ITGB1
Summary: Integrins are heterodimeric proteins made up of alpha and beta subunits. At least 18 alpha and 8 beta subunits have been described in mammals. Integrin family members are membrane receptors involved in cell adhesion and recognition in a variety of processes including embryogenesis, hemostasis, tissue repair, immune response and metastatic diffusion of tumor cells. This gene encodes a beta subunit. Multiple alternatively spliced transcript variants which encode different protein isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| integrin subunit beta 1 | MIM:135630 | Ensembl:ENSG00000150093 | HGNC:HGNC:6153 | PA29953 | 10p11.22 |
GO terms in ITGB1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | TAS | GO:0001726 | ruffle |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005886 | plasma membrane |
| CC | NAS | GO:0005886 | plasma membrane |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | HDA | GO:0005925 | focal adhesion |
| CC | IBA | GO:0005925 | focal adhesion |
| CC | IDA | GO:0005925 | focal adhesion |
| CC | IDA | GO:0005925 | focal adhesion |
| CC | IBA | GO:0008305 | integrin complex |
| CC | NAS | GO:0008305 | integrin complex |
| CC | IEA | GO:0009897 | external side of plasma membrane |
| CC | HDA | GO:0009986 | cell surface |
| CC | IBA | GO:0009986 | cell surface |
| CC | IDA | GO:0009986 | cell surface |
| CC | IEA | GO:0014704 | intercalated disc |
| CC | HDA | GO:0016020 | membrane |
| CC | IEA | GO:0030027 | lamellipodium |
| CC | IDA | GO:0030175 | filopodium |
| CC | IDA | GO:0031594 | neuromuscular junction |
| CC | IEA | GO:0032154 | cleavage furrow |
| CC | IDA | GO:0032587 | ruffle membrane |
| CC | NAS | GO:0032587 | ruffle membrane |
| CC | IDA | GO:0034665 | integrin alpha1-beta1 complex |
| CC | IDA | GO:0034666 | integrin alpha2-beta1 complex |
| CC | IDA | GO:0034667 | integrin alpha3-beta1 complex |
| CC | IEA | GO:0034677 | integrin alpha7-beta1 complex |
| CC | TAS | GO:0034678 | integrin alpha8-beta1 complex |
| CC | IDA | GO:0034680 | integrin alpha10-beta1 complex |
| CC | IDA | GO:0034681 | integrin alpha11-beta1 complex |
| CC | IEA | GO:0035748 | myelin sheath abaxonal region |
| CC | IDA | GO:0042383 | sarcolemma |
| CC | IEA | GO:0042470 | melanosome |
| CC | IEA | GO:0043197 | dendritic spine |
| CC | IDA | GO:0043235 | receptor complex |
| CC | IDA | GO:0045121 | membrane raft |
| CC | IDA | GO:0048471 | perinuclear region of cytoplasm |
| CC | IEA | GO:0055037 | recycling endosome |
| CC | HDA | GO:0070062 | extracellular exosome |
| CC | IDA | GO:0071438 | invadopodium membrane |
| CC | IEA | GO:0097060 | synaptic membrane |
| BP | IEA | GO:0000082 | G1/S transition of mitotic cell cycle |
| BP | IEA | GO:0001701 | in utero embryonic development |
| BP | IEA | GO:0001708 | cell fate specification |
| BP | IEA | GO:0002042 | cell migration involved in sprouting angiogenesis |
| BP | TAS | GO:0006968 | cellular defense response |
| BP | TAS | GO:0007156 | homophilic cell adhesion via plasma membrane adhesion molecules |
| BP | IDA | GO:0007159 | leukocyte cell-cell adhesion |
| BP | IBA | GO:0007160 | cell-matrix adhesion |
| BP | IMP | GO:0007160 | cell-matrix adhesion |
| BP | IGI | GO:0007161 | calcium-independent cell-matrix adhesion |
| BP | IMP | GO:0007179 | transforming growth factor beta receptor signaling pathway |
| BP | IBA | GO:0007229 | integrin-mediated signaling pathway |
| BP | IMP | GO:0007229 | integrin-mediated signaling pathway |
| BP | IEA | GO:0008284 | positive regulation of cell proliferation |
| BP | IEA | GO:0008354 | germ cell migration |
| BP | IEA | GO:0008542 | visual learning |
| BP | IDA | GO:0010710 | regulation of collagen catabolic process |
| BP | IBA | GO:0016477 | cell migration |
| BP | TAS | GO:0016477 | cell migration |
