TCF12
Summary: The protein encoded by this gene is a member of the basic helix-loop-helix (bHLH) E-protein family that recognizes the consensus binding site (E-box) CANNTG. This encoded protein is expressed in many tissues, among them skeletal muscle, thymus, B- and T-cells, and may participate in regulating lineage-specific gene expression through the formation of heterodimers with other bHLH E-proteins. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| transcription factor 12 | MIM:600480 | Ensembl:ENSG00000140262 | HGNC:HGNC:11623 | PA36381 | 15q21.3 |
GO terms in TCF12
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IDA | GO:0000790 | nuclear chromatin |
| CC | IBA | GO:0005634 | nucleus |
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IBA | GO:0005667 | transcription factor complex |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0016607 | nuclear speck |
| CC | IDA | GO:0043231 | intracellular membrane-bounded organelle |
| CC | IDA | GO:0090575 | RNA polymerase II transcription factor complex |
| BP | TAS | GO:0006357 | regulation of transcription by RNA polymerase II |
| BP | IEA | GO:0006366 | transcription by RNA polymerase II |
| BP | TAS | GO:0006955 | immune response |
| BP | TAS | GO:0007517 | muscle organ development |
| BP | IBA | GO:0045666 | positive regulation of neuron differentiation |
| BP | IBA | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IDA | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | TAS | GO:1902036 | regulation of hematopoietic stem cell differentiation |
| MF | IBA | GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding |
| MF | IDA | GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding |
| MF | ISA | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | ISM | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | NAS | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | IDA | GO:0001077 | transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding |
| MF | IBA | GO:0003700 | DNA-binding transcription factor activity |
| MF | IDA | GO:0003700 | DNA-binding transcription factor activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IPI | GO:0008134 | transcription factor binding |
| MF | IC | GO:0035326 | enhancer binding |
| MF | IEA | GO:0035497 | cAMP response element binding |
| MF | IBA | GO:0042803 | protein homodimerization activity |
| MF | IBA | GO:0043425 | bHLH transcription factor binding |
| MF | IPI | GO:0043425 | bHLH transcription factor binding |
| MF | IDA | GO:0044212 | transcription regulatory region DNA binding |
| MF | IPI | GO:0046332 | SMAD binding |
| MF | IBA | GO:0046982 | protein heterodimerization activity |
| MF | IEA | GO:0070888 | E-box binding |
| MF | IEA | GO:0071837 | HMG box domain binding |
Gene expression in normal tissue: TCF12
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in TCF12
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-212436 | Generic Transcription Pathway |
| reactome | R-HSA-375170 | CDO in myogenesis |
| reactome | R-HSA-375170 | CDO in myogenesis |
| reactome | R-HSA-525793 | Myogenesis |
| reactome | R-HSA-525793 | Myogenesis |
| reactome | R-HSA-73857 | RNA Polymerase II Transcription |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| reactome | R-HSA-8878171 | Transcriptional regulation by RUNX1 |
| reactome | R-HSA-8939236 | RUNX1 regulates transcription of genes involved in differentiation of HSCs |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD870 | BRD63610 | 1 |
| iGMDRD513 | BML-259 | 1 |
| iGMDRD138 | PX 12 | 2 |
| iGMDRD255 | SB225002 | 2 |
| iGMDRD690 | PRIMA-1MET | 2 |
| iGMDRD64 | Parbendazole | 2 |
| iGMDRD356 | PNU-74654 | 2 |
| iGMDRD100 | Zebularine | 2 |
| iGMDRD188 | Piperlongumine | 4 |
| iGMDRD887 | Compound 23 citrate | 2 |
| iGMDRD74 | Idarubicin | 2 |
| iGMDRD398 | Sepantronium | 3 |
| iGMDRD781 | Sirolimus | 3 |
| iGMDRD126 | Tipifarnib | 4 |
| iGMDRD772 | BRD4770 | 3 |
| iGMDRD679 | Bistramide A | 1 |
| iGMDRD466 | Chaetocin | 3 |
| iGMDRD634 | SCHEMBL2608041 | 3 |
| iGMDRD61 | Kinetin riboside | 2 |
| iGMDRD289 | Parthenolide | 5 |
| iGMDRD434 | BMS-536924 | 3 |
| iGMDRD77 | Itraconazole | 5 |
| iGMDRD121 | GMX1778 | 2 |
| iGMDRD147 | Prima-1 | 2 |
| iGMDRD246 | NPC26 | 3 |
| iGMDRD42 | Vorinostat | 2 |
| iGMDRD322 | FK 866 | 4 |
| iGMDRD286 | Nsc 632839 | 4 |
| iGMDRD150 | RITA | 7 |
| iGMDRD148 | Pifithrin-mu | 2 |
| iGMDRD123 | Isoevodiamine | 3 |
| iGMDRD945 | ML214 | 3 |
| iGMDRD351 | GW843682X | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in TCF12
CLASSFICATION
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