PDE4DIP
Summary: The protein encoded by this gene serves to anchor phosphodiesterase 4D to the Golgi/centrosome region of the cell. Defects in this gene may be a cause of myeloproliferative disorder (MBD) associated with eosinophilia. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2010].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| phosphodiesterase 4D interacting protein | MIM:608117 | Ensembl:ENSG00000178104 | HGNC:HGNC:15580 | PA33131 | 1q21.2 |
GO terms in PDE4DIP
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005794 | Golgi apparatus |
| CC | ISS | GO:0005794 | Golgi apparatus |
| CC | IDA | GO:0005813 | centrosome |
| CC | ISS | GO:0005813 | centrosome |
| CC | ISS | GO:0030016 | myofibril |
| BP | ISS | GO:0034622 | cellular protein-containing complex assembly |
| BP | IDA | GO:1903358 | regulation of Golgi organization |
| MF | IPI | GO:0005515 | protein binding |
| MF | ISS | GO:0019899 | enzyme binding |
| MF | IDA | GO:0032947 | protein-containing complex scaffold activity |
Gene expression in normal tissue: PDE4DIP
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PDE4DIP
| Database | Pathway ID | Pathway Des. |
|---|
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD871 | BRD6368 | 1 |
| iGMDRD286 | Nsc 632839 | 8 |
| iGMDRD329 | Merck60 | 8 |
| iGMDRD662 | JQ-1 | 3 |
| iGMDRD552 | AZD-1775 | 4 |
| iGMDRD103 | SN-38 | 6 |
| iGMDRD137 | Indisulam | 4 |
| iGMDRD158 | NSC141540 | 2 |
| iGMDRD5 | Tyrphostin AG 1478 | 2 |
| iGMDRD105 | Triptolide | 5 |
| iGMDRD705 | Nakiterpiosin | 2 |
| iGMDRD341 | Triacsin c | 3 |
| iGMDRD237 | ABT-751 | 2 |
| iGMDRD123 | Isoevodiamine | 3 |
| iGMDRD150 | RITA | 3 |
| iGMDRD523 | Cyanoquinoline, 11 | 1 |
| iGMDRD79 | Gemcitabine | 1 |
| iGMDRD188 | Piperlongumine | 2 |
| iGMDRD399 | Selumetinib | 1 |
| iGMDRD74 | Idarubicin | 2 |
| iGMDRD64 | Parbendazole | 6 |
| iGMDRD356 | PNU-74654 | 3 |
| iGMDRD524 | ISX-9 | 2 |
| iGMDRD260 | FQI-2 | 6 |
| iGMDRD294 | Batimastat | 1 |
| iGMDRD639 | YK 4-279 | 1 |
| iGMDRD61 | Kinetin riboside | 3 |
| iGMDRD2 | PK-11195 | 3 |
| iGMDRD679 | Bistramide A | 1 |
| iGMDRD466 | Chaetocin | 2 |
| iGMDRD76 | Simvastatin | 3 |
| iGMDRD126 | Tipifarnib | 2 |
| iGMDRD433 | Lexibulin | 5 |
| iGMDRD151 | CHM-1 | 6 |
| iGMDRD889 | Compound 7d-cis | 1 |
| iGMDRD420 | Leucascandrolide A | 5 |
| iGMDRD427 | ABT737 | 2 |
| iGMDRD670 | ML 210 | 3 |
| iGMDRD779 | PRL-3 Inhibitor I | 3 |
| iGMDRD484 | Pluripotin | 3 |
| iGMDRD781 | Sirolimus | 2 |
| iGMDRD872 | BRD7137 | 3 |
| iGMDRD300 | Tozasertib | 2 |
| iGMDRD505 | Pevonedistat | 3 |
| iGMDRD246 | NPC26 | 3 |
| iGMDRD42 | Vorinostat | 3 |
| iGMDRD192 | CIL56 | 2 |
| iGMDRD231 | Importazole | 3 |
| iGMDRD85 | Ursolic acid | 2 |
| iGMDRD351 | GW843682X | 2 |
| iGMDRD512 | nutlin 3 | 5 |
| iGMDRD116 | CD437 | 3 |
| iGMDRD345 | Compound 10b [PMID: 11504634] | 6 |
| iGMDRD100 | Zebularine | 2 |
| iGMDRD887 | Compound 23 citrate | 3 |
| iGMDRD398 | Sepantronium | 2 |
| iGMDRD562 | Navitoclax | 8 |
| iGMDRD60 | Quinoclamine | 5 |
| iGMDRD480 | KU0060648 | 4 |
| iGMDRD138 | PX 12 | 6 |
| iGMDRD255 | SB225002 | 2 |
| iGMDRD318 | PAC-1 | 1 |
| iGMDRD446 | LY 2183240 | 3 |
| iGMDRD193 | Fqi1 | 5 |
| iGMDRD280 | CYTOCHALASIN B | 4 |
| iGMDRD634 | SCHEMBL2608041 | 3 |
| iGMDRD387 | CHIR-99021 | 2 |
| iGMDRD1008 | SR-II-138A | 3 |
| iGMDRD144 | NSC95397 | 3 |
| iGMDRD494 | Neopeltolide | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PDE4DIP
CLASSFICATION
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