RIPK4


Summary: The protein encoded by this gene is a serine/threonine protein kinase that interacts with protein kinase C-delta. The encoded protein can also activate NFkappaB and is required for keratinocyte differentiation. This kinase undergoes autophosphorylation. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
receptor interacting serine/threonine kinase 4MIM:605706Ensembl:ENSG00000183421HGNC:HGNC:496PA2480521q22.3

GO terms in RIPK4


Term TypeEvidence TypeGO Term IDGO Des.
BPIMPGO:0002009morphogenesis of an epithelium
BPIEAGO:0006468protein phosphorylation
BPIMPGO:0051092positive regulation of NF-kappaB transcription factor activity
CCISSGO:0005737cytoplasm
CCIEAGO:0016020membrane
MFIEAGO:0004674protein serine/threonine kinase activity
MFIPIGO:0005515protein binding
MFIEAGO:0005524ATP binding

Gene expression in normal tissue: RIPK4

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in RIPK4


DatabasePathway IDPathway Des.

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD237ABT-7513
iGMDRD341Triacsin c6
iGMDRD85Ursolic acid2
iGMDRD435BI-25363
iGMDRD901ELCPK3
iGMDRD123Isoevodiamine2
iGMDRD177Teniposide3
iGMDRD512nutlin 33
iGMDRD607Ubistatin B2
iGMDRD584VER 1550082
iGMDRD84Lovastatin acid3
iGMDRD701NVP-AUY9223
iGMDRD79Gemcitabine3
iGMDRD560MK-22063
iGMDRD532Olaparib3
iGMDRD345Compound 10b [PMID: 11504634]3
iGMDRD329Merck602
iGMDRD269Purmorphamine2
iGMDRD871BRD63682
iGMDRD367Ro 28-16753
iGMDRD552AZD-17753
iGMDRD246NPC263
iGMDRD5Tyrphostin AG 14782
iGMDRD481Dactolisib3
iGMDRD415LE-1353
iGMDRD77Itraconazole2
iGMDRD639YK 4-2793
iGMDRD316N9-Isopropyl-olomoucine2
iGMDRD152179324-69-73
iGMDRD193Fqi13
iGMDRD163all trans Retinoic Acid2
iGMDRD297Austocystin D8
iGMDRD126Tipifarnib4
iGMDRD151CHM-13
iGMDRD210AC556491
iGMDRD433Lexibulin3
iGMDRD494Neopeltolide2
iGMDRD577BIX012942
iGMDRD398Sepantronium2
iGMDRD730Kahalalide F3
iGMDRD74Idarubicin3
iGMDRD356PNU-746542
iGMDRD23Gossypol3
iGMDRD131Erlotinib1
iGMDRD64Parbendazole2
iGMDRD60Quinoclamine3
iGMDRD513BML-2593
iGMDRD294Batimastat3

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in RIPK4

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