| BP | TAS | GO:0019221 | cytokine-mediated signaling pathway |
| BP | IEA | GO:0021943 | formation of radial glial scaffolds |
| BP | IC | GO:0030183 | B cell differentiation |
| BP | TAS | GO:0030198 | extracellular matrix organization |
| BP | IMP | GO:0031589 | cell-substrate adhesion |
| BP | ISS | GO:0031623 | receptor internalization |
| BP | IBA | GO:0033627 | cell adhesion mediated by integrin |
| BP | IDA | GO:0033627 | cell adhesion mediated by integrin |
| BP | IEP | GO:0033631 | cell-cell adhesion mediated by integrin |
| BP | IMP | GO:0034113 | heterotypic cell-cell adhesion |
| BP | IEA | GO:0035024 | negative regulation of Rho protein signal transduction |
| BP | IGI | GO:0043065 | positive regulation of apoptotic process |
| BP | IMP | GO:0043149 | stress fiber assembly |
| BP | IMP | GO:0043547 | positive regulation of GTPase activity |
| BP | IEA | GO:0045214 | sarcomere organization |
| BP | IEA | GO:0045596 | negative regulation of cell differentiation |
| BP | IMP | GO:0045766 | positive regulation of angiogenesis |
| BP | IEA | GO:0046718 | viral entry into host cell |
| BP | IEP | GO:0048333 | mesodermal cell differentiation |
| BP | IEA | GO:0048675 | axon extension |
| BP | IEA | GO:0048813 | dendrite morphogenesis |
| BP | TAS | GO:0050776 | regulation of immune response |
| BP | TAS | GO:0050900 | leukocyte migration |
| BP | IMP | GO:0050901 | leukocyte tethering or rolling |
| BP | IEA | GO:0051726 | regulation of cell cycle |
| BP | IDA | GO:0051897 | positive regulation of protein kinase B signaling |
| BP | IEA | GO:0055007 | cardiac muscle cell differentiation |
| BP | ISS | GO:0071404 | cellular response to low-density lipoprotein particle stimulus |
| BP | IEA | GO:0071711 | basement membrane organization |
| BP | IDA | GO:1903078 | positive regulation of protein localization to plasma membrane |
| BP | IDA | GO:2000273 | positive regulation of signaling receptor activity |
| BP | IMP | GO:2000811 | negative regulation of anoikis |
| MF | IEA | GO:0001618 | virus receptor activity |
| MF | IBA | GO:0001968 | fibronectin binding |
| MF | IPI | GO:0001968 | fibronectin binding |
| MF | IPI | GO:0002020 | protease binding |
| MF | IDA | GO:0003779 | actin binding |
| MF | IBA | GO:0005178 | integrin binding |
| MF | IEA | GO:0005178 | integrin binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | TAS | GO:0015026 | coreceptor activity |
| MF | IBA | GO:0019960 | C-X3-C chemokine binding |
| MF | IDA | GO:0019960 | C-X3-C chemokine binding |
| MF | IBA | GO:0043236 | laminin binding |
| MF | IEA | GO:0043236 | laminin binding |
| MF | IPI | GO:0044877 | protein-containing complex binding |
| MF | HDA | GO:0045296 | cadherin binding |
| MF | IEA | GO:0046872 | metal ion binding |
| MF | IDA | GO:0046982 | protein heterodimerization activity |
| MF | NAS | GO:0046982 | protein heterodimerization activity |
| MF | IPI | GO:0050839 | cell adhesion molecule binding |
| MF | IBA | GO:0098639 | collagen binding involved in cell-matrix adhesion |
| MF | IMP | GO:0098639 | collagen binding involved in cell-matrix adhesion |
Gene expression in normal tissue: ITGB1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in ITGB1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-109582 | Hemostasis |
| reactome | R-HSA-109582 | Hemostasis |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-1280218 | Adaptive Immune System |
| reactome | R-HSA-1474244 | Extracellular matrix organization |
| reactome | R-HSA-1474244 | Extracellular matrix organization |
| reactome | R-HSA-1500931 | Cell-Cell communication |
| reactome | R-HSA-1566948 | Elastic fibre formation |
| reactome | R-HSA-1566977 | Fibronectin matrix formation |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-194315 | Signaling by Rho GTPases |
