TOP2A


Summary: This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, alpha, is localized to chromosome 17 and the beta gene is localized to chromosome 3. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia. [provided by RefSeq, Jul 2010].

Loading, please wait...
Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
OMIM IDMIM:126430
PHARMGKB IDPA354
Map Location17q21.2

GO terms in TOP2A


Loading, please wait...
Term Type
Evidence Type
GO Term ID
GO Des.
BP IBA GO:0000712 resolution of meiotic recombination intermediates
BP IBA GO:0000819 sister chromatid segregation
BP IEA GO:0002244 hematopoietic progenitor cell differentiation
BP IDA GO:0006265 DNA topological change
BP IMP GO:0006265 DNA topological change
BP IDA GO:0006266 DNA ligation
Showing 1 to 6 of 50 rows rows per page

Gene expression in normal tissue: TOP2A

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

undefined41PI3K/MTOR signaling2Cell cycle2Purine metabolism1Ferroptosis1Mitosis1Apoptosis regulation1ERK MAPK signaling1WNT signaling1Longevity regulating pathway1

Pathways in TOP2A


Loading, please wait...
Database
Pathway ID
Pathway Des.
wikipathways WP1858 Mitotic G1-G1-S phases
wikipathways WP2361 Gastric Cancer Network 1
wikipathways WP2363 Gastric Cancer Network 2
wikipathways WP2446 Retinoblastoma (RB) in Cancer
smpdb SMP00442 Etoposide Action Pathway
smpdb SMP00443 Teniposide Action Pathway
Showing 1 to 6 of 26 rows rows per page

Gene-Drug: Aster Plot


Loading, please wait...
Drug ID
Drug Name
Model Num.
iGMDRD427 ABT737 5
iGMDRD670 ML 210 3
iGMDRD779 PRL-3 Inhibitor I 1
iGMDRD781 Sirolimus 3
Showing 1 to 4 of 56 rows rows per page

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in TOP2A

Loading, please wait...
Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

​​​​