TAL2
Summary: This intronless gene encodes a helix-loop-helix protein. Translocations between this gene on chromosome 9 and the T-cell receptor beta-chain locus on chromosome 7 have been associated with activation of the T-cell acute lymphocytic leukemia 2 gene and T-cell acute lymphoblastic leukemia. [provided by RefSeq, Mar 2009].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| TAL bHLH transcription factor 2 | MIM:186855 | Ensembl:ENSG00000186051 | HGNC:HGNC:11557 | PA36327 | 9q31.2 |
GO terms in TAL2
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IBA | GO:0005634 | nucleus |
| BP | IEA | GO:0006351 | transcription, DNA-templated |
| BP | IBA | GO:0006357 | regulation of transcription by RNA polymerase II |
| BP | IEA | GO:0006357 | regulation of transcription by RNA polymerase II |
| BP | IEA | GO:0009791 | post-embryonic development |
| BP | IEA | GO:0021794 | thalamus development |
| BP | IEA | GO:0030901 | midbrain development |
| BP | IEA | GO:0035264 | multicellular organism growth |
| MF | IBA | GO:0000977 | RNA polymerase II regulatory region sequence-specific DNA binding |
| MF | IBA | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | ISA | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | ISM | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | TAS | GO:0003677 | DNA binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0046983 | protein dimerization activity |
Gene expression in normal tissue: TAL2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in TAL2
| Database | Pathway ID | Pathway Des. |
|---|
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD171 | Pemetrexed | 1 |
| iGMDRD801 | 2,4-dideoxy-DC-45-A2 | 3 |
| iGMDRD187 | BRD9876 | 2 |
| iGMDRD294 | Batimastat | 3 |
| iGMDRD137 | Indisulam | 6 |
| iGMDRD158 | NSC141540 | 6 |
| iGMDRD802 | 4-methylfasudil | 3 |
| iGMDRD451 | Serdemetan | 5 |
| iGMDRD74 | Idarubicin | 5 |
| iGMDRD887 | Compound 23 citrate | 2 |
| iGMDRD405 | PIK-75 | 3 |
| iGMDRD512 | nutlin 3 | 3 |
| iGMDRD177 | Teniposide | 1 |
| iGMDRD375 | GW-405833 | 3 |
| iGMDRD154 | NSC23766 | 6 |
| iGMDRD314 | Tanespimycin | 5 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in TAL2
CLASSFICATION
Copyright © 2018 Modellab | All Rights Reserved
Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.