ITGB1

Summary: Integrins are heterodimeric proteins made up of alpha and beta subunits. At least 18 alpha and 8 beta subunits have been described in mammals. Integrin family members are membrane receptors involved in cell adhesion and recognition in a variety of processes including embryogenesis, hemostasis, tissue repair, immune response and metastatic diffusion of tumor cells. This gene encodes a beta subunit. Multiple alternatively spliced transcript variants which encode different protein isoforms have been found for this gene. [provided by RefSeq, Jul 2008].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Nameintegrin subunit beta 1
OMIM IDMIM:135630
Ensembl IDEnsembl:ENSG00000150093
HGNC IDHGNC:HGNC:6153
PHARMGKB IDPA29953
Map Location10p11.22

GO terms in ITGB1


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Term Type
Evidence Type
GO Term ID
GO Des.
CC TAS GO:0001726 ruffle
CC IDA GO:0005737 cytoplasm
CC IDA GO:0005886 plasma membrane
CC NAS GO:0005886 plasma membrane
CC TAS GO:0005886 plasma membrane
CC HDA GO:0005925 focal adhesion
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Gene expression in normal tissue: ITGB1

16 tissues mixtureadiposeadrenalbrainbreastcolonheartkidneyliverlunglymph nodeovaryprostateskeletal muscletestesthyroidwhite blood cells

Gene-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 48undefinedtissue: undefined cancer: NON_SMALL_CELL_CARCINOMA model num: 3BOWEtissue: BOWE cancer: BOWEL model num: 0BOWELtissue: BOWEL cancer: undefined model num: 17LUNtissue: LUN cancer: LUNG model num: 0LUNGtissue: LUNG cancer: undefined model num: 11OVARtissue: OVAR cancer: OVARY model num: 0OVARYtissue: OVARY cancer: undefined model num: 10BREAStissue: BREAS cancer: BREAST model num: 0BREASTtissue: BREAST cancer: undefined model num: 1

Gene-drug pathway distribution

undefined16Cell cycle2RTK signaling1PI3K/MTOR signaling1p53 pathway1Chromatin histone acetylation1One carbon pool by folate1Apoptosis regulation1ERK MAPK signaling1Metabolism1

Pathways in ITGB1


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Database
Pathway ID
Pathway Des.
reactome R-HSA-109582 Hemostasis
reactome R-HSA-109582 Hemostasis
reactome R-HSA-1266738 Developmental Biology
reactome R-HSA-1266738 Developmental Biology
reactome R-HSA-1280215 Cytokine Signaling in Immune system
reactome R-HSA-1280218 Adaptive Immune System
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD121 GMX1778 3
iGMDRD187 BRD9876 6
iGMDRD6 AM-580 2
iGMDRD434 BMS-536924 6
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in ITGB1

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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