DTX1


Summary: Studies in Drosophila have identified this gene as encoding a positive regulator of the Notch-signaling pathway. The human gene encodes a protein of unknown function; however, it may play a role in basic helix-loop-helix transcription factor activity. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
deltex E3 ubiquitin ligase 1MIM:602582Ensembl:ENSG00000135144HGNC:HGNC:3060PA2751412q24.13

GO terms in DTX1


Term TypeEvidence TypeGO Term IDGO Des.
MFTASGO:0003713transcription coactivator activity
MFIDAGO:0005112Notch binding
MFIPIGO:0005515protein binding
MFIEAGO:0008270zinc ion binding
MFIEAGO:0016740transferase activity
MFIEAGO:0017124SH3 domain binding
MFIPIGO:0031625ubiquitin protein ligase binding
CCIDAGO:0005654nucleoplasm
CCTASGO:0005737cytoplasm
CCIDAGO:0005829cytosol
CCTASGO:0005829cytosol
CCIDAGO:0016604nuclear body
BPNASGO:0006351transcription, DNA-templated
BPTASGO:0006366transcription by RNA polymerase II
BPTASGO:0007166cell surface receptor signaling pathway
BPTASGO:0007219Notch signaling pathway
BPIGIGO:0008593regulation of Notch signaling pathway
BPIEAGO:0010001glial cell differentiation
BPIEAGO:0016567protein ubiquitination
BPIEAGO:0045581negative regulation of T cell differentiation
BPIGIGO:0045665negative regulation of neuron differentiation
BPIEAGO:1903508positive regulation of nucleic acid-templated transcription
BPIEAGO:1990830cellular response to leukemia inhibitory factor

Gene expression in normal tissue: DTX1

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in DTX1


DatabasePathway IDPathway Des.
reactomeR-HSA-157118Signaling by NOTCH
reactomeR-HSA-157118Signaling by NOTCH
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-1980143Signaling by NOTCH1
reactomeR-HSA-1980143Signaling by NOTCH1
reactomeR-HSA-2122948Activated NOTCH1 Transmits Signal to the Nucleus
reactomeR-HSA-2122948Activated NOTCH1 Transmits Signal to the Nucleus
wikipathwaysWP268Notch Signaling Pathway
wikipathwaysWP4242Notch Signaling Pathway
wikipathwaysWP61Notch Signaling Pathway
pidps1pathwayPresenilin action in Notch and Wnt signaling
netpathPathway_NotchNotch
kegghsa04330Notch signaling pathway - Homo sapiens (human)

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD782DC-45-A23
iGMDRD171Pemetrexed1
iGMDRD8012,4-dideoxy-DC-45-A22
iGMDRD30917AAG1
iGMDRD187BRD98761
iGMDRD255SB2250022
iGMDRD60Quinoclamine2
iGMDRD64Parbendazole3
iGMDRD23Gossypol4
iGMDRD356PNU-746543
iGMDRD451Serdemetan3
iGMDRD188Piperlongumine2
iGMDRD74Idarubicin2
iGMDRD577BIX012944
iGMDRD427ABT7371
iGMDRD144NSC953972
iGMDRD483SCH-5290743
iGMDRD126Tipifarnib5
iGMDRD151CHM-11
iGMDRD297Austocystin D4
iGMDRD679Bistramide A4
iGMDRD280CYTOCHALASIN B3
iGMDRD375GW-4058336
iGMDRD446LY 21832402
iGMDRD152179324-69-71
iGMDRD61Kinetin riboside2
iGMDRD193Fqi13
iGMDRD705Nakiterpiosin2
iGMDRD434BMS-5369243
iGMDRD77Itraconazole2
iGMDRD267Oligomycin A1
iGMDRD103SN-383
iGMDRD158NSC1415403
iGMDRD271Brefeldin A2
iGMDRD137Indisulam5
iGMDRD505Pevonedistat2
iGMDRD300Tozasertib1
iGMDRD263AACOCF33
iGMDRD353PD03259012
iGMDRD414MST-3122
iGMDRD871BRD63682
iGMDRD286Nsc 6328393
iGMDRD872BRD71372
iGMDRD116CD4373
iGMDRD150RITA2
iGMDRD405PIK-753
iGMDRD901ELCPK3
iGMDRD177Teniposide1
iGMDRD883CIL55A3
iGMDRD154NSC237663
iGMDRD698Neratinib3
iGMDRD314Tanespimycin2
iGMDRD499PDMP1

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in DTX1

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