MAPK4


Summary: Mitogen-activated protein kinase 4 is a member of the mitogen-activated protein kinase family. Tyrosine kinase growth factor receptors activate mitogen-activated protein kinases which then translocate into the nucleus and phosphorylate nuclear targets. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
mitogen-activated protein kinase 4MIM:176949Ensembl:ENSG00000141639HGNC:HGNC:6878PA3062318q21.1-q21.2

GO terms in MAPK4


Term TypeEvidence TypeGO Term IDGO Des.
MFTASGO:0004674protein serine/threonine kinase activity
MFIBAGO:0004707MAP kinase activity
MFIPIGO:0005515protein binding
MFIEAGO:0005524ATP binding
MFISSGO:0019901protein kinase binding
MFISSGO:0042803protein homodimerization activity
MFIEAGO:0046982protein heterodimerization activity
CCIBAGO:0005634nucleus
CCISSGO:0005634nucleus
CCTASGO:0005654nucleoplasm
CCIBAGO:0005737cytoplasm
CCISSGO:0005737cytoplasm
CCTASGO:0005829cytosol
BPIEAGO:0000165MAPK cascade
BPTASGO:0006468protein phosphorylation
BPIEAGO:0007049cell cycle
BPIBAGO:0007166cell surface receptor signaling pathway
BPIBAGO:0010468regulation of gene expression
BPIBAGO:0035556intracellular signal transduction
BPIBAGO:0071310cellular response to organic substance

Gene expression in normal tissue: MAPK4

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in MAPK4


DatabasePathway IDPathway Des.
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-5683057MAPK family signaling cascades
reactomeR-HSA-5687128MAPK6/MAPK4 signaling
kegghsa04657IL-17 signaling pathway - Homo sapiens (human)
pharmgkbPA2032VEGF Signaling Pathway
wikipathwaysWP1544MicroRNAs in cardiomyocyte hypertrophy
wikipathwaysWP185Integrin-mediated Cell Adhesion
wikipathwaysWP23B Cell Receptor Signaling Pathway
wikipathwaysWP26Signal Transduction of S1P Receptor
wikipathwaysWP366TGF-beta Signaling Pathway
wikipathwaysWP3915Angiopoietin Like Protein 8 Regulatory Pathway
wikipathwaysWP3931ESC Pluripotency Pathways
wikipathwaysWP4148Splicing factor NOVA regulated synaptic proteins
wikipathwaysWP437EGF-EGFR Signaling Pathway
wikipathwaysWP481Insulin Signaling
wikipathwaysWP51Regulation of Actin Cytoskeleton

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD213SMR0000686501
iGMDRD782DC-45-A23
iGMDRD192CIL563
iGMDRD42Vorinostat2
iGMDRD356PNU-746542
iGMDRD598QS-113
iGMDRD23Gossypol2
iGMDRD505Pevonedistat2
iGMDRD562Navitoclax2
iGMDRD780PP-303
iGMDRD577BIX012941
iGMDRD329Merck602
iGMDRD74Idarubicin3
iGMDRD286Nsc 6328392
iGMDRD781Sirolimus6
iGMDRD345Compound 10b [PMID: 11504634]1
iGMDRD560MK-22062
iGMDRD532Olaparib3
iGMDRD116CD4371
iGMDRD607Ubistatin B4
iGMDRD126Tipifarnib3
iGMDRD48Dexamethasone3
iGMDRD123Isoevodiamine3
iGMDRD280CYTOCHALASIN B1
iGMDRD193Fqi12
iGMDRD536PLX-47201
iGMDRD639YK 4-2791
iGMDRD446LY 21832402

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in MAPK4

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