GPC3
Summary: Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation. The protein encoded by this gene can bind to and inhibit the dipeptidyl peptidase activity of CD26, and it can induce apoptosis in certain cell types. Deletion mutations in this gene are associated with Simpson-Golabi-Behmel syndrome, also known as Simpson dysmorphia syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2009].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| glypican 3 | MIM:300037 | Ensembl:ENSG00000147257 | HGNC:HGNC:4451 | PA28832 | Xq26.2 |
GO terms in GPC3
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | TAS | GO:0001523 | retinoid metabolic process |
| BP | IEA | GO:0001658 | branching involved in ureteric bud morphogenesis |
| BP | TAS | GO:0006024 | glycosaminoglycan biosynthetic process |
| BP | TAS | GO:0006027 | glycosaminoglycan catabolic process |
| BP | TAS | GO:0009653 | anatomical structure morphogenesis |
| BP | IEA | GO:0009948 | anterior/posterior axis specification |
| BP | IEA | GO:0010171 | body morphogenesis |
| BP | IEA | GO:0010466 | negative regulation of peptidase activity |
| BP | IEA | GO:0030282 | bone mineralization |
| BP | IEA | GO:0030316 | osteoclast differentiation |
| BP | IEA | GO:0030324 | lung development |
| BP | IEA | GO:0030513 | positive regulation of BMP signaling pathway |
| BP | IEA | GO:0035116 | embryonic hindlimb morphogenesis |
| BP | TAS | GO:0043687 | post-translational protein modification |
| BP | TAS | GO:0044267 | cellular protein metabolic process |
| BP | IEA | GO:0045732 | positive regulation of protein catabolic process |
| BP | IEA | GO:0045807 | positive regulation of endocytosis |
| BP | IEA | GO:0045879 | negative regulation of smoothened signaling pathway |
| BP | IEA | GO:0045880 | positive regulation of smoothened signaling pathway |
| BP | IEA | GO:0045926 | negative regulation of growth |
| BP | IEA | GO:0046326 | positive regulation of glucose import |
| BP | IEA | GO:0050680 | negative regulation of epithelial cell proliferation |
| BP | IEA | GO:0060976 | coronary vasculature development |
| BP | ISS | GO:0072138 | mesenchymal cell proliferation involved in ureteric bud development |
| BP | IEA | GO:0072180 | mesonephric duct morphogenesis |
| BP | IEA | GO:0072203 | cell proliferation involved in metanephros development |
| BP | IEA | GO:0090090 | negative regulation of canonical Wnt signaling pathway |
| BP | IEA | GO:2000096 | positive regulation of Wnt signaling pathway, planar cell polarity pathway |
| CC | IEA | GO:0005615 | extracellular space |
| CC | TAS | GO:0005788 | endoplasmic reticulum lumen |
| CC | TAS | GO:0005796 | Golgi lumen |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | TAS | GO:0031226 | intrinsic component of plasma membrane |
| CC | TAS | GO:0043202 | lysosomal lumen |
| CC | IEA | GO:0046658 | anchored component of plasma membrane |
| CC | IEA | GO:0062023 | collagen-containing extracellular matrix |
| MF | IPI | GO:0005515 | protein binding |
| MF | IDA | GO:0060422 | peptidyl-dipeptidase inhibitor activity |
Gene expression in normal tissue: GPC3
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in GPC3
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| pid | glypican_3pathway | Glypican 3 network |
| kegg | hsa05205 | Proteoglycans in cancer - Homo sapiens (human) |
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-1630316 | Glycosaminoglycan metabolism |
| reactome | R-HSA-1630316 | Glycosaminoglycan metabolism |
| reactome | R-HSA-1638091 | Heparan sulfate/heparin (HS-GAG) metabolism |
| reactome | R-HSA-1638091 | Heparan sulfate/heparin (HS-GAG) metabolism |
| reactome | R-HSA-1643685 | Disease |
| reactome | R-HSA-1793185 | Chondroitin sulfate/dermatan sulfate metabolism |
| reactome | R-HSA-196854 | Metabolism of vitamins and cofactors |
| reactome | R-HSA-1971475 | A tetrasaccharide linker sequence is required for GAG synthesis |
| reactome | R-HSA-2022928 | HS-GAG biosynthesis |
| reactome | R-HSA-2022928 | HS-GAG biosynthesis |
| reactome | R-HSA-2024096 | HS-GAG degradation |
| reactome | R-HSA-2187338 | Visual phototransduction |
| reactome | R-HSA-3560782 | Diseases associated with glycosaminoglycan metabolism |
| reactome | R-HSA-3560783 | Defective B4GALT7 causes EDS, progeroid type |
| reactome | R-HSA-3560801 | Defective B3GAT3 causes JDSSDHD |
| reactome | R-HSA-3656237 | Defective EXT2 causes exostoses 2 |
| reactome | R-HSA-3656253 | Defective EXT1 causes exostoses 1, TRPS2 and CHDS |
| reactome | R-HSA-372790 | Signaling by GPCR |
| reactome | R-HSA-3781865 | Diseases of glycosylation |
| reactome | R-HSA-381426 | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) |
| reactome | R-HSA-388396 | GPCR downstream signalling |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-418594 | G alpha (i) signalling events |
| reactome | R-HSA-4420332 | Defective B3GALT6 causes EDSP2 and SEMDJL1 |
| reactome | R-HSA-597592 | Post-translational protein modification |
| reactome | R-HSA-6806667 | Metabolism of fat-soluble vitamins |
| reactome | R-HSA-71387 | Metabolism of carbohydrates |
| reactome | R-HSA-71387 | Metabolism of carbohydrates |
| reactome | R-HSA-8957275 | Post-translational protein phosphorylation |
| reactome | R-HSA-975634 | Retinoid metabolism and transport |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD366 | PI-103 | 1 |
| iGMDRD882 | CIL41 | 3 |
| iGMDRD524 | ISX-9 | 3 |
| iGMDRD246 | NPC26 | 5 |
| iGMDRD211 | (1S,3R)-RSL3 | 2 |
| iGMDRD1008 | SR-II-138A | 3 |
| iGMDRD425 | ERASTIN | 2 |
| iGMDRD158 | NSC141540 | 2 |
| iGMDRD84 | Lovastatin acid | 1 |
| iGMDRD513 | BML-259 | 3 |
| iGMDRD481 | Dactolisib | 3 |
| iGMDRD345 | Compound 10b [PMID: 11504634] | 2 |
| iGMDRD670 | ML 210 | 1 |
| iGMDRD192 | CIL56 | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in GPC3
CLASSFICATION
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