MYLK
Summary: This gene, a muscle member of the immunoglobulin gene superfamily, encodes myosin light chain kinase which is a calcium/calmodulin dependent enzyme. This kinase phosphorylates myosin regulatory light chains to facilitate myosin interaction with actin filaments to produce contractile activity. This gene encodes both smooth muscle and nonmuscle isoforms. In addition, using a separate promoter in an intron in the 3' region, it encodes telokin, a small protein identical in sequence to the C-terminus of myosin light chain kinase, that is independently expressed in smooth muscle and functions to stabilize unphosphorylated myosin filaments. A pseudogene is located on the p arm of chromosome 3. Four transcript variants that produce four isoforms of the calcium/calmodulin dependent enzyme have been identified as well as two transcripts that produce two isoforms of telokin. Additional variants have been identified but lack full length transcripts. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| myosin light chain kinase | MIM:600922 | Ensembl:ENSG00000065534 | HGNC:HGNC:7590 | PA31388 | 3q21.1 |
GO terms in MYLK
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IEA | GO:0003779 | actin binding |
| MF | IBA | GO:0004672 | protein kinase activity |
| MF | IBA | GO:0004687 | myosin light chain kinase activity |
| MF | IDA | GO:0004687 | myosin light chain kinase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005516 | calmodulin binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IEA | GO:0046872 | metal ion binding |
| CC | IBA | GO:0001725 | stress fiber |
| CC | IDA | GO:0001725 | stress fiber |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | TAS | GO:0005829 | cytosol |
| CC | IDA | GO:0005886 | plasma membrane |
| CC | IDA | GO:0015629 | actin cytoskeleton |
| CC | IBA | GO:0030027 | lamellipodium |
| CC | IDA | GO:0030027 | lamellipodium |
| CC | IBA | GO:0032154 | cleavage furrow |
| CC | IDA | GO:0032154 | cleavage furrow |
| BP | IEA | GO:0006468 | protein phosphorylation |
| BP | TAS | GO:0006936 | muscle contraction |
| BP | IBA | GO:0006939 | smooth muscle contraction |
| BP | ISS | GO:0006939 | smooth muscle contraction |
| BP | IBA | GO:0014820 | tonic smooth muscle contraction |
| BP | ISS | GO:0014820 | tonic smooth muscle contraction |
| BP | IDA | GO:0030335 | positive regulation of cell migration |
| BP | IMP | GO:0032060 | bleb assembly |
| BP | IDA | GO:0051928 | positive regulation of calcium ion transport |
| BP | IMP | GO:0060414 | aorta smooth muscle tissue morphogenesis |
| BP | IDA | GO:0071476 | cellular hypotonic response |
| BP | IBA | GO:0072358 | cardiovascular system development |
| BP | IDA | GO:0090303 | positive regulation of wound healing |
Gene expression in normal tissue: MYLK
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in MYLK
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| biocarta | biopeptidespathway | bioactive peptide induced signaling pathway |
| biocarta | ecmpathway | erk and pi-3 kinase are necessary for collagen binding in corneal epithelia |
| biocarta | mcalpainpathway | mcalpain and friends in cell motility |
| biocarta | myosinpathway | pkc-catalyzed phosphorylation of inhibitory phosphoprotein of myosin phosphatase |
| biocarta | rac1pathway | rac1 cell motility signaling pathway |
| biocarta | rhopathway | rho cell motility signaling pathway |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-194315 | Signaling by Rho GTPases |
| reactome | R-HSA-194315 | Signaling by Rho GTPases |
| reactome | R-HSA-195258 | RHO GTPase Effectors |
| reactome | R-HSA-195258 | RHO GTPase Effectors |
| reactome | R-HSA-397014 | Muscle contraction |
| reactome | R-HSA-445355 | Smooth Muscle Contraction |
| reactome | R-HSA-5627123 | RHO GTPases activate PAKs |
| reactome | R-HSA-5627123 | RHO GTPases activate PAKs |
| wikipathways | WP1544 | MicroRNAs in cardiomyocyte hypertrophy |
| wikipathways | WP2197 | Endothelin Pathways |
| wikipathways | WP306 | Focal Adhesion |
| wikipathways | WP3680 | Association Between Physico-Chemical Features and Toxicity Associated Pathways |
| wikipathways | WP51 | Regulation of Actin Cytoskeleton |
| smpdb | SMP00296 | Acebutolol Action Pathway |
| smpdb | SMP00297 | Alprenolol Action Pathway |
| smpdb | SMP00298 | Atenolol Action Pathway |
| smpdb | SMP00299 | Betaxolol Action Pathway |
