RXRA
Summary: Retinoid X receptors (RXRs) and retinoic acid receptors (RARs) are nuclear receptors that mediate the biological effects of retinoids by their involvement in retinoic acid-mediated gene activation. These receptors function as transcription factors by binding as homodimers or heterodimers to specific sequences in the promoters of target genes. The protein encoded by this gene is a member of the steroid and thyroid hormone receptor superfamily of transcriptional regulators. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, May 2014].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| retinoid X receptor alpha | MIM:180245 | Ensembl:ENSG00000186350 | HGNC:HGNC:10477 | PA34890 | 9q34.2 |
GO terms in RXRA
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IDA | GO:0000790 | nuclear chromatin |
| CC | IDA | GO:0005634 | nucleus |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IDA | GO:0032991 | protein-containing complex |
| CC | IDA | GO:0043235 | receptor complex |
| CC | IDA | GO:0090575 | RNA polymerase II transcription factor complex |
| BP | IDA | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| BP | IEA | GO:0001701 | in utero embryonic development |
| BP | IEA | GO:0001893 | maternal placenta development |
| BP | TAS | GO:0006367 | transcription initiation from RNA polymerase II promoter |
| BP | TAS | GO:0006766 | vitamin metabolic process |
| BP | IEA | GO:0007566 | embryo implantation |
| BP | TAS | GO:0008203 | cholesterol metabolic process |
| BP | TAS | GO:0015721 | bile acid and bile salt transport |
| BP | IDA | GO:0019048 | modulation by virus of host morphology or physiology |
| BP | TAS | GO:0019216 | regulation of lipid metabolic process |
| BP | IMP | GO:0032526 | response to retinoic acid |
| BP | IDA | GO:0035357 | peroxisome proliferator activated receptor signaling pathway |
| BP | IEA | GO:0043010 | camera-type eye development |
| BP | IEA | GO:0043401 | steroid hormone mediated signaling pathway |
| BP | IDA | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IEA | GO:0045994 | positive regulation of translational initiation by iron |
| BP | IMP | GO:0048384 | retinoic acid receptor signaling pathway |
| BP | IDA | GO:0051289 | protein homotetramerization |
| BP | IEA | GO:0055010 | ventricular cardiac muscle tissue morphogenesis |
| BP | IEA | GO:0055012 | ventricular cardiac muscle cell differentiation |
| BP | IEA | GO:0060038 | cardiac muscle cell proliferation |
| BP | IEA | GO:0060528 | secretory columnal luminar epithelial cell differentiation involved in prostate glandular acinus development |
| BP | IEA | GO:0060687 | regulation of branching involved in prostate gland morphogenesis |
| BP | IEA | GO:1901522 | positive regulation of transcription from RNA polymerase II promoter involved in cellular response to chemical stimulus |
| MF | IDA | GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding |
| MF | ISA | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | ISM | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | NAS | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | IDA | GO:0001972 | retinoic acid binding |
| MF | IDA | GO:0003677 | DNA binding |
| MF | IMP | GO:0003690 | double-stranded DNA binding |
| MF | IDA | GO:0003700 | DNA-binding transcription factor activity |
| MF | IDA | GO:0003700 | DNA-binding transcription factor activity |
| MF | IEA | GO:0003707 | steroid hormone receptor activity |
| MF | TAS | GO:0003708 | retinoic acid receptor activity |
| MF | TAS | GO:0003713 | transcription coactivator activity |
| MF | IDA | GO:0004879 | nuclear receptor activity |
| MF | IEA | GO:0004886 | 9-cis retinoic acid receptor activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IDA | GO:0008270 | zinc ion binding |
| MF | IPI | GO:0016922 | nuclear receptor binding |
| MF | IPI | GO:0019899 | enzyme binding |
| MF | IEA | GO:0031490 | chromatin DNA binding |
| MF | IDA | GO:0042277 | peptide binding |
| MF | IPI | GO:0042809 | vitamin D receptor binding |
| MF | IDA | GO:0043565 | sequence-specific DNA binding |
