NEK6


Summary: The protein encoded by this gene is a kinase required for progression through the metaphase portion of mitosis. Inhibition of the encoded protein can lead to apoptosis. This protein also can enhance tumorigenesis by suppressing tumor cell senescence. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Oct 2011].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
OMIM IDMIM:604884
PHARMGKB IDPA31550
Map Location9q33.3

GO terms in NEK6


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Term Type
Evidence Type
GO Term ID
GO Des.
MF IDA GO:0000287 magnesium ion binding
MF IPI GO:0001222 transcription corepressor binding
MF IDA GO:0004674 protein serine/threonine kinase activity
MF TAS GO:0004674 protein serine/threonine kinase activity
MF IPI GO:0005515 protein binding
MF IDA GO:0005524 ATP binding
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Gene expression in normal tissue: NEK6

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in NEK6


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Database
Pathway ID
Pathway Des.
reactome R-HSA-1640170 Cell Cycle
reactome R-HSA-2980766 Nuclear Envelope Breakdown
reactome R-HSA-2980767 Activation of NIMA Kinases NEK9, NEK6, NEK7
reactome R-HSA-3301854 Nuclear Pore Complex (NPC) Disassembly
reactome R-HSA-68875 Mitotic Prophase
reactome R-HSA-68886 M Phase
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD802 4-methylfasudil 6
iGMDRD137 Indisulam 4
iGMDRD405 PIK-75 3
iGMDRD294 Batimastat 2
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in NEK6

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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