DTX1
Summary: Studies in Drosophila have identified this gene as encoding a positive regulator of the Notch-signaling pathway. The human gene encodes a protein of unknown function; however, it may play a role in basic helix-loop-helix transcription factor activity. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| deltex E3 ubiquitin ligase 1 | MIM:602582 | Ensembl:ENSG00000135144 | HGNC:HGNC:3060 | PA27514 | 12q24.13 |
GO terms in DTX1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | TAS | GO:0003713 | transcription coactivator activity |
| MF | IDA | GO:0005112 | Notch binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0008270 | zinc ion binding |
| MF | IEA | GO:0016740 | transferase activity |
| MF | IEA | GO:0017124 | SH3 domain binding |
| MF | IPI | GO:0031625 | ubiquitin protein ligase binding |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | TAS | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| CC | IDA | GO:0016604 | nuclear body |
| BP | NAS | GO:0006351 | transcription, DNA-templated |
| BP | TAS | GO:0006366 | transcription by RNA polymerase II |
| BP | TAS | GO:0007166 | cell surface receptor signaling pathway |
| BP | TAS | GO:0007219 | Notch signaling pathway |
| BP | IGI | GO:0008593 | regulation of Notch signaling pathway |
| BP | IEA | GO:0010001 | glial cell differentiation |
| BP | IEA | GO:0016567 | protein ubiquitination |
| BP | IEA | GO:0045581 | negative regulation of T cell differentiation |
| BP | IGI | GO:0045665 | negative regulation of neuron differentiation |
| BP | IEA | GO:1903508 | positive regulation of nucleic acid-templated transcription |
| BP | IEA | GO:1990830 | cellular response to leukemia inhibitory factor |
Gene expression in normal tissue: DTX1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in DTX1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-157118 | Signaling by NOTCH |
| reactome | R-HSA-157118 | Signaling by NOTCH |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-1980143 | Signaling by NOTCH1 |
| reactome | R-HSA-1980143 | Signaling by NOTCH1 |
| reactome | R-HSA-2122948 | Activated NOTCH1 Transmits Signal to the Nucleus |
| reactome | R-HSA-2122948 | Activated NOTCH1 Transmits Signal to the Nucleus |
| wikipathways | WP268 | Notch Signaling Pathway |
| wikipathways | WP4242 | Notch Signaling Pathway |
| wikipathways | WP61 | Notch Signaling Pathway |
| pid | ps1pathway | Presenilin action in Notch and Wnt signaling |
| netpath | Pathway_Notch | Notch |
| kegg | hsa04330 | Notch signaling pathway - Homo sapiens (human) |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD782 | DC-45-A2 | 3 |
| iGMDRD171 | Pemetrexed | 1 |
| iGMDRD801 | 2,4-dideoxy-DC-45-A2 | 2 |
| iGMDRD309 | 17AAG | 1 |
| iGMDRD187 | BRD9876 | 1 |
| iGMDRD255 | SB225002 | 2 |
| iGMDRD60 | Quinoclamine | 2 |
| iGMDRD64 | Parbendazole | 3 |
| iGMDRD23 | Gossypol | 4 |
| iGMDRD356 | PNU-74654 | 3 |
| iGMDRD451 | Serdemetan | 3 |
| iGMDRD188 | Piperlongumine | 2 |
| iGMDRD74 | Idarubicin | 2 |
| iGMDRD577 | BIX01294 | 4 |
| iGMDRD427 | ABT737 | 1 |
| iGMDRD144 | NSC95397 | 2 |
| iGMDRD483 | SCH-529074 | 3 |
| iGMDRD126 | Tipifarnib | 5 |
| iGMDRD151 | CHM-1 | 1 |
| iGMDRD297 | Austocystin D | 4 |
| iGMDRD679 | Bistramide A | 4 |
| iGMDRD280 | CYTOCHALASIN B | 3 |
| iGMDRD375 | GW-405833 | 6 |
| iGMDRD446 | LY 2183240 | 2 |
| iGMDRD152 | 179324-69-7 | 1 |
| iGMDRD61 | Kinetin riboside | 2 |
| iGMDRD193 | Fqi1 | 3 |
| iGMDRD705 | Nakiterpiosin | 2 |
| iGMDRD434 | BMS-536924 | 3 |
| iGMDRD77 | Itraconazole | 2 |
| iGMDRD267 | Oligomycin A | 1 |
| iGMDRD103 | SN-38 | 3 |
| iGMDRD158 | NSC141540 | 3 |
| iGMDRD271 | Brefeldin A | 2 |
| iGMDRD137 | Indisulam | 5 |
| iGMDRD505 | Pevonedistat | 2 |
| iGMDRD300 | Tozasertib | 1 |
| iGMDRD263 | AACOCF3 | 3 |
| iGMDRD353 | PD0325901 | 2 |
| iGMDRD414 | MST-312 | 2 |
| iGMDRD871 | BRD6368 | 2 |
| iGMDRD286 | Nsc 632839 | 3 |
| iGMDRD872 | BRD7137 | 2 |
| iGMDRD116 | CD437 | 3 |
| iGMDRD150 | RITA | 2 |
| iGMDRD405 | PIK-75 | 3 |
| iGMDRD901 | ELCPK | 3 |
| iGMDRD177 | Teniposide | 1 |
| iGMDRD883 | CIL55A | 3 |
| iGMDRD154 | NSC23766 | 3 |
| iGMDRD698 | Neratinib | 3 |
| iGMDRD314 | Tanespimycin | 2 |
| iGMDRD499 | PDMP | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in DTX1
CLASSFICATION
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