PHIP
Summary: This gene encodes a protein that binds to the insulin receptor substrate 1 protein and regulates glucose transporter translocation in skeletal muscle cells. The encoded protein may also regulate growth and survival of pancreatic beta cells. Elevated copy number of this gene may be associated with melanoma severity and the encoded protein may promote melanoma metastasis in human patients. [provided by RefSeq, Oct 2016].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| pleckstrin homology domain interacting protein | MIM:612870 | Ensembl:ENSG00000146247 | HGNC:HGNC:15673 | PA33265 | 6q14.1 |
Gene Categories:
TUMOR SUPPRESSORGO terms in PHIP
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IBA | GO:0005634 | nucleus |
| CC | ISS | GO:0005634 | nucleus |
| BP | ISS | GO:0001932 | regulation of protein phosphorylation |
| BP | IBA | GO:0006357 | regulation of transcription by RNA polymerase II |
| BP | IBA | GO:0007010 | cytoskeleton organization |
| BP | IMP | GO:0007010 | cytoskeleton organization |
| BP | ISS | GO:0008284 | positive regulation of cell proliferation |
| BP | NAS | GO:0008286 | insulin receptor signaling pathway |
| BP | IBA | GO:0008360 | regulation of cell shape |
| BP | IMP | GO:0022604 | regulation of cell morphogenesis |
| BP | ISS | GO:0043066 | negative regulation of apoptotic process |
| BP | ISS | GO:0043568 | positive regulation of insulin-like growth factor receptor signaling pathway |
| BP | ISS | GO:0045840 | positive regulation of mitotic nuclear division |
| BP | ISS | GO:0045893 | positive regulation of transcription, DNA-templated |
| BP | IDA | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IDA | GO:2001237 | negative regulation of extrinsic apoptotic signaling pathway |
| MF | NAS | GO:0005158 | insulin receptor binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IDA | GO:0070577 | lysine-acetylated histone binding |
Gene expression in normal tissue: PHIP
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PHIP
| Database | Pathway ID | Pathway Des. |
|---|
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD701 | NVP-AUY922 | 3 |
| iGMDRD483 | SCH-529074 | 4 |
| iGMDRD345 | Compound 10b [PMID: 11504634] | 6 |
| iGMDRD670 | ML 210 | 3 |
| iGMDRD193 | Fqi1 | 1 |
| iGMDRD237 | ABT-751 | 2 |
| iGMDRD351 | GW843682X | 3 |
| iGMDRD314 | Tanespimycin | 3 |
| iGMDRD446 | LY 2183240 | 1 |
| iGMDRD123 | Isoevodiamine | 7 |
| iGMDRD280 | CYTOCHALASIN B | 3 |
| iGMDRD466 | Chaetocin | 3 |
| iGMDRD5 | Tyrphostin AG 1478 | 3 |
| iGMDRD137 | Indisulam | 1 |
| iGMDRD103 | SN-38 | 3 |
| iGMDRD77 | Itraconazole | 3 |
| iGMDRD329 | Merck60 | 3 |
| iGMDRD872 | BRD7137 | 3 |
| iGMDRD356 | PNU-74654 | 3 |
| iGMDRD64 | Parbendazole | 3 |
| iGMDRD60 | Quinoclamine | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PHIP
CLASSFICATION
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