DTX1

Summary: Studies in Drosophila have identified this gene as encoding a positive regulator of the Notch-signaling pathway. The human gene encodes a protein of unknown function; however, it may play a role in basic helix-loop-helix transcription factor activity. [provided by RefSeq, Jul 2008].

Loading, please wait...
Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Namedeltex E3 ubiquitin ligase 1
OMIM IDMIM:602582
Ensembl IDEnsembl:ENSG00000135144
HGNC IDHGNC:HGNC:3060
PHARMGKB IDPA27514
Map Location12q24.13

GO terms in DTX1


Loading, please wait...
Term Type
Evidence Type
GO Term ID
GO Des.
MF TAS GO:0003713 transcription coactivator activity
MF IDA GO:0005112 Notch binding
MF IPI GO:0005515 protein binding
MF IEA GO:0008270 zinc ion binding
MF IEA GO:0016740 transferase activity
MF IEA GO:0017124 SH3 domain binding
Showing 1 to 6 of 23 rows rows per page

Gene expression in normal tissue: DTX1

Gene-model tissue-cancer distribution: Bubble Plot

LUNtissue: LUN cancer: LUNG model num: 0LUNGtissue: LUNG cancer: undefined model num: 47undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 55undefinedtissue: undefined cancer: SMALL_CELL_CARCINOMA model num: 3BOWEtissue: BOWE cancer: BOWEL model num: 0BOWELtissue: BOWEL cancer: undefined model num: 27

Gene-drug pathway distribution

undefined43DNA replication2Protein stability and degradation2ERK MAPK signaling1Mitosis1p53 pathway1One carbon pool by folate1Biosynthesis of secondary metabolites1Proteasome1

Pathways in DTX1


Loading, please wait...
Database
Pathway ID
Pathway Des.
reactome R-HSA-157118 Signaling by NOTCH
reactome R-HSA-157118 Signaling by NOTCH
reactome R-HSA-162582 Signal Transduction
reactome R-HSA-162582 Signal Transduction
reactome R-HSA-1980143 Signaling by NOTCH1
reactome R-HSA-1980143 Signaling by NOTCH1
Showing 1 to 6 of 14 rows rows per page

Gene-Drug: Aster Plot


Loading, please wait...
Drug ID
Drug Name
Model Num.
iGMDRD782 DC-45-A2 3
iGMDRD171 Pemetrexed 1
iGMDRD801 2,4-dideoxy-DC-45-A2 2
iGMDRD309 17AAG 1
Showing 1 to 4 of 53 rows rows per page

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in DTX1

Loading, please wait...
Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

​​​​

SITE
DATATYPES
CLASSFICATION
Map

Copyright © 2018 Modellab | All Rights Reserved

Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.