LPP
Summary: This gene encodes a member of a subfamily of LIM domain proteins that are characterized by an N-terminal proline-rich region and three C-terminal LIM domains. The encoded protein localizes to the cell periphery in focal adhesions and may be involved in cell-cell adhesion and cell motility. This protein also shuttles through the nucleus and may function as a transcriptional co-activator. This gene is located at the junction of certain disease-related chromosomal translocations, which result in the expression of chimeric proteins that may promote tumor growth. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| LIM domain containing preferred translocation partner in lipoma | MIM:600700 | Ensembl:ENSG00000145012 | HGNC:HGNC:6679 | PA30440 | 3q27.3-q28 |
GO terms in LPP
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0046872 | metal ion binding |
| CC | IEA | GO:0005634 | nucleus |
| CC | IDA | GO:0005829 | cytosol |
| CC | IEA | GO:0005886 | plasma membrane |
| CC | HDA | GO:0005925 | focal adhesion |
| CC | IDA | GO:0005925 | focal adhesion |
| BP | IEA | GO:0007155 | cell adhesion |
| BP | ND | GO:0008150 | biological_process |
Gene expression in normal tissue: LPP
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in LPP
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| pid | ecadherin_stabilization_pathway | Stabilization and expansion of the E-cadherin adherens junction |
| netpath | Pathway_EGFR1 | EGFR1 |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD177 | Teniposide | 5 |
| iGMDRD123 | Isoevodiamine | 3 |
| iGMDRD211 | (1S,3R)-RSL3 | 3 |
| iGMDRD154 | NSC23766 | 6 |
| iGMDRD511 | CHEMBL399379 | 2 |
| iGMDRD49 | Mitomycin | 2 |
| iGMDRD314 | Tanespimycin | 3 |
| iGMDRD57 | Chloropentafluorobenzene | 1 |
| iGMDRD79 | Gemcitabine | 5 |
| iGMDRD405 | PIK-75 | 4 |
| iGMDRD701 | NVP-AUY922 | 5 |
| iGMDRD523 | Cyanoquinoline, 11 | 1 |
| iGMDRD330 | BRD4132 | 3 |
| iGMDRD584 | VER 155008 | 2 |
| iGMDRD512 | nutlin 3 | 3 |
| iGMDRD300 | Tozasertib | 11 |
| iGMDRD82 | Quiflapon | 3 |
| iGMDRD414 | MST-312 | 5 |
| iGMDRD286 | Nsc 632839 | 6 |
| iGMDRD367 | Ro 28-1675 | 3 |
| iGMDRD329 | Merck60 | 3 |
| iGMDRD434 | BMS-536924 | 2 |
| iGMDRD705 | Nakiterpiosin | 2 |
| iGMDRD6 | AM-580 | 3 |
| iGMDRD77 | Itraconazole | 2 |
| iGMDRD158 | NSC141540 | 3 |
| iGMDRD271 | Brefeldin A | 5 |
| iGMDRD103 | SN-38 | 6 |
| iGMDRD280 | CYTOCHALASIN B | 6 |
| iGMDRD297 | Austocystin D | 2 |
| iGMDRD375 | GW-405833 | 1 |
| iGMDRD634 | SCHEMBL2608041 | 1 |
| iGMDRD546 | BMS-754807 | 1 |
| iGMDRD670 | ML 210 | 3 |
| iGMDRD427 | ABT737 | 5 |
| iGMDRD781 | Sirolimus | 1 |
| iGMDRD484 | Pluripotin | 6 |
| iGMDRD494 | Neopeltolide | 1 |
| iGMDRD483 | SCH-529074 | 1 |
| iGMDRD554 | CHEMBL1434137 | 3 |
| iGMDRD420 | Leucascandrolide A | 2 |
| iGMDRD599 | Salermide | 3 |
| iGMDRD451 | Serdemetan | 2 |
| iGMDRD74 | Idarubicin | 4 |
| iGMDRD887 | Compound 23 citrate | 1 |
| iGMDRD888 | Compound 44 | 3 |
| iGMDRD52 | Rotenone | 3 |
| iGMDRD318 | PAC-1 | 1 |
| iGMDRD802 | 4-methylfasudil | 5 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in LPP
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