| MF | IDA | GO:0044212 | transcription regulatory region DNA binding |
| MF | IDA | GO:0044323 | retinoic acid-responsive element binding |
| MF | IDA | GO:0046982 | protein heterodimerization activity |
| MF | IDA | GO:0050692 | DBD domain binding |
| MF | IDA | GO:0050693 | LBD domain binding |
| MF | IDA | GO:0070644 | vitamin D response element binding |
Gene expression in normal tissue: RXRA
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in RXRA
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| biocarta | carm1pathway | transcription regulation by methyltransferase of carm1 |
| biocarta | pparapathway | mechanism of gene regulation by peroxisome proliferators via ppara |
| biocarta | ppargpathway | role of ppar-gamma coactivators in obesity and thermogenesis |
| biocarta | pparpathway | basic mechanism of action of ppara pparb(d) and pparg and effects on gene expression |
| biocarta | rarpathway | degradation of the rar and rxr by the proteasome |
| biocarta | rarrxrpathway | nuclear receptors coordinate the activities of chromatin remodeling complexes and coactivators to facilitate initiation of transcription in carcinoma cells |
| biocarta | vobesitypathway | visceral fat deposits and the metabolic syndrome |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-1368082 | RORA activates gene expression |
| reactome | R-HSA-1368108 | BMAL1:CLOCK,NPAS2 activates circadian gene expression |
| reactome | R-HSA-1428517 | The citric acid (TCA) cycle and respiratory electron transport |
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-1592230 | Mitochondrial biogenesis |
| reactome | R-HSA-159418 | Recycling of bile acids and salts |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-1655829 | Regulation of cholesterol biosynthesis by SREBP (SREBF) |
| reactome | R-HSA-1852241 | Organelle biogenesis and maintenance |
| reactome | R-HSA-192105 | Synthesis of bile acids and bile salts |
| reactome | R-HSA-193368 | Synthesis of bile acids and bile salts via 7alpha-hydroxycholesterol |
| reactome | R-HSA-193807 | Synthesis of bile acids and bile salts via 27-hydroxycholesterol |
| reactome | R-HSA-194068 | Bile acid and bile salt metabolism |
| reactome | R-HSA-1989781 | PPARA activates gene expression |
| reactome | R-HSA-1989781 | PPARA activates gene expression |
| reactome | R-HSA-200425 | Import of palmitoyl-CoA into the mitochondrial matrix |
| reactome | R-HSA-204174 | Regulation of pyruvate dehydrogenase (PDH) complex |
| reactome | R-HSA-211859 | Biological oxidations |
| reactome | R-HSA-211897 | Cytochrome P450 - arranged by substrate type |
| reactome | R-HSA-211945 | Phase I - Functionalization of compounds |
| reactome | R-HSA-211976 | Endogenous sterols |
| reactome | R-HSA-212436 | Generic Transcription Pathway |
| reactome | R-HSA-2151201 | Transcriptional activation of mitochondrial biogenesis |
| reactome | R-HSA-2426168 | Activation of gene expression by SREBF (SREBP) |
| reactome | R-HSA-2990846 | SUMOylation |
| reactome | R-HSA-3108232 | SUMO E3 ligases SUMOylate target proteins |
| reactome | R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation |
| reactome | R-HSA-381340 | Transcriptional regulation of white adipocyte differentiation |
| reactome | R-HSA-383280 | Nuclear Receptor transcription pathway |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-400206 | Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) |
| reactome | R-HSA-400206 | Regulation of lipid metabolism by Peroxisome proliferator-activated receptor alpha (PPARalpha) |
| reactome | R-HSA-400253 | Circadian Clock |
| reactome | R-HSA-400253 | Circadian Clock |
| reactome | R-HSA-4090294 | SUMOylation of intracellular receptors |
| reactome | R-HSA-5362517 | Signaling by Retinoic Acid |
| reactome | R-HSA-556833 | Metabolism of lipids |
| reactome | R-HSA-556833 | Metabolism of lipids |
| reactome | R-HSA-5617472 | Activation of anterior HOX genes in hindbrain development during early embryogenesis |
| reactome | R-HSA-5619507 | Activation of HOX genes during differentiation |
