PHIP
Summary: This gene encodes a protein that binds to the insulin receptor substrate 1 protein and regulates glucose transporter translocation in skeletal muscle cells. The encoded protein may also regulate growth and survival of pancreatic beta cells. Elevated copy number of this gene may be associated with melanoma severity and the encoded protein may promote melanoma metastasis in human patients. [provided by RefSeq, Oct 2016].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:612870 Ensembl IDEnsembl:ENSG00000146247 HGNC IDHGNC:HGNC:15673 PHARMGKB IDPA33265 Map Location6q14.1 | |||||
Gene Categories:
TUMOR SUPPRESSORGO terms in PHIP
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Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IBA | GO:0005634 | nucleus |
| CC | ISS | GO:0005634 | nucleus |
| BP | ISS | GO:0001932 | regulation of protein phosphorylation |
| BP | IBA | GO:0006357 | regulation of transcription by RNA polymerase II |
| BP | IBA | GO:0007010 | cytoskeleton organization |
| BP | IMP | GO:0007010 | cytoskeleton organization |
Gene expression in normal tissue: PHIP
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PHIP
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Database | Pathway ID | Pathway Des. |
|---|---|---|
| No matching records found | ||
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PHIP
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
CLASSFICATION
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