TOP2A
Summary: This gene encodes a DNA topoisomerase, an enzyme that controls and alters the topologic states of DNA during transcription. This nuclear enzyme is involved in processes such as chromosome condensation, chromatid separation, and the relief of torsional stress that occurs during DNA transcription and replication. It catalyzes the transient breaking and rejoining of two strands of duplex DNA which allows the strands to pass through one another, thus altering the topology of DNA. Two forms of this enzyme exist as likely products of a gene duplication event. The gene encoding this form, alpha, is localized to chromosome 17 and the beta gene is localized to chromosome 3. The gene encoding this enzyme functions as the target for several anticancer agents and a variety of mutations in this gene have been associated with the development of drug resistance. Reduced activity of this enzyme may also play a role in ataxia-telangiectasia. [provided by RefSeq, Jul 2010].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
---|---|---|---|---|---|
OMIM IDMIM:126430 Ensembl IDEnsembl:ENSG00000131747 HGNC IDHGNC:HGNC:11989 PHARMGKB IDPA354 Map Location17q21.2 |
GO terms in TOP2A
Term Type | Evidence Type | GO Term ID | GO Des. |
---|---|---|---|
BP | IBA | GO:0000712 | resolution of meiotic recombination intermediates |
BP | IBA | GO:0000819 | sister chromatid segregation |
BP | IEA | GO:0002244 | hematopoietic progenitor cell differentiation |
BP | IDA | GO:0006265 | DNA topological change |
BP | IMP | GO:0006265 | DNA topological change |
BP | IDA | GO:0006266 | DNA ligation |
Gene expression in normal tissue: TOP2A
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in TOP2A
Database | Pathway ID | Pathway Des. |
---|---|---|
wikipathways | WP1858 | Mitotic G1-G1-S phases |
wikipathways | WP2361 | Gastric Cancer Network 1 |
wikipathways | WP2363 | Gastric Cancer Network 2 |
wikipathways | WP2446 | Retinoblastoma (RB) in Cancer |
smpdb | SMP00442 | Etoposide Action Pathway |
smpdb | SMP00443 | Teniposide Action Pathway |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot

Gene-drug targets distribution
Gene Structure: PDB
Models in TOP2A
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
---|---|---|---|---|---|---|---|---|
No matching records found |