FGFR4


Summary: The protein encoded by this gene is a tyrosine kinase and cell surface receptor for fibroblast growth factors. The encoded protein is involved in the regulation of several pathways, including cell proliferation, cell differentiation, cell migration, lipid metabolism, bile acid biosynthesis, vitamin D metabolism, glucose uptake, and phosphate homeostasis. This protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment, and a cytoplasmic tyrosine kinase domain. The extracellular portion interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. [provided by RefSeq, Aug 2017].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
fibroblast growth factor receptor 4MIM:134935Ensembl:ENSG00000160867HGNC:HGNC:3691PA281305q35.2

GO terms in FGFR4


Term TypeEvidence TypeGO Term IDGO Des.
MFIBAGO:0004709MAP kinase kinase kinase activity
MFIBAGO:0004713protein tyrosine kinase activity
MFTASGO:0004713protein tyrosine kinase activity
MFIBAGO:0004714transmembrane receptor protein tyrosine kinase activity
MFIBAGO:0004888transmembrane signaling receptor activity
MFIBAGO:0005007fibroblast growth factor-activated receptor activity
MFIDAGO:0005007fibroblast growth factor-activated receptor activity
MFIGIGO:0005007fibroblast growth factor-activated receptor activity
MFTASGO:0005088Ras guanyl-nucleotide exchange factor activity
MFIPIGO:0005515protein binding
MFIEAGO:0005524ATP binding
MFIDAGO:0008201heparin binding
MFTASGO:00163031-phosphatidylinositol-3-kinase activity
MFIBAGO:0017134fibroblast growth factor binding
MFIDAGO:0017134fibroblast growth factor binding
MFIPIGO:0017134fibroblast growth factor binding
MFIBAGO:0031434mitogen-activated protein kinase kinase binding
MFTASGO:0046934phosphatidylinositol-4,5-bisphosphate 3-kinase activity
BPTASGO:0000165MAPK cascade
BPIBAGO:0001525angiogenesis
BPIBAGO:0007275multicellular organism development
BPIBAGO:0007417central nervous system development
BPIBAGO:0008284positive regulation of cell proliferation
BPIDAGO:0008284positive regulation of cell proliferation
BPIGIGO:0008284positive regulation of cell proliferation
BPIDAGO:0008543fibroblast growth factor receptor signaling pathway
BPIGIGO:0008543fibroblast growth factor receptor signaling pathway
BPIPIGO:0008543fibroblast growth factor receptor signaling pathway
BPTASGO:0008543fibroblast growth factor receptor signaling pathway
BPIBAGO:0009968negative regulation of signal transduction
BPIMPGO:0010628positive regulation of gene expression
BPIMPGO:0010715regulation of extracellular matrix disassembly
BPIMPGO:0016477cell migration
BPIDAGO:0018108peptidyl-tyrosine phosphorylation
BPISSGO:0019216regulation of lipid metabolic process
BPIBAGO:0030154cell differentiation
BPIBAGO:0033674positive regulation of kinase activity
BPIEAGO:0036092phosphatidylinositol-3-phosphate biosynthetic process
BPISSGO:0042593glucose homeostasis
BPISSGO:0042632cholesterol homeostasis
BPIBAGO:0043066negative regulation of apoptotic process
BPIMPGO:0043085positive regulation of catalytic activity
BPIBAGO:0043410positive regulation of MAPK cascade
BPIMPGO:0045862positive regulation of proteolysis
BPIDAGO:0046777protein autophosphorylation
BPIEAGO:0046854phosphatidylinositol phosphorylation
BPTASGO:0051897positive regulation of protein kinase B signaling
BPISSGO:0055062phosphate ion homeostasis
BPIBAGO:0070374positive regulation of ERK1 and ERK2 cascade
BPIMPGO:0070374positive regulation of ERK1 and ERK2 cascade
BPIMPGO:0070857regulation of bile acid biosynthetic process
BPIMPGO:1903412response to bile acid
BPIMPGO:2000573positive regulation of DNA biosynthetic process
CCIEAGO:0005576extracellular region
CCIBAGO:0005737cytoplasm
CCIEAGO:0005768endosome
CCIDAGO:0005783endoplasmic reticulum
CCIDAGO:0005794Golgi apparatus
CCIDAGO:0005886plasma membrane
CCTASGO:0005886plasma membrane
CCIBAGO:0005887integral component of plasma membrane
CCIDAGO:0005887integral component of plasma membrane
CCIDAGO:0005911cell-cell junction
CCIDAGO:0030133transport vesicle
CCIBAGO:0043235receptor complex

