TLR9
Summary: The protein encoded by this gene is a member of the Toll-like receptor (TLR) family, which plays a fundamental role in pathogen recognition and activation of innate immunity. TLRs are highly conserved from Drosophila to humans and share structural and functional similarities. They recognize pathogen-associated molecular patterns (PAMPs) that are expressed on infectious agents, and mediate the production of cytokines necessary for the development of effective immunity. Studies in mice and human indicate that this receptor mediates cellular response to unmethylated CpG dinucleotides in bacterial DNA to mount an innate immune response. [provided by RefSeq, Aug 2017].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| toll like receptor 9 | MIM:605474 | Ensembl:ENSG00000239732 | HGNC:HGNC:15633 | PA38010 | 3p21.2 |
GO terms in TLR9
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IEA | GO:0004888 | transmembrane signaling receptor activity |
| MF | IPI | GO:0005149 | interleukin-1 receptor binding |
| MF | IBA | GO:0008329 | signaling pattern recognition receptor activity |
| MF | TAS | GO:0016303 | 1-phosphatidylinositol-3-kinase activity |
| MF | IMP | GO:0035197 | siRNA binding |
| MF | ISS | GO:0042803 | protein homodimerization activity |
| MF | ISS | GO:0045322 | unmethylated CpG binding |
| CC | TAS | GO:0000139 | Golgi membrane |
| CC | NAS | GO:0005576 | extracellular region |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | ISS | GO:0005764 | lysosome |
| CC | ISS | GO:0005768 | endosome |
| CC | ISS | GO:0005783 | endoplasmic reticulum |
| CC | TAS | GO:0005789 | endoplasmic reticulum membrane |
| CC | IBA | GO:0005886 | plasma membrane |
| CC | IDA | GO:0005886 | plasma membrane |
| CC | TAS | GO:0010008 | endosome membrane |
| CC | IEA | GO:0016021 | integral component of membrane |
| CC | IDA | GO:0016323 | basolateral plasma membrane |
| CC | IDA | GO:0016324 | apical plasma membrane |
| CC | ISS | GO:0032009 | early phagosome |
| CC | TAS | GO:0036020 | endolysosome membrane |
| BP | IBA | GO:0002224 | toll-like receptor signaling pathway |
| BP | TAS | GO:0002224 | toll-like receptor signaling pathway |
| BP | IBA | GO:0002237 | response to molecule of bacterial origin |
| BP | TAS | GO:0002237 | response to molecule of bacterial origin |
| BP | IDA | GO:0002639 | positive regulation of immunoglobulin production |
| BP | IEA | GO:0002755 | MyD88-dependent toll-like receptor signaling pathway |
| BP | IEA | GO:0006954 | inflammatory response |
| BP | IBA | GO:0006955 | immune response |
| BP | IBA | GO:0007249 | I-kappaB kinase/NF-kappaB signaling |
| BP | IDA | GO:0007252 | I-kappaB phosphorylation |
| BP | IDA | GO:0010628 | positive regulation of gene expression |
| BP | ISS | GO:0030277 | maintenance of gastrointestinal epithelium |
| BP | IDA | GO:0030890 | positive regulation of B cell proliferation |
| BP | IDA | GO:0032088 | negative regulation of NF-kappaB transcription factor activity |
| BP | IBA | GO:0032640 | tumor necrosis factor production |
| BP | IDA | GO:0032640 | tumor necrosis factor production |
| BP | ISS | GO:0032715 | negative regulation of interleukin-6 production |
| BP | IDA | GO:0032717 | negative regulation of interleukin-8 production |
| BP | IDA | GO:0032722 | positive regulation of chemokine production |
| BP | IDA | GO:0032725 | positive regulation of granulocyte macrophage colony-stimulating factor production |
| BP | ISS | GO:0032728 | positive regulation of interferon-beta production |
| BP | ISS | GO:0032733 | positive regulation of interleukin-10 production |
| BP | ISS | GO:0032735 | positive regulation of interleukin-12 production |
| BP | ISS | GO:0032741 | positive regulation of interleukin-18 production |
| BP | IBA | GO:0032755 | positive regulation of interleukin-6 production |
| BP | IDA | GO:0032755 | positive regulation of interleukin-6 production |
| BP | IDA | GO:0032757 | positive regulation of interleukin-8 production |
| BP | ISS | GO:0032760 | positive regulation of tumor necrosis factor production |
| BP | IDA | GO:0034122 | negative regulation of toll-like receptor signaling pathway |
| BP | IDA | GO:0034123 | positive regulation of toll-like receptor signaling pathway |
| BP | TAS | GO:0034162 | toll-like receptor 9 signaling pathway |
| BP | IDA | GO:0034163 | regulation of toll-like receptor 9 signaling pathway |
| BP | IEA | GO:0036092 | phosphatidylinositol-3-phosphate biosynthetic process |
