FLNB


Summary: This gene encodes a member of the filamin family. The encoded protein interacts with glycoprotein Ib alpha as part of the process to repair vascular injuries. The platelet glycoprotein Ib complex includes glycoprotein Ib alpha, and it binds the actin cytoskeleton. Mutations in this gene have been found in several conditions: atelosteogenesis type 1 and type 3; boomerang dysplasia; autosomal dominant Larsen syndrome; and spondylocarpotarsal synostosis syndrome. Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Nov 2009].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
filamin BMIM:603381Ensembl:ENSG00000136068HGNC:HGNC:3755PA281733p14.3

GO terms in FLNB


Term TypeEvidence TypeGO Term IDGO Des.
CCIEAGO:0001725stress fiber
CCHDAGO:0005737cytoplasm
CCIDAGO:0005829cytosol
CCTASGO:0005829cytosol
CCIDAGO:0005886plasma membrane
CCIEAGO:0005903brush border
CCHDAGO:0005925focal adhesion
CCIEAGO:0005938cell cortex
CCTASGO:0015629actin cytoskeleton
CCNASGO:0016021integral component of membrane
CCIEAGO:0030018Z disc
CCIEAGO:0045335phagocytic vesicle
CCHDAGO:0070062extracellular exosome
BPIEAGO:0003334keratinocyte development
BPIEAGO:0003382epithelial cell morphogenesis
BPTASGO:0007016cytoskeletal anchoring at plasma membrane
BPTASGO:0007165signal transduction
BPIEAGO:0007519skeletal muscle tissue development
BPIEAGO:0030036actin cytoskeleton organization
BPIEAGO:0071346cellular response to interferon-gamma
MFHDAGO:0003723RNA binding
MFNASGO:0003779actin binding
MFIPIGO:0005515protein binding
MFIPIGO:0042802identical protein binding
MFHDAGO:0045296cadherin binding

Gene expression in normal tissue: FLNB

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in FLNB


DatabasePathway IDPathway Des.
wikipathwaysWP306Focal Adhesion
wikipathwaysWP382MAPK Signaling Pathway
wikipathwaysWP3888VEGFA-VEGFR2 Signaling Pathway
kegghsa04010MAPK signaling pathway - Homo sapiens (human)
kegghsa04510Focal adhesion - Homo sapiens (human)
kegghsa05132Salmonella infection - Homo sapiens (human)
kegghsa05205Proteoglycans in cancer - Homo sapiens (human)
netpathPathway_EGFR1EGFR1
netpathPathway_TCRTCR
reactomeR-HSA-1169408ISG15 antiviral mechanism
reactomeR-HSA-1169410Antiviral mechanism by IFN-stimulated genes
reactomeR-HSA-1280215Cytokine Signaling in Immune system
reactomeR-HSA-168256Immune System
reactomeR-HSA-913531Interferon Signaling

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD662JQ-12
iGMDRD286Nsc 6328397
iGMDRD414MST-3126
iGMDRD871BRD63683
iGMDRD322FK 8661
iGMDRD263AACOCF31
iGMDRD147Prima-12
iGMDRD271Brefeldin A5
iGMDRD251ML1621
iGMDRD158NSC1415402
iGMDRD137Indisulam3
iGMDRD103SN-386
iGMDRD434BMS-5369244
iGMDRD105Triptolide3
iGMDRD289Parthenolide3
iGMDRD6AM-5802
iGMDRD49Mitomycin3
iGMDRD945ML2143
iGMDRD248BRD43544
iGMDRD330BRD41325
iGMDRD84Lovastatin acid3
iGMDRD701NVP-AUY9222
iGMDRD424Tamatinib5
iGMDRD116CD4377
iGMDRD150RITA5
iGMDRD888Compound 445
iGMDRD506Fedratinib2
iGMDRD74Idarubicin2
iGMDRD188Piperlongumine6
iGMDRD23Gossypol4
iGMDRD255SB2250021
iGMDRD260FQI-22
iGMDRD138PX 125
iGMDRD480KU00606482
iGMDRD870BRD636101
iGMDRD318PAC-13
iGMDRD226ML0062
iGMDRD782DC-45-A23
iGMDRD152179324-69-71
iGMDRD446LY 21832405
iGMDRD634SCHEMBL26080413
iGMDRD280CYTOCHALASIN B1
iGMDRD297Austocystin D3
iGMDRD425ERASTIN3
iGMDRD772BRD47702
iGMDRD210AC556493
iGMDRD151CHM-11
iGMDRD554CHEMBL14341374
iGMDRD433Lexibulin3
iGMDRD781Sirolimus3
iGMDRD144NSC953976
iGMDRD546BMS-7548072

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in FLNB

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