STK38

Summary: This gene encodes a member of the AGC serine/threonine kinase family of proteins. The kinase activity of this protein is regulated by autophosphorylation and phosphorylation by other upstream kinases. This protein has been shown to function in the cell cycle and apoptosis. This protein has also been found to regulate the protein stability and transcriptional activity of the MYC oncogene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Nameserine/threonine kinase 38
OMIM IDMIM:606964
Ensembl IDEnsembl:ENSG00000112079
HGNC IDHGNC:HGNC:17847
PHARMGKB IDPA38251
Map Location6p21.31

GO terms in STK38


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Term Type
Evidence Type
GO Term ID
GO Des.
BP IDA GO:0006464 cellular protein modification process
BP IDA GO:0006468 protein phosphorylation
BP IBA GO:0018105 peptidyl-serine phosphorylation
BP IBA GO:0035556 intracellular signal transduction
BP IDA GO:0035556 intracellular signal transduction
BP IDA GO:0043407 negative regulation of MAP kinase activity
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Gene expression in normal tissue: STK38

16 tissues mixtureadiposeadrenalbrainbreastcolonheartkidneyliverlunglymph nodeovaryprostateskeletal muscletestesthyroidwhite blood cells

Gene-model tissue-cancer distribution: Bubble Plot

undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 38BOWEtissue: BOWE cancer: BOWEL model num: 0BOWELtissue: BOWEL cancer: undefined model num: 13

Gene-drug pathway distribution

undefined14Apoptosis regulation1Chromatin other1DNA replication1ERK MAPK signaling1One carbon pool by folate1

Pathways in STK38


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Database
Pathway ID
Pathway Des.
wikipathways WP2916 Interactome of polycomb repressive complex 2 (PRC2)
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD427 ABT737 3
iGMDRD85 Ursolic acid 1
iGMDRD536 PLX-4720 1
iGMDRD280 CYTOCHALASIN B 5
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in STK38

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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