KDM5A
Summary: This gene encodes a member of the Jumonji, AT-rich interactive domain 1 (JARID1) histone demethylase protein family. The encoded protein plays a role in gene regulation through the histone code by specifically demethylating lysine 4 of histone H3. The encoded protein interacts with many other proteins, including retinoblastoma protein, and is implicated in the transcriptional regulation of Hox genes and cytokines. This gene may play a role in tumor progression. [provided by RefSeq, Aug 2013].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| lysine demethylase 5A | MIM:180202 | Ensembl:ENSG00000073614 | HGNC:HGNC:9886 | PA34250 | 12p13.33 |
GO terms in KDM5A
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IEA | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| BP | TAS | GO:0006366 | transcription by RNA polymerase II |
| BP | IEA | GO:0007283 | spermatogenesis |
| BP | IEA | GO:0008584 | male gonad development |
| BP | ISS | GO:0032922 | circadian regulation of gene expression |
| BP | IDA | GO:0033169 | histone H3-K9 demethylation |
| BP | IDA | GO:0034720 | histone H3-K4 demethylation |
| BP | IEA | GO:0034721 | histone H3-K4 demethylation, trimethyl-H3-K4-specific |
| BP | IDA | GO:0045893 | positive regulation of transcription, DNA-templated |
| BP | IMP | GO:0051090 | regulation of DNA-binding transcription factor activity |
| BP | IEA | GO:0055114 | oxidation-reduction process |
| BP | ISS | GO:1901726 | negative regulation of histone deacetylase activity |
| CC | IBA | GO:0005634 | nucleus |
| CC | IDA | GO:0005634 | nucleus |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IEA | GO:0005730 | nucleolus |
| CC | IDA | GO:0019907 | cyclin-dependent protein kinase activating kinase holoenzyme complex |
| CC | IEA | GO:0032993 | protein-DNA complex |
| CC | IBA | GO:0035097 | histone methyltransferase complex |
| MF | ISA | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | IMP | GO:0001046 | core promoter sequence-specific DNA binding |
| MF | IBA | GO:0001227 | transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific DNA binding |
| MF | IDA | GO:0003677 | DNA binding |
| MF | IBA | GO:0003682 | chromatin binding |
| MF | IMP | GO:0003700 | DNA-binding transcription factor activity |
| MF | ISS | GO:0003713 | transcription coactivator activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IDA | GO:0008270 | zinc ion binding |
| MF | IEA | GO:0031490 | chromatin DNA binding |
| MF | IBA | GO:0032452 | histone demethylase activity |
| MF | TAS | GO:0032452 | histone demethylase activity |
| MF | IDA | GO:0032454 | histone demethylase activity (H3-K9 specific) |
| MF | IBA | GO:0034647 | histone demethylase activity (H3-trimethyl-K4 specific) |
| MF | IDA | GO:0034647 | histone demethylase activity (H3-trimethyl-K4 specific) |
| MF | IDA | GO:0034648 | histone demethylase activity (H3-dimethyl-K4 specific) |
| MF | IBA | GO:0035064 | methylated histone binding |
| MF | IDA | GO:0035064 | methylated histone binding |
| MF | IDA | GO:0042393 | histone binding |
| MF | IEA | GO:0051213 | dioxygenase activity |
Gene expression in normal tissue: KDM5A
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in KDM5A
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-3214842 | HDMs demethylate histones |
| reactome | R-HSA-3247509 | Chromatin modifying enzymes |
| reactome | R-HSA-4839726 | Chromatin organization |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD100 | Zebularine | 3 |
| iGMDRD188 | Piperlongumine | 6 |
| iGMDRD74 | Idarubicin | 6 |
| iGMDRD887 | Compound 23 citrate | 2 |
| iGMDRD577 | BIX01294 | 2 |
| iGMDRD64 | Parbendazole | 8 |
| iGMDRD356 | PNU-74654 | 3 |
| iGMDRD451 | Serdemetan | 5 |
| iGMDRD138 | PX 12 | 7 |
| iGMDRD260 | FQI-2 | 5 |
| iGMDRD171 | Pemetrexed | 3 |
| iGMDRD226 | ML006 | 3 |
| iGMDRD187 | BRD9876 | 3 |
| iGMDRD294 | Batimastat | 2 |
| iGMDRD446 | LY 2183240 | 3 |
| iGMDRD201 | SKI II | 3 |
| iGMDRD193 | Fqi1 | 7 |
| iGMDRD280 | CYTOCHALASIN B | 5 |
| iGMDRD466 | Chaetocin | 5 |
| iGMDRD151 | CHM-1 | 5 |
| iGMDRD433 | Lexibulin | 6 |
| iGMDRD420 | Leucascandrolide A | 2 |
| iGMDRD1008 | SR-II-138A | 6 |
| iGMDRD427 | ABT737 | 3 |
| iGMDRD144 | NSC95397 | 3 |
| iGMDRD779 | PRL-3 Inhibitor I | 3 |
| iGMDRD483 | SCH-529074 | 4 |
| iGMDRD286 | Nsc 632839 | 6 |
| iGMDRD329 | Merck60 | 3 |
| iGMDRD505 | Pevonedistat | 6 |
| iGMDRD246 | NPC26 | 2 |
| iGMDRD103 | SN-38 | 3 |
| iGMDRD137 | Indisulam | 5 |
| iGMDRD158 | NSC141540 | 2 |
| iGMDRD121 | GMX1778 | 2 |
| iGMDRD202 | Curcumin | 3 |
| iGMDRD5 | Tyrphostin AG 1478 | 4 |
| iGMDRD705 | Nakiterpiosin | 5 |
| iGMDRD289 | Parthenolide | 2 |
| iGMDRD481 | Dactolisib | 3 |
| iGMDRD85 | Ursolic acid | 4 |
| iGMDRD351 | GW843682X | 4 |
| iGMDRD237 | ABT-751 | 4 |
| iGMDRD901 | ELCPK | 3 |
| iGMDRD123 | Isoevodiamine | 5 |
| iGMDRD945 | ML214 | 5 |
| iGMDRD84 | Lovastatin acid | 2 |
| iGMDRD486 | Tosedostat | 2 |
| iGMDRD148 | Pifithrin-mu | 3 |
| iGMDRD116 | CD437 | 2 |
| iGMDRD150 | RITA | 3 |
| iGMDRD345 | Compound 10b [PMID: 11504634] | 6 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in KDM5A
CLASSFICATION
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