NR2F1
Summary: The protein encoded by this gene is a nuclear hormone receptor and transcriptional regulator. The encoded protein acts as a homodimer and binds to 5'-AGGTCA-3' repeats. Defects in this gene are a cause of Bosch-Boonstra optic atrophy syndrome (BBOAS). [provided by RefSeq, Apr 2014].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| nuclear receptor subfamily 2 group F member 1 | MIM:132890 | Ensembl:ENSG00000175745 | HGNC:HGNC:7975 | PA31758 | 5q15 |
GO terms in NR2F1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IDA | GO:0005829 | cytosol |
| BP | IDA | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| BP | TAS | GO:0006367 | transcription initiation from RNA polymerase II promoter |
| BP | TAS | GO:0007165 | signal transduction |
| BP | IEA | GO:0030522 | intracellular receptor signaling pathway |
| BP | IEA | GO:0043401 | steroid hormone mediated signaling pathway |
| BP | IEA | GO:1903508 | positive regulation of nucleic acid-templated transcription |
| MF | IDA | GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding |
| MF | ISM | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | NAS | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | IDA | GO:0001078 | transcriptional repressor activity, RNA polymerase II proximal promoter sequence-specific DNA binding |
| MF | IDA | GO:0003700 | DNA-binding transcription factor activity |
| MF | IEA | GO:0003707 | steroid hormone receptor activity |
| MF | TAS | GO:0003713 | transcription coactivator activity |
| MF | IEA | GO:0004879 | nuclear receptor activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0008270 | zinc ion binding |
| MF | IDA | GO:0043565 | sequence-specific DNA binding |
Gene expression in normal tissue: NR2F1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in NR2F1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-212436 | Generic Transcription Pathway |
| reactome | R-HSA-383280 | Nuclear Receptor transcription pathway |
| reactome | R-HSA-73857 | RNA Polymerase II Transcription |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| biocarta | pparapathway | mechanism of gene regulation by peroxisome proliferators via ppara |
| wikipathways | WP170 | Nuclear Receptors |
| wikipathways | WP236 | Adipogenesis |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD154 | NSC23766 | 2 |
| iGMDRD280 | CYTOCHALASIN B | 8 |
| iGMDRD123 | Isoevodiamine | 2 |
| iGMDRD61 | Kinetin riboside | 1 |
| iGMDRD698 | Neratinib | 1 |
| iGMDRD85 | Ursolic acid | 1 |
| iGMDRD446 | LY 2183240 | 2 |
| iGMDRD150 | RITA | 2 |
| iGMDRD248 | BRD4354 | 1 |
| iGMDRD148 | Pifithrin-mu | 5 |
| iGMDRD772 | BRD4770 | 2 |
| iGMDRD584 | VER 155008 | 3 |
| iGMDRD84 | Lovastatin acid | 3 |
| iGMDRD356 | PNU-74654 | 1 |
| iGMDRD64 | Parbendazole | 2 |
| iGMDRD398 | Sepantronium | 3 |
| iGMDRD329 | Merck60 | 4 |
| iGMDRD887 | Compound 23 citrate | 1 |
| iGMDRD74 | Idarubicin | 2 |
| iGMDRD100 | Zebularine | 2 |
| iGMDRD188 | Piperlongumine | 2 |
| iGMDRD286 | Nsc 632839 | 5 |
| iGMDRD870 | BRD63610 | 6 |
| iGMDRD481 | Dactolisib | 2 |
| iGMDRD434 | BMS-536924 | 1 |
| iGMDRD705 | Nakiterpiosin | 3 |
| iGMDRD289 | Parthenolide | 3 |
| iGMDRD5 | Tyrphostin AG 1478 | 6 |
| iGMDRD138 | PX 12 | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in NR2F1
CLASSFICATION
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