CACNB2

Summary: This gene encodes a subunit of a voltage-dependent calcium channel protein that is a member of the voltage-gated calcium channel superfamily. The gene product was originally identified as an antigen target in Lambert-Eaton myasthenic syndrome, an autoimmune disorder. Mutations in this gene are associated with Brugada syndrome. Alternatively spliced variants encoding different isoforms have been described. [provided by RefSeq, Feb 2013].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Namecalcium voltage-gated channel auxiliary subunit beta 2
OMIM IDMIM:600003
Ensembl IDEnsembl:ENSG00000165995
HGNC IDHGNC:HGNC:1402
PHARMGKB IDPA88
Map Location10p12.33-p12.31

GO terms in CACNB2


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Term Type
Evidence Type
GO Term ID
GO Des.
CC TAS GO:0005886 plasma membrane
CC NAS GO:0005887 integral component of plasma membrane
CC IBA GO:0005891 voltage-gated calcium channel complex
CC IDA GO:0005891 voltage-gated calcium channel complex
CC IDA GO:1990454 L-type voltage-gated calcium channel complex
BP IBA GO:0007268 chemical synaptic transmission
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Gene expression in normal tissue: CACNB2

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

undefined44ERK MAPK signaling2Mitosis1Purine metabolism1Chromatin histone acetylation1Stilbenoid, diarylheptanoid and gingerol biosynthesis1DNA replication1PI3K/MTOR signaling1Protein stability and degradation1One carbon pool by folate1

Pathways in CACNB2


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Database
Pathway ID
Pathway Des.
kegg hsa04010 MAPK signaling pathway - Homo sapiens (human)
kegg hsa04260 Cardiac muscle contraction - Homo sapiens (human)
kegg hsa04261 Adrenergic signaling in cardiomyocytes - Homo sapiens (human)
kegg hsa04921 Oxytocin signaling pathway - Homo sapiens (human)
kegg hsa05410 Hypertrophic cardiomyopathy (HCM) - Homo sapiens (human)
kegg hsa05412 Arrhythmogenic right ventricular cardiomyopathy (ARVC) - Homo sapiens (human)
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD280 CYTOCHALASIN B 5
iGMDRD446 LY 2183240 10
iGMDRD61 Kinetin riboside 2
iGMDRD193 Fqi1 3
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in CACNB2

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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