| reactome | R-HSA-597592 | Post-translational protein modification |
| reactome | R-HSA-70268 | Pyruvate metabolism |
| reactome | R-HSA-71406 | Pyruvate metabolism and Citric Acid (TCA) cycle |
| reactome | R-HSA-73857 | RNA Polymerase II Transcription |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| reactome | R-HSA-8957322 | Metabolism of steroids |
| reactome | R-HSA-8978868 | Fatty acid metabolism |
| reactome | R-HSA-9006931 | Signaling by Nuclear Receptors |
| wikipathways | WP1531 | Vitamin D Metabolism |
| wikipathways | WP1541 | Energy Metabolism |
| wikipathways | WP170 | Nuclear Receptors |
| wikipathways | WP236 | Adipogenesis |
| wikipathways | WP2874 | Liver X Receptor Pathway |
| wikipathways | WP2875 | Constitutive Androstane Receptor Pathway |
| wikipathways | WP2876 | Pregnane X Receptor pathway |
| wikipathways | WP2877 | Vitamin D Receptor Pathway |
| wikipathways | WP2878 | PPAR Alpha Pathway |
| wikipathways | WP2879 | Farnesoid X Receptor Pathway |
| wikipathways | WP2880 | Glucocorticoid Receptor Pathway |
| wikipathways | WP2882 | Nuclear Receptors Meta-Pathway |
| wikipathways | WP2884 | NRF2 pathway |
| wikipathways | WP3599 | Transcription factor regulation in adipogenesis |
| wikipathways | WP3915 | Angiopoietin Like Protein 8 Regulatory Pathway |
| wikipathways | WP3942 | PPAR signaling pathway |
| wikipathways | WP3995 | Prion disease pathway |
| wikipathways | WP4141 | PI3K-AKT-mTOR - VitD3 Signalling |
| wikipathways | WP716 | Vitamin A and Carotenoid Metabolism |
| pid | a6b1_a6b4_integrin_pathway | a6b1 and a6b4 Integrin signaling |
| pid | ar_tf_pathway | Regulation of Androgen receptor activity |
| pid | retinoic_acid_pathway | Retinoic acid receptors-mediated signaling |
| pid | rxr_vdr_pathway | RXR and RAR heterodimerization with other nuclear receptor |
| netpath | Pathway_TNFalpha | TNFalpha |
| kegg | hsa03320 | PPAR signaling pathway - Homo sapiens (human) |
| kegg | hsa04151 | PI3K-Akt signaling pathway - Homo sapiens (human) |
| kegg | hsa04659 | Th17 cell differentiation - Homo sapiens (human) |
| kegg | hsa04919 | Thyroid hormone signaling pathway - Homo sapiens (human) |
| kegg | hsa04920 | Adipocytokine signaling pathway - Homo sapiens (human) |
| kegg | hsa04932 | Non-alcoholic fatty liver disease (NAFLD) - Homo sapiens (human) |
| kegg | hsa04976 | Bile secretion - Homo sapiens (human) |
| kegg | hsa05160 | Hepatitis C - Homo sapiens (human) |
| kegg | hsa05200 | Pathways in cancer - Homo sapiens (human) |
| kegg | hsa05202 | Transcriptional misregulation in cancer - Homo sapiens (human) |
| kegg | hsa05216 | Thyroid cancer - Homo sapiens (human) |
| kegg | hsa05222 | Small cell lung cancer - Homo sapiens (human) |
| kegg | hsa05223 | Non-small cell lung cancer - Homo sapiens (human) |
| kegg | hsa05226 | Gastric cancer - Homo sapiens (human) |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD345 | Compound 10b [PMID: 11504634] | 4 |
| iGMDRD150 | RITA | 3 |
| iGMDRD512 | nutlin 3 | 4 |
| iGMDRD177 | Teniposide | 2 |
| iGMDRD351 | GW843682X | 4 |
| iGMDRD267 | Oligomycin A | 1 |
| iGMDRD415 | LE-135 | 2 |
| iGMDRD705 | Nakiterpiosin | 3 |
| iGMDRD121 | GMX1778 | 1 |
| iGMDRD137 | Indisulam | 2 |
| iGMDRD103 | SN-38 | 3 |
| iGMDRD353 | PD0325901 | 4 |
| iGMDRD781 | Sirolimus | 4 |
| iGMDRD494 | Neopeltolide | 4 |
| iGMDRD772 | BRD4770 | 2 |
| iGMDRD420 | Leucascandrolide A | 2 |
| iGMDRD126 | Tipifarnib | 3 |
| iGMDRD634 | SCHEMBL2608041 | 4 |
| iGMDRD375 | GW-405833 | 2 |
| iGMDRD280 | CYTOCHALASIN B | 3 |
| iGMDRD466 | Chaetocin | 2 |
| iGMDRD679 | Bistramide A | 6 |
| iGMDRD297 | Austocystin D | 3 |
| iGMDRD152 | 179324-69-7 | 3 |
| iGMDRD801 | 2,4-dideoxy-DC-45-A2 | 3 |
| iGMDRD782 | DC-45-A2 | 2 |
| iGMDRD171 | Pemetrexed | 3 |
| iGMDRD451 | Serdemetan | 3 |
| iGMDRD369 | TGX-115 | 3 |
| iGMDRD577 | BIX01294 | 4 |
| iGMDRD188 | Piperlongumine | 1 |
| iGMDRD100 | Zebularine | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in RXRA
CLASSFICATION
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