| reactome | R-HSA-195258 | RHO GTPase Effectors |
| reactome | R-HSA-198933 | Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell |
| reactome | R-HSA-202733 | Cell surface interactions at the vascular wall |
| reactome | R-HSA-210991 | Basigin interactions |
| reactome | R-HSA-2129379 | Molecules associated with elastic fibres |
| reactome | R-HSA-216083 | Integrin cell surface interactions |
| reactome | R-HSA-216083 | Integrin cell surface interactions |
| reactome | R-HSA-3000157 | Laminin interactions |
| reactome | R-HSA-3000157 | Laminin interactions |
| reactome | R-HSA-3000170 | Syndecan interactions |
| reactome | R-HSA-3000171 | Non-integrin membrane-ECM interactions |
| reactome | R-HSA-3000178 | ECM proteoglycans |
| reactome | R-HSA-373755 | Semaphorin interactions |
| reactome | R-HSA-373760 | L1CAM interactions |
| reactome | R-HSA-373760 | L1CAM interactions |
| reactome | R-HSA-416700 | Other semaphorin interactions |
| reactome | R-HSA-422475 | Axon guidance |
| reactome | R-HSA-422475 | Axon guidance |
| reactome | R-HSA-445144 | Signal transduction by L1 |
| reactome | R-HSA-446343 | Localization of the PINCH-ILK-PARVIN complex to focal adhesions |
| reactome | R-HSA-446353 | Cell-extracellular matrix interactions |
| reactome | R-HSA-446728 | Cell junction organization |
| reactome | R-HSA-447041 | CHL1 interactions |
| reactome | R-HSA-449147 | Signaling by Interleukins |
| reactome | R-HSA-5663220 | RHO GTPases Activate Formins |
| reactome | R-HSA-6785807 | Interleukin-4 and Interleukin-13 signaling |
| reactome | R-HSA-6806834 | Signaling by MET |
| reactome | R-HSA-75892 | Platelet Adhesion to exposed collagen |
| reactome | R-HSA-8874081 | MET activates PTK2 signaling |
| reactome | R-HSA-8875513 | MET interacts with TNS proteins |
| reactome | R-HSA-8875878 | MET promotes cell motility |
| reactome | R-HSA-9006934 | Signaling by Receptor Tyrosine Kinases |
| biocarta | agrpathway | agrin in postsynaptic differentiation |
| biocarta | bcellsurvivalpathway | b cell survival pathway |
| biocarta | ecmpathway | erk and pi-3 kinase are necessary for collagen binding in corneal epithelia |
| biocarta | integrinpathway | integrin signaling pathway |
| biocarta | mcalpainpathway | mcalpain and friends in cell motility |
| biocarta | ptenpathway | pten dependent cell cycle arrest and apoptosis |
| biocarta | ucalpainpathway | ucalpain and friends in cell spread |
| pid | a4b7_pathway | a4b7 Integrin signaling |
| pid | a6b1_a6b4_integrin_pathway | a6b1 and a6b4 Integrin signaling |
| pid | angiopoietinreceptor_pathway | Angiopoietin receptor Tie2-mediated signaling |
| pid | arf6_traffickingpathway | Arf6 trafficking events |
| pid | fak_pathway | Signaling events mediated by focal adhesion kinase |
| pid | integrin1_pathway | Beta1 integrin cell surface interactions |
| pid | integrin_a4b1_pathway | Alpha4 beta1 integrin signaling events |
| pid | integrin_a9b1_pathway | Alpha9 beta1 integrin signaling events |
| pid | lymphangiogenesis_pathway | VEGFR3 signaling in lymphatic endothelium |
| pid | myc_represspathway | Validated targets of C-MYC transcriptional repression |
| pid | plexind1_pathway | Plexin-D1 Signaling |
| pid | prlsignalingeventspathway | Signaling events mediated by PRL |
| pid | reelinpathway | Reelin signaling pathway |
| pid | rhoa_pathway | RhoA signaling pathway |
| pid | syndecan_2_pathway | Syndecan-2-mediated signaling events |
| pid | syndecan_4_pathway | Syndecan-4-mediated signaling events |
| pid | tcptp_pathway | Signaling events mediated by TCPTP |
| pid | upa_upar_pathway | Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling |
| netpath | Pathway_EGFR1 | EGFR1 |
| netpath | Pathway_Gastrin | Gastrin |
| netpath | Pathway_Prolactin | Prolactin |
