WNK4
Summary: This gene encodes a member of the WNK family of serine-threonine protein kinases. The kinase is part of the tight junction complex in kidney cells, and regulates the balance between NaCl reabsorption and K(+) secretion. The kinase regulates the activities of several types of ion channels, cotransporters, and exchangers involved in electrolyte flux in epithelial cells. Mutations in this gene result in pseudohypoaldosteronism type IIB.[provided by RefSeq, Sep 2009].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| WNK lysine deficient protein kinase 4 | MIM:601844 | Ensembl:ENSG00000126562 | HGNC:HGNC:14544 | PA134875400 | 17q21.2 |
GO terms in WNK4
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IBA | GO:0006468 | protein phosphorylation |
| BP | ISS | GO:0006468 | protein phosphorylation |
| BP | ISS | GO:0006811 | ion transport |
| BP | IEA | GO:0006821 | chloride transport |
| BP | IEA | GO:0008104 | protein localization |
| BP | ISS | GO:0010766 | negative regulation of sodium ion transport |
| BP | IBA | GO:0032414 | positive regulation of ion transmembrane transporter activity |
| BP | IBA | GO:0035556 | intracellular signal transduction |
| BP | ISS | GO:0035556 | intracellular signal transduction |
| BP | ISS | GO:0050794 | regulation of cellular process |
| BP | IMP | GO:0050801 | ion homeostasis |
| BP | IBA | GO:0070294 | renal sodium ion absorption |
| BP | IMP | GO:0070294 | renal sodium ion absorption |
| BP | IMP | GO:0072156 | distal tubule morphogenesis |
| BP | IEA | GO:0090188 | negative regulation of pancreatic juice secretion |
| CC | IBA | GO:0005829 | cytosol |
| CC | ISS | GO:0005829 | cytosol |
| CC | ISS | GO:0005923 | bicellular tight junction |
| CC | ISS | GO:0016020 | membrane |
| MF | IBA | GO:0004674 | protein serine/threonine kinase activity |
| MF | ISS | GO:0004674 | protein serine/threonine kinase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | ISS | GO:0005524 | ATP binding |
| MF | IDA | GO:0019869 | chloride channel inhibitor activity |
Gene expression in normal tissue: WNK4
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in WNK4
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-2672351 | Stimuli-sensing channels |
| reactome | R-HSA-382551 | Transport of small molecules |
| reactome | R-HSA-983712 | Ion channel transport |
| pharmgkb | PA165984799 | Diuretics Pathway, Pharmacodynamics |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD52 | Rotenone | 2 |
| iGMDRD870 | BRD63610 | 1 |
| iGMDRD705 | Nakiterpiosin | 4 |
| iGMDRD260 | FQI-2 | 2 |
| iGMDRD121 | GMX1778 | 2 |
| iGMDRD158 | NSC141540 | 3 |
| iGMDRD137 | Indisulam | 2 |
| iGMDRD356 | PNU-74654 | 2 |
| iGMDRD505 | Pevonedistat | 2 |
| iGMDRD64 | Parbendazole | 2 |
| iGMDRD329 | Merck60 | 3 |
| iGMDRD506 | Fedratinib | 4 |
| iGMDRD79 | Gemcitabine | 1 |
| iGMDRD345 | Compound 10b [PMID: 11504634] | 3 |
| iGMDRD420 | Leucascandrolide A | 2 |
| iGMDRD151 | CHM-1 | 4 |
| iGMDRD634 | SCHEMBL2608041 | 2 |
| iGMDRD511 | CHEMBL399379 | 3 |
| iGMDRD435 | BI-2536 | 4 |
| iGMDRD901 | ELCPK | 4 |
| iGMDRD177 | Teniposide | 3 |
| iGMDRD123 | Isoevodiamine | 2 |
| iGMDRD394 | BX-795 | 4 |
| iGMDRD351 | GW843682X | 3 |
| iGMDRD314 | Tanespimycin | 2 |
| iGMDRD193 | Fqi1 | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in WNK4
CLASSFICATION
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