RIPK4
Summary: The protein encoded by this gene is a serine/threonine protein kinase that interacts with protein kinase C-delta. The encoded protein can also activate NFkappaB and is required for keratinocyte differentiation. This kinase undergoes autophosphorylation. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| receptor interacting serine/threonine kinase 4 | MIM:605706 | Ensembl:ENSG00000183421 | HGNC:HGNC:496 | PA24805 | 21q22.3 |
GO terms in RIPK4
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IMP | GO:0002009 | morphogenesis of an epithelium |
| BP | IEA | GO:0006468 | protein phosphorylation |
| BP | IMP | GO:0051092 | positive regulation of NF-kappaB transcription factor activity |
| CC | ISS | GO:0005737 | cytoplasm |
| CC | IEA | GO:0016020 | membrane |
| MF | IEA | GO:0004674 | protein serine/threonine kinase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
Gene expression in normal tissue: RIPK4
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in RIPK4
| Database | Pathway ID | Pathway Des. |
|---|
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD237 | ABT-751 | 3 |
| iGMDRD341 | Triacsin c | 6 |
| iGMDRD85 | Ursolic acid | 2 |
| iGMDRD435 | BI-2536 | 3 |
| iGMDRD901 | ELCPK | 3 |
| iGMDRD123 | Isoevodiamine | 2 |
| iGMDRD177 | Teniposide | 3 |
| iGMDRD512 | nutlin 3 | 3 |
| iGMDRD607 | Ubistatin B | 2 |
| iGMDRD584 | VER 155008 | 2 |
| iGMDRD84 | Lovastatin acid | 3 |
| iGMDRD701 | NVP-AUY922 | 3 |
| iGMDRD79 | Gemcitabine | 3 |
| iGMDRD560 | MK-2206 | 3 |
| iGMDRD532 | Olaparib | 3 |
| iGMDRD345 | Compound 10b [PMID: 11504634] | 3 |
| iGMDRD329 | Merck60 | 2 |
| iGMDRD269 | Purmorphamine | 2 |
| iGMDRD871 | BRD6368 | 2 |
| iGMDRD367 | Ro 28-1675 | 3 |
| iGMDRD552 | AZD-1775 | 3 |
| iGMDRD246 | NPC26 | 3 |
| iGMDRD5 | Tyrphostin AG 1478 | 2 |
| iGMDRD481 | Dactolisib | 3 |
| iGMDRD415 | LE-135 | 3 |
| iGMDRD77 | Itraconazole | 2 |
| iGMDRD639 | YK 4-279 | 3 |
| iGMDRD316 | N9-Isopropyl-olomoucine | 2 |
| iGMDRD152 | 179324-69-7 | 3 |
| iGMDRD193 | Fqi1 | 3 |
| iGMDRD163 | all trans Retinoic Acid | 2 |
| iGMDRD297 | Austocystin D | 8 |
| iGMDRD126 | Tipifarnib | 4 |
| iGMDRD151 | CHM-1 | 3 |
| iGMDRD210 | AC55649 | 1 |
| iGMDRD433 | Lexibulin | 3 |
| iGMDRD494 | Neopeltolide | 2 |
| iGMDRD577 | BIX01294 | 2 |
| iGMDRD398 | Sepantronium | 2 |
| iGMDRD730 | Kahalalide F | 3 |
| iGMDRD74 | Idarubicin | 3 |
| iGMDRD356 | PNU-74654 | 2 |
| iGMDRD23 | Gossypol | 3 |
| iGMDRD131 | Erlotinib | 1 |
| iGMDRD64 | Parbendazole | 2 |
| iGMDRD60 | Quinoclamine | 3 |
| iGMDRD513 | BML-259 | 3 |
| iGMDRD294 | Batimastat | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in RIPK4
CLASSFICATION
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