KDM5A

Summary: This gene encodes a member of the Jumonji, AT-rich interactive domain 1 (JARID1) histone demethylase protein family. The encoded protein plays a role in gene regulation through the histone code by specifically demethylating lysine 4 of histone H3. The encoded protein interacts with many other proteins, including retinoblastoma protein, and is implicated in the transcriptional regulation of Hox genes and cytokines. This gene may play a role in tumor progression. [provided by RefSeq, Aug 2013].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Namelysine demethylase 5A
OMIM IDMIM:180202
Ensembl IDEnsembl:ENSG00000073614
HGNC IDHGNC:HGNC:9886
PHARMGKB IDPA34250
Map Location12p13.33

GO terms in KDM5A


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Term Type
Evidence Type
GO Term ID
GO Des.
BP IEA GO:0000122 negative regulation of transcription by RNA polymerase II
BP TAS GO:0006366 transcription by RNA polymerase II
BP IEA GO:0007283 spermatogenesis
BP IEA GO:0008584 male gonad development
BP ISS GO:0032922 circadian regulation of gene expression
BP IDA GO:0033169 histone H3-K9 demethylation
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Gene expression in normal tissue: KDM5A

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

undefined43DNA replication2PI3K/MTOR signaling1Cell cycle1Chromatin histone acetylation1Stilbenoid, diarylheptanoid and gingerol biosynthesis1Leukocyte transendothelial migration1p53 pathway1One carbon pool by folate1

Pathways in KDM5A


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Database
Pathway ID
Pathway Des.
reactome R-HSA-3214842 HDMs demethylate histones
reactome R-HSA-3247509 Chromatin modifying enzymes
reactome R-HSA-4839726 Chromatin organization
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD100 Zebularine 3
iGMDRD188 Piperlongumine 6
iGMDRD74 Idarubicin 6
iGMDRD887 Compound 23 citrate 2
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in KDM5A

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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