KLK7
Summary: This gene encodes a member of the kallikrein subfamily of serine proteases. These enzymes have diverse physiological functions and many kallikrein genes are biomarkers for cancer. The encoded protein has chymotrypsin-like activity and plays a role in the proteolysis of intercellular cohesive structures that precedes desquamation, the shedding of the outermost layer of the epidermis. The encoded protein may play a role in cancer invasion and metastasis, and increased expression of this gene is associated with unfavorable prognosis and progression of several types of cancer. Polymorphisms in this gene may play a role in the development of atopic dermatitis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, which is one of fifteen kallikrein subfamily members located in a gene cluster on chromosome 19. [provided by RefSeq, May 2011].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| kallikrein related peptidase 7 | MIM:604438 | Ensembl:ENSG00000169035 | HGNC:HGNC:6368 | PA30157 | 19q13.41 |
GO terms in KLK7
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | TAS | GO:0004222 | metalloendopeptidase activity |
| MF | IEA | GO:0004252 | serine-type endopeptidase activity |
| MF | IMP | GO:0008233 | peptidase activity |
| MF | TAS | GO:0008236 | serine-type peptidase activity |
| BP | IBA | GO:0002803 | positive regulation of antibacterial peptide production |
| BP | IMP | GO:0002803 | positive regulation of antibacterial peptide production |
| BP | IEA | GO:0006508 | proteolysis |
| BP | TAS | GO:0008544 | epidermis development |
| BP | TAS | GO:0022617 | extracellular matrix disassembly |
| CC | TAS | GO:0005576 | extracellular region |
| CC | IMP | GO:0005615 | extracellular space |
| CC | IBA | GO:0030141 | secretory granule |
| CC | IDA | GO:0097209 | epidermal lamellar body |
Gene expression in normal tissue: KLK7
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in KLK7
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1474228 | Degradation of the extracellular matrix |
| reactome | R-HSA-1474244 | Extracellular matrix organization |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD79 | Gemcitabine | 1 |
| iGMDRD150 | RITA | 8 |
| iGMDRD532 | Olaparib | 2 |
| iGMDRD345 | Compound 10b [PMID: 11504634] | 1 |
| iGMDRD84 | Lovastatin acid | 3 |
| iGMDRD351 | GW843682X | 2 |
| iGMDRD415 | LE-135 | 2 |
| iGMDRD267 | Oligomycin A | 2 |
| iGMDRD158 | NSC141540 | 3 |
| iGMDRD137 | Indisulam | 3 |
| iGMDRD82 | Quiflapon | 2 |
| iGMDRD300 | Tozasertib | 3 |
| iGMDRD886 | Compound 1541A | 2 |
| iGMDRD329 | Merck60 | 8 |
| iGMDRD286 | Nsc 632839 | 2 |
| iGMDRD367 | Ro 28-1675 | 2 |
| iGMDRD872 | BRD7137 | 3 |
| iGMDRD484 | Pluripotin | 3 |
| iGMDRD144 | NSC95397 | 3 |
| iGMDRD634 | SCHEMBL2608041 | 3 |
| iGMDRD280 | CYTOCHALASIN B | 6 |
| iGMDRD466 | Chaetocin | 2 |
| iGMDRD748 | PHA-665752 | 1 |
| iGMDRD318 | PAC-1 | 2 |
| iGMDRD294 | Batimastat | 1 |
| iGMDRD513 | BML-259 | 2 |
| iGMDRD23 | Gossypol | 3 |
| iGMDRD356 | PNU-74654 | 2 |
| iGMDRD524 | ISX-9 | 2 |
| iGMDRD577 | BIX01294 | 5 |
| iGMDRD398 | Sepantronium | 3 |
| iGMDRD100 | Zebularine | 5 |
| iGMDRD188 | Piperlongumine | 3 |
| iGMDRD74 | Idarubicin | 7 |
| iGMDRD887 | Compound 23 citrate | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in KLK7
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