CACNB2


Summary: This gene encodes a subunit of a voltage-dependent calcium channel protein that is a member of the voltage-gated calcium channel superfamily. The gene product was originally identified as an antigen target in Lambert-Eaton myasthenic syndrome, an autoimmune disorder. Mutations in this gene are associated with Brugada syndrome. Alternatively spliced variants encoding different isoforms have been described. [provided by RefSeq, Feb 2013].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
calcium voltage-gated channel auxiliary subunit beta 2MIM:600003Ensembl:ENSG00000165995HGNC:HGNC:1402PA8810p12.33-p12.31

GO terms in CACNB2


Term TypeEvidence TypeGO Term IDGO Des.
CCTASGO:0005886plasma membrane
CCNASGO:0005887integral component of plasma membrane
CCIBAGO:0005891voltage-gated calcium channel complex
CCIDAGO:0005891voltage-gated calcium channel complex
CCIDAGO:1990454L-type voltage-gated calcium channel complex
BPIBAGO:0007268chemical synaptic transmission
BPIBAGO:0007528neuromuscular junction development
BPTASGO:0007528neuromuscular junction development
BPIEAGO:0007601visual perception
BPIDAGO:0051928positive regulation of calcium ion transport
BPIDAGO:0070509calcium ion import
BPIEAGO:0070588calcium ion transmembrane transport
BPISSGO:0072659protein localization to plasma membrane
BPIMPGO:0086045membrane depolarization during AV node cell action potential
BPIMPGO:0086091regulation of heart rate by cardiac conduction
BPIMPGO:0098912membrane depolarization during atrial cardiac muscle cell action potential
BPIBAGO:1901385regulation of voltage-gated calcium channel activity
BPISSGO:1901843positive regulation of high voltage-gated calcium channel activity
BPISSGO:1904879positive regulation of calcium ion transmembrane transport via high voltage-gated calcium channel
MFIDAGO:0005245voltage-gated calcium channel activity
MFNASGO:0005262calcium channel activity
MFIPIGO:0005515protein binding
MFIBAGO:0008331high voltage-gated calcium channel activity
MFIDAGO:0008331high voltage-gated calcium channel activity
MFISSGO:0051015actin filament binding
MFIMPGO:0086007voltage-gated calcium channel activity involved in cardiac muscle cell action potential
MFIMPGO:0086056voltage-gated calcium channel activity involved in AV node cell action potential

Gene expression in normal tissue: CACNB2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in CACNB2


DatabasePathway IDPathway Des.
kegghsa04010MAPK signaling pathway - Homo sapiens (human)
kegghsa04260Cardiac muscle contraction - Homo sapiens (human)
kegghsa04261Adrenergic signaling in cardiomyocytes - Homo sapiens (human)
kegghsa04921Oxytocin signaling pathway - Homo sapiens (human)
kegghsa05410Hypertrophic cardiomyopathy (HCM) - Homo sapiens (human)
kegghsa05412Arrhythmogenic right ventricular cardiomyopathy (ARVC) - Homo sapiens (human)
kegghsa05414Dilated cardiomyopathy (DCM) - Homo sapiens (human)
pharmgkbPA152241951Celecoxib Pathway, Pharmacodynamics
pharmgkbPA2033Antiarrhythmic Pathway, Pharmacodynamics
wikipathwaysWP2118Arrhythmogenic Right Ventricular Cardiomyopathy
wikipathwaysWP382MAPK Signaling Pathway
reactomeR-HSA-112308Presynaptic depolarization and calcium channel opening
reactomeR-HSA-112315Transmission across Chemical Synapses
reactomeR-HSA-112316Neuronal System
reactomeR-HSA-1266738Developmental Biology
reactomeR-HSA-1430728Metabolism
reactomeR-HSA-1430728Metabolism
reactomeR-HSA-163685Integration of energy metabolism
reactomeR-HSA-163685Integration of energy metabolism
reactomeR-HSA-375165NCAM signaling for neurite out-growth
reactomeR-HSA-397014Muscle contraction
reactomeR-HSA-400042Adrenaline,noradrenaline inhibits insulin secretion
reactomeR-HSA-419037NCAM1 interactions
reactomeR-HSA-422356Regulation of insulin secretion
reactomeR-HSA-422356Regulation of insulin secretion
reactomeR-HSA-422475Axon guidance
reactomeR-HSA-5576891Cardiac conduction
reactomeR-HSA-5576892Phase 0 - rapid depolarisation
reactomeR-HSA-5576893Phase 2 - plateau phase

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD280CYTOCHALASIN B5
iGMDRD446LY 218324010
iGMDRD61Kinetin riboside2
iGMDRD193Fqi13
iGMDRD639YK 4-2793
iGMDRD781Sirolimus7
iGMDRD433Lexibulin3
iGMDRD151CHM-12
iGMDRD126Tipifarnib8
iGMDRD772BRD47702
iGMDRD889Compound 7d-cis3
iGMDRD60Quinoclamine3
iGMDRD64Parbendazole3
iGMDRD690PRIMA-1MET2
iGMDRD444Tivantinib2
iGMDRD451Serdemetan2
iGMDRD524ISX-92
iGMDRD23Gossypol2
iGMDRD356PNU-746541
iGMDRD399Selumetinib2
iGMDRD730Kahalalide F3
iGMDRD74Idarubicin3
iGMDRD188Piperlongumine6
iGMDRD100Zebularine5
iGMDRD780PP-302
iGMDRD506Fedratinib5
iGMDRD171Pemetrexed2
iGMDRD187BRD98764
iGMDRD870BRD636103
iGMDRD8012,4-dideoxy-DC-45-A22
iGMDRD138PX 122
iGMDRD255SB2250025
iGMDRD8024-methylfasudil5
iGMDRD123Isoevodiamine5
iGMDRD177Teniposide3
iGMDRD901ELCPK1
iGMDRD945ML2142
iGMDRD85Ursolic acid2
iGMDRD341Triacsin c3
iGMDRD57Chloropentafluorobenzene3
iGMDRD424Tamatinib2
iGMDRD532Olaparib3
iGMDRD701NVP-AUY9221
iGMDRD79Gemcitabine2
iGMDRD307Manumycin A2
iGMDRD84Lovastatin acid2
iGMDRD512nutlin 33
iGMDRD300Tozasertib2
iGMDRD505Pevonedistat3
iGMDRD353PD03259011
iGMDRD872BRD71375
iGMDRD882CIL412
iGMDRD367Ro 28-16752
iGMDRD286Nsc 6328392
iGMDRD871BRD63685
iGMDRD289Parthenolide2
iGMDRD481Dactolisib2
iGMDRD158NSC1415402
iGMDRD202Curcumin4
iGMDRD137Indisulam2

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in CACNB2

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