| smpdb | SMP00300 | Bisoprolol Action Pathway |
| smpdb | SMP00301 | Esmolol Action Pathway |
| smpdb | SMP00302 | Metoprolol Action Pathway |
| smpdb | SMP00303 | Nadolol Action Pathway |
| smpdb | SMP00304 | Oxprenolol Action Pathway |
| smpdb | SMP00305 | Penbutolol Action Pathway |
| smpdb | SMP00306 | Pindolol Action Pathway |
| smpdb | SMP00307 | Propranolol Action Pathway |
| smpdb | SMP00323 | Quinidine Action Pathway |
| smpdb | SMP00324 | Procainamide (Antiarrhythmic) Action Pathway |
| smpdb | SMP00325 | Disopyramide Action Pathway |
| smpdb | SMP00326 | Fosphenytoin (Antiarrhythmic) Action Pathway |
| smpdb | SMP00327 | Phenytoin (Antiarrhythmic) Action Pathway |
| smpdb | SMP00328 | Lidocaine (Antiarrhythmic) Action Pathway |
| smpdb | SMP00329 | Mexiletine Action Pathway |
| smpdb | SMP00330 | Tocainide Action Pathway |
| smpdb | SMP00331 | Flecainide Action Pathway |
| smpdb | SMP00332 | Ibutilide Action Pathway |
| smpdb | SMP00354 | Intracellular Signalling Through Prostacyclin Receptor and Prostacyclin |
| smpdb | SMP00359 | Diltiazem Action Pathway |
| smpdb | SMP00366 | Nebivolol Action Pathway |
| smpdb | SMP00367 | Carvedilol Action Pathway |
| smpdb | SMP00368 | Labetalol Action Pathway |
| smpdb | SMP00375 | Verapamil Action Pathway |
| smpdb | SMP00376 | Amlodipine Action Pathway |
| smpdb | SMP00377 | Felodipine Action Pathway |
| smpdb | SMP00378 | Isradipine Action Pathway |
| smpdb | SMP00379 | Nifedipine Action Pathway |
| smpdb | SMP00380 | Nimodipine Action Pathway |
| smpdb | SMP00381 | Nisoldipine Action Pathway |
| smpdb | SMP00382 | Nitrendipine Action Pathway |
| smpdb | SMP00588 | Muscle/Heart Contraction |
| smpdb | SMP00657 | Bopindolol Action Pathway |
| smpdb | SMP00658 | Carteolol Action Pathway |
| smpdb | SMP00659 | Timolol Action Pathway |
| smpdb | SMP00660 | Sotalol Action Pathway |
| smpdb | SMP00661 | Epinephrine Action Pathway |
| smpdb | SMP00662 | Dobutamine Action Pathway |
| smpdb | SMP00663 | Isoprenaline Action Pathway |
| smpdb | SMP00664 | Arbutamine Action Pathway |
| smpdb | SMP00665 | Amiodarone Action Pathway |
| smpdb | SMP00666 | Levobunolol Action Pathway |
| smpdb | SMP00667 | Metipranolol Action Pathway |
| smpdb | SMP00668 | Bevantolol Action Pathway |
| smpdb | SMP00669 | Practolol Action Pathway |
| smpdb | SMP00670 | Bupranolol Action Pathway |
| pid | aurora_b_pathway | Aurora B signaling |
| kegg | hsa04020 | Calcium signaling pathway - Homo sapiens (human) |
| kegg | hsa04022 | cGMP-PKG signaling pathway - Homo sapiens (human) |
| kegg | hsa04270 | Vascular smooth muscle contraction - Homo sapiens (human) |
| kegg | hsa04371 | Apelin signaling pathway - Homo sapiens (human) |
| kegg | hsa04510 | Focal adhesion - Homo sapiens (human) |
| kegg | hsa04611 | Platelet activation - Homo sapiens (human) |
| kegg | hsa04810 | Regulation of actin cytoskeleton - Homo sapiens (human) |
| kegg | hsa04921 | Oxytocin signaling pathway - Homo sapiens (human) |
| kegg | hsa04971 | Gastric acid secretion - Homo sapiens (human) |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD434 | BMS-536924 | 2 |
| iGMDRD289 | Parthenolide | 5 |
| iGMDRD705 | Nakiterpiosin | 2 |
| iGMDRD105 | Triptolide | 5 |
| iGMDRD137 | Indisulam | 11 |
| iGMDRD103 | SN-38 | 6 |
| iGMDRD552 | AZD-1775 | 3 |
| iGMDRD246 | NPC26 | 7 |
| iGMDRD367 | Ro 28-1675 | 2 |
| iGMDRD286 | Nsc 632839 | 3 |
| iGMDRD345 | Compound 10b [PMID: 11504634] | 5 |
| iGMDRD424 | Tamatinib | 4 |
| iGMDRD116 | CD437 | 1 |
| iGMDRD583 | LDN 193189 | 1 |
| iGMDRD405 | PIK-75 | 2 |
| iGMDRD486 | Tosedostat | 2 |
| iGMDRD84 | Lovastatin acid | 3 |
| iGMDRD584 | VER 155008 | 2 |
| iGMDRD512 | nutlin 3 | 2 |
| iGMDRD123 | Isoevodiamine | 4 |
| iGMDRD945 | ML214 | 3 |
| iGMDRD237 | ABT-751 | 3 |
| iGMDRD138 | PX 12 | 4 |
| iGMDRD260 | FQI-2 | 1 |
| iGMDRD255 | SB225002 | 3 |
| iGMDRD64 | Parbendazole | 5 |
| iGMDRD524 | ISX-9 | 2 |
| iGMDRD356 | PNU-74654 | 2 |
| iGMDRD74 | Idarubicin | 6 |
| iGMDRD188 | Piperlongumine | 5 |
| iGMDRD546 | BMS-754807 | 2 |
| iGMDRD781 | Sirolimus | 4 |
| iGMDRD151 | CHM-1 | 4 |
| iGMDRD433 | Lexibulin | 6 |
| iGMDRD126 | Tipifarnib | 3 |
| iGMDRD772 | BRD4770 | 2 |
| iGMDRD420 | Leucascandrolide A | 3 |
| iGMDRD466 | Chaetocin | 5 |
| iGMDRD446 | LY 2183240 | 3 |
| iGMDRD193 | Fqi1 | 4 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in MYLK
CLASSFICATION
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