GPC3
Summary: Cell surface heparan sulfate proteoglycans are composed of a membrane-associated protein core substituted with a variable number of heparan sulfate chains. Members of the glypican-related integral membrane proteoglycan family (GRIPS) contain a core protein anchored to the cytoplasmic membrane via a glycosyl phosphatidylinositol linkage. These proteins may play a role in the control of cell division and growth regulation. The protein encoded by this gene can bind to and inhibit the dipeptidyl peptidase activity of CD26, and it can induce apoptosis in certain cell types. Deletion mutations in this gene are associated with Simpson-Golabi-Behmel syndrome, also known as Simpson dysmorphia syndrome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2009].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
Nameglypican 3 OMIM IDMIM:300037 Ensembl IDEnsembl:ENSG00000147257 HGNC IDHGNC:HGNC:4451 PHARMGKB IDPA28832 Map LocationXq26.2 | |||||
GO terms in GPC3
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | TAS | GO:0001523 | retinoid metabolic process |
| BP | IEA | GO:0001658 | branching involved in ureteric bud morphogenesis |
| BP | TAS | GO:0006024 | glycosaminoglycan biosynthetic process |
| BP | TAS | GO:0006027 | glycosaminoglycan catabolic process |
| BP | TAS | GO:0009653 | anatomical structure morphogenesis |
| BP | IEA | GO:0009948 | anterior/posterior axis specification |
Gene expression in normal tissue: GPC3
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in GPC3
Database | Pathway ID | Pathway Des. |
|---|---|---|
| pid | glypican_3pathway | Glypican 3 network |
| kegg | hsa05205 | Proteoglycans in cancer - Homo sapiens (human) |
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-1630316 | Glycosaminoglycan metabolism |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in GPC3
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
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