| kegg | hsa04015 | Rap1 signaling pathway - Homo sapiens (human) |
| kegg | hsa04145 | Phagosome - Homo sapiens (human) |
| kegg | hsa04151 | PI3K-Akt signaling pathway - Homo sapiens (human) |
| kegg | hsa04360 | Axon guidance - Homo sapiens (human) |
| kegg | hsa04510 | Focal adhesion - Homo sapiens (human) |
| kegg | hsa04512 | ECM-receptor interaction - Homo sapiens (human) |
| kegg | hsa04514 | Cell adhesion molecules (CAMs) - Homo sapiens (human) |
| kegg | hsa04530 | Tight junction - Homo sapiens (human) |
| kegg | hsa04611 | Platelet activation - Homo sapiens (human) |
| kegg | hsa04670 | Leukocyte transendothelial migration - Homo sapiens (human) |
| kegg | hsa04810 | Regulation of actin cytoskeleton - Homo sapiens (human) |
| kegg | hsa05100 | Bacterial invasion of epithelial cells - Homo sapiens (human) |
| kegg | hsa05130 | Pathogenic Escherichia coli infection - Homo sapiens (human) |
| kegg | hsa05131 | Shigellosis - Homo sapiens (human) |
| kegg | hsa05133 | Pertussis - Homo sapiens (human) |
| kegg | hsa05140 | Leishmaniasis - Homo sapiens (human) |
| kegg | hsa05145 | Toxoplasmosis - Homo sapiens (human) |
| kegg | hsa05165 | Human papillomavirus infection - Homo sapiens (human) |
| kegg | hsa05200 | Pathways in cancer - Homo sapiens (human) |
| kegg | hsa05205 | Proteoglycans in cancer - Homo sapiens (human) |
| kegg | hsa05222 | Small cell lung cancer - Homo sapiens (human) |
| kegg | hsa05410 | Hypertrophic cardiomyopathy (HCM) - Homo sapiens (human) |
| kegg | hsa05412 | Arrhythmogenic right ventricular cardiomyopathy (ARVC) - Homo sapiens (human) |
| kegg | hsa05414 | Dilated cardiomyopathy (DCM) - Homo sapiens (human) |
| wikipathways | WP185 | Integrin-mediated Cell Adhesion |
| wikipathways | WP2037 | Prolactin Signaling Pathway |
| wikipathways | WP2064 | Neural Crest Differentiation |
| wikipathways | WP2118 | Arrhythmogenic Right Ventricular Cardiomyopathy |
| wikipathways | WP2272 | Pathogenic Escherichia coli infection |
| wikipathways | WP2572 | Primary Focal Segmental Glomerulosclerosis FSGS |
| wikipathways | WP2593 | JAK-STAT |
| wikipathways | WP306 | Focal Adhesion |
| wikipathways | WP313 | Signaling of Hepatocyte Growth Factor Receptor |
| wikipathways | WP3303 | Rac1-Pak1-p38-MMP-2 pathway |
| wikipathways | WP3379 | RHO GTPases Activate Formins |
| wikipathways | WP366 | TGF-beta Signaling Pathway |
| wikipathways | WP3850 | Factors and pathways affecting insulin-like growth factor (IGF1)-Akt signaling |
| wikipathways | WP3888 | VEGFA-VEGFR2 Signaling Pathway |
| wikipathways | WP3932 | Focal Adhesion-PI3K-Akt-mTOR-signaling pathway |
| wikipathways | WP4066 | Interleukin-4 and 13 signaling |
| wikipathways | WP4172 | PI3K-Akt Signaling Pathway |
| wikipathways | WP4180 | Ebola Virus Pathway on Host |
| wikipathways | WP4217 | Ebola Virus Pathway on Host |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD121 | GMX1778 | 3 |
| iGMDRD187 | BRD9876 | 6 |
| iGMDRD6 | AM-580 | 2 |
| iGMDRD434 | BMS-536924 | 6 |
| iGMDRD171 | Pemetrexed | 3 |
| iGMDRD562 | Navitoclax | 3 |
| iGMDRD100 | Zebularine | 6 |
| iGMDRD67 | PENFLURIDOL | 3 |
| iGMDRD74 | Idarubicin | 3 |
| iGMDRD399 | Selumetinib | 3 |
| iGMDRD356 | PNU-74654 | 3 |
| iGMDRD42 | Vorinostat | 9 |
| iGMDRD322 | FK 866 | 3 |
| iGMDRD451 | Serdemetan | 3 |
| iGMDRD64 | Parbendazole | 3 |
| iGMDRD552 | AZD-1775 | 4 |
| iGMDRD512 | nutlin 3 | 6 |
| iGMDRD654 | SL 0101-1 | 1 |
| iGMDRD405 | PIK-75 | 2 |
| iGMDRD397 | Pazopanib | 1 |
| iGMDRD150 | RITA | 2 |
| iGMDRD560 | MK-2206 | 3 |
| iGMDRD351 | GW843682X | 1 |
| iGMDRD634 | SCHEMBL2608041 | 3 |
| iGMDRD435 | BI-2536 | 6 |
| iGMDRD280 | CYTOCHALASIN B | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in ITGB1
CLASSFICATION
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