CARD11
Summary: The protein encoded by this gene belongs to the membrane-associated guanylate kinase (MAGUK) family, a class of proteins that functions as molecular scaffolds for the assembly of multiprotein complexes at specialized regions of the plasma membrane. This protein is also a member of the CARD protein family, which is defined by carrying a characteristic caspase-associated recruitment domain (CARD). This protein has a domain structure similar to that of CARD14 protein. The CARD domains of both proteins have been shown to specifically interact with BCL10, a protein known to function as a positive regulator of cell apoptosis and NF-kappaB activation. When expressed in cells, this protein activated NF-kappaB and induced the phosphorylation of BCL10. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| caspase recruitment domain family member 11 | MIM:607210 | Ensembl:ENSG00000198286 | HGNC:HGNC:16393 | PA26073 | 7p22.2 |
GO terms in CARD11
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IMP | GO:0001819 | positive regulation of cytokine production |
| BP | TAS | GO:0002223 | stimulatory C-type lectin receptor signaling pathway |
| BP | IEA | GO:0002377 | immunoglobulin production |
| BP | IMP | GO:0007249 | I-kappaB kinase/NF-kappaB signaling |
| BP | IEA | GO:0030183 | B cell differentiation |
| BP | IEA | GO:0030890 | positive regulation of B cell proliferation |
| BP | IDA | GO:0031295 | T cell costimulation |
| BP | TAS | GO:0038095 | Fc-epsilon receptor signaling pathway |
| BP | IMP | GO:0038202 | TORC1 signaling |
| BP | IEA | GO:0042100 | B cell proliferation |
| BP | IEA | GO:0042102 | positive regulation of T cell proliferation |
| BP | IEA | GO:0042981 | regulation of apoptotic process |
| BP | IEA | GO:0043123 | positive regulation of I-kappaB kinase/NF-kappaB signaling |
| BP | IEA | GO:0045061 | thymic T cell selection |
| BP | IEA | GO:0045086 | positive regulation of interleukin-2 biosynthetic process |
| BP | IEA | GO:0045577 | regulation of B cell differentiation |
| BP | IEA | GO:0045580 | regulation of T cell differentiation |
| BP | IEA | GO:0046037 | GMP metabolic process |
| BP | IEA | GO:0046710 | GDP metabolic process |
| BP | IEA | GO:0048872 | homeostasis of number of cells |
| BP | TAS | GO:0050852 | T cell receptor signaling pathway |
| BP | IMP | GO:0051092 | positive regulation of NF-kappaB transcription factor activity |
| BP | IEA | GO:0070970 | interleukin-2 secretion |
| CC | IEA | GO:0001772 | immunological synapse |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | TAS | GO:0005829 | cytosol |
| CC | IDA | GO:0005886 | plasma membrane |
| CC | TAS | GO:0005886 | plasma membrane |
| CC | IDA | GO:0032449 | CBM complex |
| CC | IDA | GO:0042101 | T cell receptor complex |
| CC | IDA | GO:0045121 | membrane raft |
| CC | HDA | GO:0070062 | extracellular exosome |
| MF | NAS | GO:0004385 | guanylate kinase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IPI | GO:0050700 | CARD domain binding |
Gene expression in normal tissue: CARD11
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CARD11
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| reactome | R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) |
| reactome | R-HSA-1168372 | Downstream signaling events of B Cell Receptor (BCR) |
| reactome | R-HSA-1169091 | Activation of NF-kappaB in B cells |
| reactome | R-HSA-1169091 | Activation of NF-kappaB in B cells |
| reactome | R-HSA-1280218 | Adaptive Immune System |
| reactome | R-HSA-1280218 | Adaptive Immune System |
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168249 | Innate Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-202403 | TCR signaling |
| reactome | R-HSA-202424 | Downstream TCR signaling |
| reactome | R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling |
| reactome | R-HSA-2454202 | Fc epsilon receptor (FCERI) signaling |
| reactome | R-HSA-2871837 | FCERI mediated NF-kB activation |
| reactome | R-HSA-2871837 | FCERI mediated NF-kB activation |
| reactome | R-HSA-5607764 | CLEC7A (Dectin-1) signaling |
| reactome | R-HSA-5621481 | C-type lectin receptors (CLRs) |
| reactome | R-HSA-983705 | Signaling by the B Cell Receptor (BCR) |
| reactome | R-HSA-983705 | Signaling by the B Cell Receptor (BCR) |
| wikipathways | WP23 | B Cell Receptor Signaling Pathway |
| wikipathways | WP3863 | T-Cell antigen Receptor (TCR) pathway during Staphylococcus aureus infection |
| wikipathways | WP69 | T-Cell antigen Receptor (TCR) Signaling Pathway |
| pid | bcr_5pathway | BCR signaling pathway |
| pid | cd8tcrpathway | TCR signaling in naïve CD8+ T cells |
| pid | tcr_pathway | TCR signaling in naïve CD4+ T cells |
| netpath | Pathway_BCR | BCR |
| netpath | Pathway_TCR | TCR |
| kegg | hsa04064 | NF-kappa B signaling pathway - Homo sapiens (human) |
| kegg | hsa04660 | T cell receptor signaling pathway - Homo sapiens (human) |
| kegg | hsa04662 | B cell receptor signaling pathway - Homo sapiens (human) |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD52 | Rotenone | 1 |
| iGMDRD289 | Parthenolide | 3 |
| iGMDRD434 | BMS-536924 | 6 |
| iGMDRD5 | Tyrphostin AG 1478 | 3 |
| iGMDRD255 | SB225002 | 3 |
| iGMDRD886 | Compound 1541A | 3 |
| iGMDRD300 | Tozasertib | 3 |
| iGMDRD60 | Quinoclamine | 3 |
| iGMDRD329 | Merck60 | 6 |
| iGMDRD562 | Navitoclax | 3 |
| iGMDRD188 | Piperlongumine | 4 |
| iGMDRD414 | MST-312 | 3 |
| iGMDRD74 | Idarubicin | 2 |
| iGMDRD887 | Compound 23 citrate | 5 |
| iGMDRD150 | RITA | 3 |
| iGMDRD424 | Tamatinib | 2 |
| iGMDRD546 | BMS-754807 | 2 |
| iGMDRD670 | ML 210 | 3 |
| iGMDRD144 | NSC95397 | 5 |
| iGMDRD772 | BRD4770 | 2 |
| iGMDRD248 | BRD4354 | 1 |
| iGMDRD48 | Dexamethasone | 3 |
| iGMDRD126 | Tipifarnib | 4 |
| iGMDRD634 | SCHEMBL2608041 | 5 |
| iGMDRD132 | (-)-gallocatechin-3-O-gallate | 3 |
| iGMDRD945 | ML214 | 3 |
| iGMDRD211 | (1S,3R)-RSL3 | 3 |
| iGMDRD901 | ELCPK | 1 |
| iGMDRD394 | BX-795 | 3 |
| iGMDRD351 | GW843682X | 6 |
| iGMDRD201 | SKI II | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CARD11
CLASSFICATION
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