MRE11
Summary: This gene encodes a nuclear protein involved in homologous recombination, telomere length maintenance, and DNA double-strand break repair. By itself, the protein has 3' to 5' exonuclease activity and endonuclease activity. The protein forms a complex with the RAD50 homolog; this complex is required for nonhomologous joining of DNA ends and possesses increased single-stranded DNA endonuclease and 3' to 5' exonuclease activities. In conjunction with a DNA ligase, this protein promotes the joining of noncomplementary ends in vitro using short homologies near the ends of the DNA fragments. This gene has a pseudogene on chromosome 3. Alternative splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| MRE11 homolog, double strand break repair nuclease | MIM:600814 | Ensembl:ENSG00000020922 | HGNC:HGNC:7230 | PA30934 | 11q21 |
GO terms in MRE11
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IDA | GO:0000781 | chromosome, telomeric region |
| CC | HDA | GO:0000784 | nuclear chromosome, telomeric region |
| CC | IBA | GO:0000784 | nuclear chromosome, telomeric region |
| CC | IDA | GO:0000784 | nuclear chromosome, telomeric region |
| CC | IDA | GO:0000784 | nuclear chromosome, telomeric region |
| CC | ISS | GO:0000784 | nuclear chromosome, telomeric region |
| CC | IBA | GO:0000785 | chromatin |
| CC | TAS | GO:0005634 | nucleus |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | TAS | GO:0005829 | cytosol |
| CC | IDA | GO:0016605 | PML body |
| CC | ISS | GO:0016605 | PML body |
| CC | IBA | GO:0030870 | Mre11 complex |
| CC | IDA | GO:0030870 | Mre11 complex |
| CC | NAS | GO:0030870 | Mre11 complex |
| CC | TAS | GO:0030870 | Mre11 complex |
| CC | IBA | GO:0035861 | site of double-strand break |
| CC | IDA | GO:0035861 | site of double-strand break |
| BP | TAS | GO:0000019 | regulation of mitotic recombination |
| BP | IBA | GO:0000723 | telomere maintenance |
| BP | TAS | GO:0000724 | double-strand break repair via homologous recombination |
| BP | TAS | GO:0000729 | DNA double-strand break processing |
| BP | TAS | GO:0006260 | DNA replication |
| BP | TAS | GO:0006281 | DNA repair |
| BP | IBA | GO:0006284 | base-excision repair |
| BP | IBA | GO:0006302 | double-strand break repair |
| BP | TAS | GO:0006302 | double-strand break repair |
| BP | IDA | GO:0006303 | double-strand break repair via nonhomologous end joining |
| BP | TAS | GO:0006303 | double-strand break repair via nonhomologous end joining |
| BP | TAS | GO:0006310 | DNA recombination |
| BP | IDA | GO:0006974 | cellular response to DNA damage stimulus |
| BP | TAS | GO:0007004 | telomere maintenance via telomerase |
| BP | IBA | GO:0007062 | sister chromatid cohesion |
| BP | IMP | GO:0007062 | sister chromatid cohesion |
| BP | IBA | GO:0007095 | mitotic G2 DNA damage checkpoint |
| BP | IEA | GO:0007095 | mitotic G2 DNA damage checkpoint |
| BP | IEA | GO:0007129 | synapsis |
| BP | TAS | GO:0007131 | reciprocal meiotic recombination |
| BP | IEA | GO:0008283 | cell proliferation |
| BP | IEA | GO:0016032 | viral process |
| BP | IBA | GO:0031573 | intra-S DNA damage checkpoint |
| BP | IBA | GO:0031860 | telomeric 3' overhang formation |
| BP | IMP | GO:0031860 | telomeric 3' overhang formation |
| BP | IDA | GO:0031954 | positive regulation of protein autophosphorylation |
| BP | IMP | GO:0032206 | positive regulation of telomere maintenance |
| BP | TAS | GO:0032481 | positive regulation of type I interferon production |
| BP | IMP | GO:0032508 | DNA duplex unwinding |
| BP | IMP | GO:0032876 | negative regulation of DNA endoreduplication |
| BP | IDA | GO:0033674 | positive regulation of kinase activity |
| BP | IBA | GO:0042138 | meiotic DNA double-strand break formation |
| BP | IMP | GO:0043066 | negative regulation of apoptotic process |
| BP | IEA | GO:0090305 | nucleic acid phosphodiester bond hydrolysis |
| BP | IBA | GO:0097552 | mitochondrial double-strand break repair via homologous recombination |
| MF | IBA | GO:0000014 | single-stranded DNA endodeoxyribonuclease activity |
| MF | IDA | GO:0000014 | single-stranded DNA endodeoxyribonuclease activity |
| MF | IDA | GO:0003677 | DNA binding |
| MF | TAS | GO:0003690 | double-stranded DNA binding |
| MF | IBA | GO:0003691 | double-stranded telomeric DNA binding |
| MF | IMP | GO:0004003 | ATP-dependent DNA helicase activity |
| MF | TAS | GO:0004518 | nuclease activity |
| MF | IBA | GO:0004519 | endonuclease activity |
| MF | IDA | GO:0004520 | endodeoxyribonuclease activity |
| MF | TAS | GO:0004520 | endodeoxyribonuclease activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IPI | GO:0008022 | protein C-terminus binding |
| MF | IBA | GO:0008408 | 3'-5' exonuclease activity |
| MF | IDA | GO:0008408 | 3'-5' exonuclease activity |