Gene expression in normal tissue: FGFR4

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in FGFR4


DatabasePathway IDPathway Des.
reactomeR-HSA-109704PI3K Cascade
reactomeR-HSA-112399IRS-mediated signalling
reactomeR-HSA-1226099Signaling by FGFR in disease
reactomeR-HSA-1257604PIP3 activates AKT signaling
reactomeR-HSA-1307965betaKlotho-mediated ligand binding
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-1643685Disease
reactomeR-HSA-1839128FGFR4 mutant receptor activation
reactomeR-HSA-190236Signaling by FGFR
reactomeR-HSA-190322FGFR4 ligand binding and activation
reactomeR-HSA-199418Negative regulation of the PI3K/AKT network
reactomeR-HSA-2219528PI3K/AKT Signaling in Cancer
reactomeR-HSA-2219530Constitutive Signaling by Aberrant PI3K in Cancer
reactomeR-HSA-2404192Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
reactomeR-HSA-2428924IGF1R signaling cascade
reactomeR-HSA-2428928IRS-related events triggered by IGF1R
reactomeR-HSA-5654228Phospholipase C-mediated cascade; FGFR4
reactomeR-HSA-5654712FRS-mediated FGFR4 signaling
reactomeR-HSA-5654716Downstream signaling of activated FGFR4
reactomeR-HSA-5654719SHC-mediated cascade:FGFR4
reactomeR-HSA-5654720PI-3K cascade:FGFR4
reactomeR-HSA-5654733Negative regulation of FGFR4 signaling
reactomeR-HSA-5654743Signaling by FGFR4
reactomeR-HSA-5655291Signaling by FGFR4 in disease
reactomeR-HSA-5663202Diseases of signal transduction
reactomeR-HSA-5673001RAF/MAP kinase cascade
reactomeR-HSA-5683057MAPK family signaling cascades
reactomeR-HSA-5684996MAPK1/MAPK3 signaling
reactomeR-HSA-6811558PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
reactomeR-HSA-74751Insulin receptor signalling cascade
reactomeR-HSA-74752Signaling by Insulin receptor
reactomeR-HSA-9006925Intracellular signaling by second messengers
reactomeR-HSA-9006934Signaling by Receptor Tyrosine Kinases
pidfgf_pathwayFGF signaling pathway
pidsyndecan_1_pathwaySyndecan-1-mediated signaling events
pidsyndecan_2_pathwaySyndecan-2-mediated signaling events
pidsyndecan_3_pathwaySyndecan-3-mediated signaling events
kegghsa04010MAPK signaling pathway - Homo sapiens (human)
kegghsa04014Ras signaling pathway - Homo sapiens (human)
kegghsa04015Rap1 signaling pathway - Homo sapiens (human)
kegghsa04144Endocytosis - Homo sapiens (human)
kegghsa04151PI3K-Akt signaling pathway - Homo sapiens (human)
kegghsa04550Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human)
kegghsa04810Regulation of actin cytoskeleton - Homo sapiens (human)
kegghsa05200Pathways in cancer - Homo sapiens (human)
pharmgkbPA165980050Vemurafenib Pathway, Pharmacodynamics
pharmgkbPA165980050update your name in edit mode
pharmgkbPA2032VEGF Signaling Pathway
netpathPathway_Fibroblast__growth__factor-1Fibroblast growth factor-1
wikipathwaysWP3651Pathways Affected in Adenoid Cystic Carcinoma
wikipathwaysWP382MAPK Signaling Pathway
wikipathwaysWP3931ESC Pluripotency Pathways
wikipathwaysWP3932Focal Adhesion-PI3K-Akt-mTOR-signaling pathway
wikipathwaysWP4172PI3K-Akt Signaling Pathway
wikipathwaysWP4223Ras Signaling
wikipathwaysWP51Regulation of Actin Cytoskeleton

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD322FK 8662
iGMDRD451Serdemetan4
iGMDRD329Merck607
iGMDRD871BRD63683
iGMDRD887Compound 23 citrate2
iGMDRD911FGFR inhibitor8
iGMDRD872BRD71373
iGMDRD74Idarubicin3
iGMDRD8012,4-dideoxy-DC-45-A22
iGMDRD187BRD98761
iGMDRD294Batimastat2
iGMDRD289Parthenolide1
iGMDRD171Pemetrexed3
iGMDRD137Indisulam2
iGMDRD158NSC1415407
iGMDRD375GW-4058332
iGMDRD154NSC237664
iGMDRD945ML2142
iGMDRD394BX-7953
iGMDRD280CYTOCHALASIN B2
iGMDRD314Tanespimycin3
iGMDRD405PIK-752
iGMDRD427ABT7372
iGMDRD345Compound 10b [PMID: 11504634]1
iGMDRD512nutlin 37
iGMDRD599Salermide3

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in FGFR4

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