | SN-38 | 1 |
| iGMDRD82 | Quiflapon | 3 |
| iGMDRD505 | Pevonedistat | 3 |
| iGMDRD329 | Merck60 | 3 |
| iGMDRD872 | BRD7137 | 3 |
| iGMDRD367 | Ro 28-1675 | 3 |
| iGMDRD701 | NVP-AUY922 | 1 |
| iGMDRD345 | Compound 10b [PMID: 11504634] | 2 |
| iGMDRD150 | RITA | 3 |
| iGMDRD148 | Pifithrin-mu | 4 |
| iGMDRD512 | nutlin 3 | 3 |
| iGMDRD307 | Manumycin A | 6 |
| iGMDRD84 | Lovastatin acid | 1 |
| iGMDRD945 | ML214 | 4 |
| iGMDRD123 | Isoevodiamine | 1 |
| iGMDRD211 | (1S,3R)-RSL3 | 2 |
| iGMDRD341 | Triacsin c | 6 |
| iGMDRD870 | BRD63610 | 6 |
| iGMDRD885 | Compound 110 | 2 |
| iGMDRD138 | PX 12 | 1 |
| iGMDRD270 | Ciclosporin | 2 |
| iGMDRD524 | ISX-9 | 1 |
| iGMDRD268 | Cerulenin | 2 |
| iGMDRD23 | Gossypol | 3 |
| iGMDRD888 | Compound 44 | 3 |
| iGMDRD577 | BIX01294 | 1 |
| iGMDRD506 | Fedratinib | 5 |
| iGMDRD74 | Idarubicin | 1 |
| iGMDRD887 | Compound 23 citrate | 2 |
| iGMDRD188 | Piperlongumine | 2 |
| iGMDRD100 | Zebularine | 3 |
| iGMDRD427 | ABT737 | 3 |
| iGMDRD670 | ML 210 | 2 |
| iGMDRD889 | Compound 7d-cis | 4 |
| iGMDRD599 | Salermide | 1 |
| iGMDRD210 | AC55649 | 1 |
| iGMDRD554 | CHEMBL1434137 | 2 |
| iGMDRD634 | SCHEMBL2608041 | 2 |
| iGMDRD280 | CYTOCHALASIN B | 8 |
| iGMDRD297 | Austocystin D | 1 |
| iGMDRD61 | Kinetin riboside | 1 |
| iGMDRD316 | N9-Isopropyl-olomoucine | 1 |
| iGMDRD201 | SKI II | 5 |
| iGMDRD446 | LY 2183240 | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PBX1
CLASSFICATION
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