DNMT3A


Summary: CpG methylation is an epigenetic modification that is important for embryonic development, imprinting, and X-chromosome inactivation. Studies in mice have demonstrated that DNA methylation is required for mammalian development. This gene encodes a DNA methyltransferase that is thought to function in de novo methylation, rather than maintenance methylation. The protein localizes to the cytoplasm and nucleus and its expression is developmentally regulated. [provided by RefSeq, Mar 2016].

Loading, please wait...
Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location

GO terms in DNMT3A


Loading, please wait...
Term Type
Evidence Type
GO Term ID
GO Des.
MF ISA GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
MF IDA GO:0003677 DNA binding
MF IEA GO:0003682 chromatin binding
MF IDA GO:0003886 DNA (cytosine-5-)-methyltransferase activity
MF IPI GO:0005515 protein binding
MF TAS GO:0009008 DNA-methyltransferase activity
Showing 1 to 6 of 39 rows rows per page

Gene expression in normal tissue: DNMT3A

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in DNMT3A


Loading, please wait...
Database
Pathway ID
Pathway Des.
wikipathways WP2004 miR-targeted genes in lymphocytes - TarBase
wikipathways WP2005 miR-targeted genes in muscle cell - TarBase
wikipathways WP241 One Carbon Metabolism
wikipathways WP2525 Trans-sulfuration and one carbon metabolism
wikipathways WP3657 Hematopoietic Stem Cell Gene Regulation by GABP alpha-beta Complex
wikipathways WP3940 One carbon metabolism and related pathways
Showing 1 to 6 of 23 rows rows per page

Gene-Drug: Aster Plot


Loading, please wait...
Drug ID
Drug Name
Model Num.
iGMDRD74 Idarubicin 1
iGMDRD65 Daunorubicin 3
iGMDRD176 Decitabine 1
iGMDRD309 17AAG 1
Showing 1 to 4 of 4 rows

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in DNMT3A

Loading, please wait...
Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

​​​​