| BP | NAS | GO:0042742 | defense response to bacterium |
| BP | IDA | GO:0043123 | positive regulation of I-kappaB kinase/NF-kappaB signaling |
| BP | IDA | GO:0043410 | positive regulation of MAPK cascade |
| BP | IDA | GO:0043507 | positive regulation of JUN kinase activity |
| BP | IBA | GO:0045078 | positive regulation of interferon-gamma biosynthetic process |
| BP | IDA | GO:0045078 | positive regulation of interferon-gamma biosynthetic process |
| BP | TAS | GO:0045087 | innate immune response |
| BP | IDA | GO:0045356 | positive regulation of interferon-alpha biosynthetic process |
| BP | IBA | GO:0045359 | positive regulation of interferon-beta biosynthetic process |
| BP | IDA | GO:0045359 | positive regulation of interferon-beta biosynthetic process |
| BP | IBA | GO:0045416 | positive regulation of interleukin-8 biosynthetic process |
| BP | IDA | GO:0045577 | regulation of B cell differentiation |
| BP | ISS | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IC | GO:0046330 | positive regulation of JNK cascade |
| BP | IEA | GO:0050707 | regulation of cytokine secretion |
| BP | IC | GO:0050729 | positive regulation of inflammatory response |
| BP | IMP | GO:0050829 | defense response to Gram-negative bacterium |
| BP | IDA | GO:0050871 | positive regulation of B cell activation |
| BP | IBA | GO:0051092 | positive regulation of NF-kappaB transcription factor activity |
| BP | IDA | GO:0051092 | positive regulation of NF-kappaB transcription factor activity |
| BP | IBA | GO:0051607 | defense response to virus |
| BP | ISS | GO:0051770 | positive regulation of nitric-oxide synthase biosynthetic process |
| BP | IDA | GO:1901224 | positive regulation of NIK/NF-kappaB signaling |
| BP | IDA | GO:1901895 | negative regulation of calcium-transporting ATPase activity |
Gene expression in normal tissue: TLR9
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in TLR9
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP1449 | Regulation of toll-like receptor signaling pathway |
| wikipathways | WP3858 | Toll-like Receptor Signaling |
| wikipathways | WP3877 | Simplified Depiction of MYD88 Distinct Input-Output Pathway |
| wikipathways | WP75 | Toll-like Receptor Signaling Pathway |
| kegg | hsa04620 | Toll-like receptor signaling pathway - Homo sapiens (human) |
| kegg | hsa05142 | Chagas disease (American trypanosomiasis) - Homo sapiens (human) |
| kegg | hsa05143 | African trypanosomiasis - Homo sapiens (human) |
| kegg | hsa05144 | Malaria - Homo sapiens (human) |
| kegg | hsa05152 | Tuberculosis - Homo sapiens (human) |
| kegg | hsa05162 | Measles - Homo sapiens (human) |
| kegg | hsa05168 | Herpes simplex infection - Homo sapiens (human) |
| biocarta | tollpathway | toll-like receptor pathway |
| reactome | R-HSA-109704 | PI3K Cascade |
| reactome | R-HSA-112399 | IRS-mediated signalling |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-1679131 | Trafficking and processing of endosomal TLR |
| reactome | R-HSA-168138 | Toll Like Receptor 9 (TLR9) Cascade |
| reactome | R-HSA-168181 | Toll Like Receptor 7/8 (TLR7/8) Cascade |
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-168898 | Toll-Like Receptors Cascades |
| reactome | R-HSA-2404192 | Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R) |
| reactome | R-HSA-2428924 | IGF1R signaling cascade |
| reactome | R-HSA-2428928 | IRS-related events triggered by IGF1R |
| reactome | R-HSA-74751 | Insulin receptor signalling cascade |
| reactome | R-HSA-74752 | Signaling by Insulin receptor |
| reactome | R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases |
| reactome | R-HSA-975110 | TRAF6 mediated IRF7 activation in TLR7/8 or 9 signaling |
| reactome | R-HSA-975138 | TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation |
| reactome | R-HSA-975155 | MyD88 dependent cascade initiated on endosome |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD171 | Pemetrexed | 3 |
| iGMDRD670 | ML 210 | 3 |
| iGMDRD434 | BMS-536924 | 3 |
| iGMDRD345 | Compound 10b [PMID: 11504634] | 3 |
| iGMDRD483 | SCH-529074 | 3 |
| iGMDRD137 | Indisulam | 3 |
| iGMDRD121 | GMX1778 | 3 |
| iGMDRD512 | nutlin 3 | 3 |
| iGMDRD280 | CYTOCHALASIN B | 3 |
| iGMDRD64 | Parbendazole | 3 |
| iGMDRD353 | PD0325901 | 1 |
| iGMDRD446 | LY 2183240 | 4 |
| iGMDRD286 | Nsc 632839 | 3 |
| iGMDRD71 | Sparfosic acid | 3 |
| iGMDRD506 | Fedratinib | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in TLR9
CLASSFICATION
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