FGFR4

Summary: The protein encoded by this gene is a tyrosine kinase and cell surface receptor for fibroblast growth factors. The encoded protein is involved in the regulation of several pathways, including cell proliferation, cell differentiation, cell migration, lipid metabolism, bile acid biosynthesis, vitamin D metabolism, glucose uptake, and phosphate homeostasis. This protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment, and a cytoplasmic tyrosine kinase domain. The extracellular portion interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. [provided by RefSeq, Aug 2017].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Namefibroblast growth factor receptor 4
OMIM IDMIM:134935
Ensembl IDEnsembl:ENSG00000160867
HGNC IDHGNC:HGNC:3691
PHARMGKB IDPA28130
Map Location5q35.2

GO terms in FGFR4


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Term Type
Evidence Type
GO Term ID
GO Des.
MF IBA GO:0004709 MAP kinase kinase kinase activity
MF IBA GO:0004713 protein tyrosine kinase activity
MF TAS GO:0004713 protein tyrosine kinase activity
MF IBA GO:0004714 transmembrane receptor protein tyrosine kinase activity
MF IBA GO:0004888 transmembrane signaling receptor activity
MF IBA GO:0005007 fibroblast growth factor-activated receptor activity
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Gene expression in normal tissue: FGFR4

Gene-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 43BOWEtissue: BOWE cancer: BOWEL model num: 0BOWELtissue: BOWEL cancer: undefined model num: 15LUNtissue: LUN cancer: LUNG model num: 0LUNGtissue: LUNG cancer: undefined model num: 9UTERUtissue: UTERU cancer: UTERUS model num: 0UTERUStissue: UTERUS cancer: Endometrial Carcinoma (UCEC) model num: 6SOFT_TISSUtissue: SOFT_TISSU cancer: SOFT_TISSUE model num: 0SOFT_TISSUEtissue: SOFT_TISSUE cancer: Rhabdomyosarcoma (RMS) model num: 8

Gene-drug pathway distribution

undefined19DNA replication1Protein stability and degradation1One carbon pool by folate1Leukocyte transendothelial migration1p53 pathway1Metabolism1Chromatin histone acetylation1

Pathways in FGFR4


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Database
Pathway ID
Pathway Des.
reactome R-HSA-109704 PI3K Cascade
reactome R-HSA-112399 IRS-mediated signalling
reactome R-HSA-1226099 Signaling by FGFR in disease
reactome R-HSA-1257604 PIP3 activates AKT signaling
reactome R-HSA-1307965 betaKlotho-mediated ligand binding
reactome R-HSA-162582 Signal Transduction
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD322 FK 866 2
iGMDRD451 Serdemetan 4
iGMDRD329 Merck60 7
iGMDRD871 BRD6368 3
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in FGFR4

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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