TLE1
Summary:
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| transducin like enhancer of split 1 | MIM:600189 | Ensembl:ENSG00000196781 | HGNC:HGNC:11837 | PA36539 | 9q21.32 |
Gene Categories:
TRANSCRIPTION FACTOR BINDINGGO terms in TLE1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IBA | GO:0005634 | nucleus |
| CC | IDA | GO:0005634 | nucleus |
| CC | IMP | GO:0005634 | nucleus |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IBA | GO:0005667 | transcription factor complex |
| CC | IMP | GO:0005829 | cytosol |
| CC | IDA | GO:1990907 | beta-catenin-TCF complex |
| BP | IEA | GO:0006351 | transcription, DNA-templated |
| BP | TAS | GO:0007165 | signal transduction |
| BP | TAS | GO:0007275 | multicellular organism development |
| BP | TAS | GO:0009887 | animal organ morphogenesis |
| BP | IMP | GO:0010628 | positive regulation of gene expression |
| BP | IEA | GO:0016055 | Wnt signaling pathway |
| BP | NAS | GO:0030178 | negative regulation of Wnt signaling pathway |
| BP | IDA | GO:0043124 | negative regulation of I-kappaB kinase/NF-kappaB signaling |
| BP | IDA | GO:0045892 | negative regulation of transcription, DNA-templated |
| BP | IBA | GO:0090090 | negative regulation of canonical Wnt signaling pathway |
| BP | TAS | GO:1904837 | beta-catenin-TCF complex assembly |
| BP | IMP | GO:2000811 | negative regulation of anoikis |
| MF | IBA | GO:0003714 | transcription corepressor activity |
| MF | IDA | GO:0003714 | transcription corepressor activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IDA | GO:0008134 | transcription factor binding |
| MF | IPI | GO:0008134 | transcription factor binding |
| MF | IPI | GO:0042802 | identical protein binding |
| MF | IBA | GO:0070491 | repressing transcription factor binding |
Gene expression in normal tissue: TLE1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in TLE1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-157118 | Signaling by NOTCH |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-195253 | Degradation of beta-catenin by the destruction complex |
| reactome | R-HSA-195253 | Degradation of beta-catenin by the destruction complex |
| reactome | R-HSA-195721 | Signaling by WNT |
| reactome | R-HSA-195721 | Signaling by WNT |
| reactome | R-HSA-1980143 | Signaling by NOTCH1 |
| reactome | R-HSA-201681 | TCF dependent signaling in response to WNT |
| reactome | R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex |
| reactome | R-HSA-2122947 | NOTCH1 Intracellular Domain Regulates Transcription |
| reactome | R-HSA-3769402 | Deactivation of the beta-catenin transactivating complex |
| reactome | R-HSA-4641265 | Repression of WNT target genes |
| reactome | R-HSA-4641265 | Repression of WNT target genes |
| biocarta | wntpathway | wnt signaling pathway |
| pid | betacatenin_nuc_pathway | Regulation of nuclear beta catenin signaling and target gene transcription |
| pid | hes_heypathway | Notch-mediated HES/HEY network |
| pid | ps1pathway | Presenilin action in Notch and Wnt signaling |
| wikipathways | WP61 | Notch Signaling Pathway |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD494 | Neopeltolide | 2 |
| iGMDRD523 | Cyanoquinoline, 11 | 2 |
| iGMDRD405 | PIK-75 | 3 |
| iGMDRD345 | Compound 10b [PMID: 11504634] | 2 |
| iGMDRD889 | Compound 7d-cis | 3 |
| iGMDRD584 | VER 155008 | 3 |
| iGMDRD420 | Leucascandrolide A | 2 |
| iGMDRD772 | BRD4770 | 2 |
| iGMDRD330 | BRD4132 | 2 |
| iGMDRD634 | SCHEMBL2608041 | 2 |
| iGMDRD945 | ML214 | 1 |
| iGMDRD132 | (-)-gallocatechin-3-O-gallate | 2 |
| iGMDRD297 | Austocystin D | 3 |
| iGMDRD901 | ELCPK | 2 |
| iGMDRD466 | Chaetocin | 2 |
| iGMDRD123 | Isoevodiamine | 1 |
| iGMDRD61 | Kinetin riboside | 3 |
| iGMDRD52 | Rotenone | 2 |
| iGMDRD213 | SMR000068650 | 3 |
| iGMDRD434 | BMS-536924 | 6 |
| iGMDRD255 | SB225002 | 2 |
| iGMDRD137 | Indisulam | 3 |
| iGMDRD23 | Gossypol | 2 |
| iGMDRD64 | Parbendazole | 5 |
| iGMDRD60 | Quinoclamine | 4 |
| iGMDRD506 | Fedratinib | 2 |
| iGMDRD888 | Compound 44 | 7 |
| iGMDRD188 | Piperlongumine | 2 |
| iGMDRD286 | Nsc 632839 | 5 |
| iGMDRD74 | Idarubicin | 2 |
| iGMDRD872 | BRD7137 | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in TLE1
CLASSFICATION
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