NEK6
Summary: The protein encoded by this gene is a kinase required for progression through the metaphase portion of mitosis. Inhibition of the encoded protein can lead to apoptosis. This protein also can enhance tumorigenesis by suppressing tumor cell senescence. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Oct 2011].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| NIMA related kinase 6 | MIM:604884 | Ensembl:ENSG00000119408 | HGNC:HGNC:7749 | PA31550 | 9q33.3 |
GO terms in NEK6
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IDA | GO:0000287 | magnesium ion binding |
| MF | IPI | GO:0001222 | transcription corepressor binding |
| MF | IDA | GO:0004674 | protein serine/threonine kinase activity |
| MF | TAS | GO:0004674 | protein serine/threonine kinase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IDA | GO:0005524 | ATP binding |
| MF | IPI | GO:0019894 | kinesin binding |
| MF | IPI | GO:0019901 | protein kinase binding |
| MF | IPI | GO:0031625 | ubiquitin protein ligase binding |
| MF | IPI | GO:0033613 | activating transcription factor binding |
| BP | IDA | GO:0006468 | protein phosphorylation |
| BP | IEA | GO:0006915 | apoptotic process |
| BP | IDA | GO:0007059 | chromosome segregation |
| BP | TAS | GO:0007077 | mitotic nuclear envelope disassembly |
| BP | TAS | GO:0007346 | regulation of mitotic cell cycle |
| BP | IDA | GO:0018105 | peptidyl-serine phosphorylation |
| BP | IDA | GO:0030071 | regulation of mitotic metaphase/anaphase transition |
| BP | HMP | GO:0043123 | positive regulation of I-kappaB kinase/NF-kappaB signaling |
| BP | IDA | GO:0046777 | protein autophosphorylation |
| BP | TAS | GO:0051225 | spindle assembly |
| BP | IEA | GO:0051301 | cell division |
| BP | TAS | GO:2000772 | regulation of cellular senescence |
| CC | IEA | GO:0000922 | spindle pole |
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005813 | centrosome |
| CC | IDA | GO:0005815 | microtubule organizing center |
| CC | IDA | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| CC | IEA | GO:0005874 | microtubule |
| CC | IEA | GO:0016607 | nuclear speck |
| CC | IDA | GO:0032991 | protein-containing complex |
| CC | IDA | GO:0043231 | intracellular membrane-bounded organelle |
Gene expression in normal tissue: NEK6
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in NEK6
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1640170 | Cell Cycle |
| reactome | R-HSA-2980766 | Nuclear Envelope Breakdown |
| reactome | R-HSA-2980767 | Activation of NIMA Kinases NEK9, NEK6, NEK7 |
| reactome | R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly |
| reactome | R-HSA-68875 | Mitotic Prophase |
| reactome | R-HSA-68886 | M Phase |
| reactome | R-HSA-69278 | Cell Cycle, Mitotic |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD802 | 4-methylfasudil | 6 |
| iGMDRD137 | Indisulam | 4 |
| iGMDRD405 | PIK-75 | 3 |
| iGMDRD294 | Batimastat | 2 |
| iGMDRD506 | Fedratinib | 1 |
| iGMDRD351 | GW843682X | 3 |
| iGMDRD329 | Merck60 | 5 |
| iGMDRD193 | Fqi1 | 3 |
| iGMDRD871 | BRD6368 | 3 |
| iGMDRD74 | Idarubicin | 3 |
| iGMDRD451 | Serdemetan | 3 |
| iGMDRD901 | ELCPK | 3 |
| iGMDRD280 | CYTOCHALASIN B | 3 |
| iGMDRD64 | Parbendazole | 3 |
| iGMDRD123 | Isoevodiamine | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in NEK6
CLASSFICATION
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