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WNK4

Summary: This gene encodes a member of the WNK family of serine-threonine protein kinases. The kinase is part of the tight junction complex in kidney cells, and regulates the balance between NaCl reabsorption and K(+) secretion. The kinase regulates the activities of several types of ion channels, cotransporters, and exchangers involved in electrolyte flux in epithelial cells. Mutations in this gene result in pseudohypoaldosteronism type IIB.[provided by RefSeq, Sep 2009].

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Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
NameWNK lysine deficient protein kinase 4 OMIM IDMIM:601844 Ensembl IDEnsembl:ENSG00000126562 HGNC IDHGNC:HGNC:14544 PHARMGKB IDPA134875400 Map Location17q21.2

Gene Categories:

TRANSPORTER DRUGGABLE GENOME ION CHANNEL KINASE SERINE THREONINE KINASE

GO terms in WNK4

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Term Type	Evidence Type	GO Term ID	GO Des.
BP	IBA	GO:0006468	protein phosphorylation
BP	ISS	GO:0006468	protein phosphorylation
BP	ISS	GO:0006811	ion transport
BP	IEA	GO:0006821	chloride transport
BP	IEA	GO:0008104	protein localization
BP	ISS	GO:0010766	negative regulation of sodium ion transport

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Gene expression in normal tissue: WNK4

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in WNK4

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Database	Pathway ID	Pathway Des.
reactome	R-HSA-2672351	Stimuli-sensing channels
reactome	R-HSA-382551	Transport of small molecules
reactome	R-HSA-983712	Ion channel transport
pharmgkb	PA165984799	Diuretics Pathway, Pharmacodynamics

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Gene-Drug: Aster Plot

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Drug ID	Drug Name	Model Num.
iGMDRD52	Rotenone	2
iGMDRD870	BRD63610	1
iGMDRD705	Nakiterpiosin	4
iGMDRD260	FQI-2	2

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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in WNK4

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	Model	Level	Reference ID	Tissue	Cancer	Drug	Clinical Response	Source
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