| MF | IBA | GO:0030145 | manganese ion binding |
| MF | IEA | GO:0030145 | manganese ion binding |
| MF | IPI | GO:0042802 | identical protein binding |
| MF | IBA | GO:0043047 | single-stranded telomeric DNA binding |
| MF | HDA | GO:0045296 | cadherin binding |
Gene expression in normal tissue: MRE11
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in MRE11
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| pid | atm_pathway | ATM pathway |
| pid | bard1pathway | BARD1 signaling events |
| pid | deltanp63pathway | Validated transcriptional targets of deltaNp63 isoforms |
| pid | fanconi_pathway | Fanconi anemia pathway |
| pid | telomerasepathway | Regulation of Telomerase |
| kegg | hsa03440 | Homologous recombination - Homo sapiens (human) |
| kegg | hsa03450 | Non-homologous end-joining - Homo sapiens (human) |
| kegg | hsa04218 | Cellular senescence - Homo sapiens (human) |
| wikipathways | WP1530 | miRNA Regulation of DNA Damage Response |
| wikipathways | WP186 | Homologous recombination |
| wikipathways | WP2942 | DDX1 as a regulatory component of the Drosha microprocessor |
| wikipathways | WP3878 | ATM Signaling Network in Development and Disease |
| wikipathways | WP438 | Non-homologous end joining |
| wikipathways | WP707 | DNA Damage Response |
| reactome | R-HSA-1474165 | Reproduction |
| reactome | R-HSA-1500620 | Meiosis |
| reactome | R-HSA-1640170 | Cell Cycle |
| reactome | R-HSA-1640170 | Cell Cycle |
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-1834941 | STING mediated induction of host immune responses |
| reactome | R-HSA-1834949 | Cytosolic sensors of pathogen-associated DNA |
| reactome | R-HSA-212436 | Generic Transcription Pathway |
| reactome | R-HSA-2262752 | Cellular responses to stress |
| reactome | R-HSA-2559583 | Cellular Senescence |
| reactome | R-HSA-2559586 | DNA Damage/Telomere Stress Induced Senescence |
| reactome | R-HSA-3270619 | IRF3-mediated induction of type I IFN |
| reactome | R-HSA-3700989 | Transcriptional Regulation by TP53 |
| reactome | R-HSA-5633007 | Regulation of TP53 Activity |
| reactome | R-HSA-5685938 | HDR through Single Strand Annealing (SSA) |
| reactome | R-HSA-5685939 | HDR through MMEJ (alt-NHEJ) |
| reactome | R-HSA-5685942 | HDR through Homologous Recombination (HRR) |
| reactome | R-HSA-5693532 | DNA Double-Strand Break Repair |
| reactome | R-HSA-5693537 | Resolution of D-Loop Structures |
| reactome | R-HSA-5693538 | Homology Directed Repair |
| reactome | R-HSA-5693548 | Sensing of DNA Double Strand Breaks |
| reactome | R-HSA-5693554 | Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) |
| reactome | R-HSA-5693565 | Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks |
| reactome | R-HSA-5693567 | HDR through Homologous Recombination (HRR) or Single Strand Annealing (SSA) |
| reactome | R-HSA-5693568 | Resolution of D-loop Structures through Holliday Junction Intermediates |
| reactome | R-HSA-5693571 | Nonhomologous End-Joining (NHEJ) |
| reactome | R-HSA-5693579 | Homologous DNA Pairing and Strand Exchange |
| reactome | R-HSA-5693606 | DNA Double Strand Break Response |
| reactome | R-HSA-5693607 | Processing of DNA double-strand break ends |
| reactome | R-HSA-5693616 | Presynaptic phase of homologous DNA pairing and strand exchange |
| reactome | R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation |
| reactome | R-HSA-69473 | G2/M DNA damage checkpoint |
| reactome | R-HSA-69481 | G2/M Checkpoints |
| reactome | R-HSA-69620 | Cell Cycle Checkpoints |
| reactome | R-HSA-73857 | RNA Polymerase II Transcription |
| reactome | R-HSA-73894 | DNA Repair |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| reactome | R-HSA-8953897 | Cellular responses to external stimuli |
| reactome | R-HSA-912446 | Meiotic recombination |
| biocarta | atrbrcapathway | role of brca1 brca2 and atr in cancer susceptibility |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD150 | RITA | 4 |
| iGMDRD532 | Olaparib | 1 |
| iGMDRD116 | CD437 | 3 |
| iGMDRD427 | ABT737 | 3 |
| iGMDRD670 | ML 210 | 2 |
| iGMDRD345 | Compound 10b [PMID: 11504634] | 4 |
| iGMDRD795 | BMN 673 | 1 |
| iGMDRD512 | nutlin 3 | 2 |
| iGMDRD97 | Bexarotene | 2 |
| iGMDRD375 | GW-405833 | 2 |
| iGMDRD211 | (1S,3R)-RSL3 | 3 |
| iGMDRD280 | CYTOCHALASIN B | 1 |
| iGMDRD177 | Teniposide | 2 |
| iGMDRD123 | Isoevodiamine | 2 |
| iGMDRD351 | GW843682X | 3 |
| iGMDRD61 | Kinetin riboside | 10 |
| iGMDRD341 | Triacsin c | 2 |
| iGMDRD885 | Compound 110 | 2 |
| iGMDRD415 | LE-135 | 2 |
| iGMDRD187 | BRD9876 | 3 |
| iGMDRD782 | DC-45-A2 | 4 |
| iGMDRD171 | Pemetrexed | 2 |
| iGMDRD137 | Indisulam | 2 |
| iGMDRD505 | Pevonedistat | 4 |
| iGMDRD399 | Selumetinib | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in MRE11
CLASSFICATION
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