FLNB
Summary: This gene encodes a member of the filamin family. The encoded protein interacts with glycoprotein Ib alpha as part of the process to repair vascular injuries. The platelet glycoprotein Ib complex includes glycoprotein Ib alpha, and it binds the actin cytoskeleton. Mutations in this gene have been found in several conditions: atelosteogenesis type 1 and type 3; boomerang dysplasia; autosomal dominant Larsen syndrome; and spondylocarpotarsal synostosis syndrome. Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene. [provided by RefSeq, Nov 2009].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| filamin B | MIM:603381 | Ensembl:ENSG00000136068 | HGNC:HGNC:3755 | PA28173 | 3p14.3 |
GO terms in FLNB
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IEA | GO:0001725 | stress fiber |
| CC | HDA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| CC | IDA | GO:0005886 | plasma membrane |
| CC | IEA | GO:0005903 | brush border |
| CC | HDA | GO:0005925 | focal adhesion |
| CC | IEA | GO:0005938 | cell cortex |
| CC | TAS | GO:0015629 | actin cytoskeleton |
| CC | NAS | GO:0016021 | integral component of membrane |
| CC | IEA | GO:0030018 | Z disc |
| CC | IEA | GO:0045335 | phagocytic vesicle |
| CC | HDA | GO:0070062 | extracellular exosome |
| BP | IEA | GO:0003334 | keratinocyte development |
| BP | IEA | GO:0003382 | epithelial cell morphogenesis |
| BP | TAS | GO:0007016 | cytoskeletal anchoring at plasma membrane |
| BP | TAS | GO:0007165 | signal transduction |
| BP | IEA | GO:0007519 | skeletal muscle tissue development |
| BP | IEA | GO:0030036 | actin cytoskeleton organization |
| BP | IEA | GO:0071346 | cellular response to interferon-gamma |
| MF | HDA | GO:0003723 | RNA binding |
| MF | NAS | GO:0003779 | actin binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IPI | GO:0042802 | identical protein binding |
| MF | HDA | GO:0045296 | cadherin binding |
Gene expression in normal tissue: FLNB
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in FLNB
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP306 | Focal Adhesion |
| wikipathways | WP382 | MAPK Signaling Pathway |
| wikipathways | WP3888 | VEGFA-VEGFR2 Signaling Pathway |
| kegg | hsa04010 | MAPK signaling pathway - Homo sapiens (human) |
| kegg | hsa04510 | Focal adhesion - Homo sapiens (human) |
| kegg | hsa05132 | Salmonella infection - Homo sapiens (human) |
| kegg | hsa05205 | Proteoglycans in cancer - Homo sapiens (human) |
| netpath | Pathway_EGFR1 | EGFR1 |
| netpath | Pathway_TCR | TCR |
| reactome | R-HSA-1169408 | ISG15 antiviral mechanism |
| reactome | R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes |
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-913531 | Interferon Signaling |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD662 | JQ-1 | 2 |
| iGMDRD286 | Nsc 632839 | 7 |
| iGMDRD414 | MST-312 | 6 |
| iGMDRD871 | BRD6368 | 3 |
| iGMDRD322 | FK 866 | 1 |
| iGMDRD263 | AACOCF3 | 1 |
| iGMDRD147 | Prima-1 | 2 |
| iGMDRD271 | Brefeldin A | 5 |
| iGMDRD251 | ML162 | 1 |
| iGMDRD158 | NSC141540 | 2 |
| iGMDRD137 | Indisulam | 3 |
| iGMDRD103 | SN-38 | 6 |
| iGMDRD434 | BMS-536924 | 4 |
| iGMDRD105 | Triptolide | 3 |
| iGMDRD289 | Parthenolide | 3 |
| iGMDRD6 | AM-580 | 2 |
| iGMDRD49 | Mitomycin | 3 |
| iGMDRD945 | ML214 | 3 |
| iGMDRD248 | BRD4354 | 4 |
| iGMDRD330 | BRD4132 | 5 |
| iGMDRD84 | Lovastatin acid | 3 |
| iGMDRD701 | NVP-AUY922 | 2 |
| iGMDRD424 | Tamatinib | 5 |
| iGMDRD116 | CD437 | 7 |
| iGMDRD150 | RITA | 5 |
| iGMDRD888 | Compound 44 | 5 |
| iGMDRD506 | Fedratinib | 2 |
| iGMDRD74 | Idarubicin | 2 |
| iGMDRD188 | Piperlongumine | 6 |
| iGMDRD23 | Gossypol | 4 |
| iGMDRD255 | SB225002 | 1 |
| iGMDRD260 | FQI-2 | 2 |
| iGMDRD138 | PX 12 | 5 |
| iGMDRD480 | KU0060648 | 2 |
| iGMDRD870 | BRD63610 | 1 |
| iGMDRD318 | PAC-1 | 3 |
| iGMDRD226 | ML006 | 2 |
| iGMDRD782 | DC-45-A2 | 3 |
| iGMDRD152 | 179324-69-7 | 1 |
| iGMDRD446 | LY 2183240 | 5 |
| iGMDRD634 | SCHEMBL2608041 | 3 |
| iGMDRD280 | CYTOCHALASIN B | 1 |
| iGMDRD297 | Austocystin D | 3 |
| iGMDRD425 | ERASTIN | 3 |
| iGMDRD772 | BRD4770 | 2 |
| iGMDRD210 | AC55649 | 3 |
| iGMDRD151 | CHM-1 | 1 |
| iGMDRD554 | CHEMBL1434137 | 4 |
| iGMDRD433 | Lexibulin | 3 |
| iGMDRD781 | Sirolimus | 3 |
| iGMDRD144 | NSC95397 | 6 |
| iGMDRD546 | BMS-754807 | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in FLNB
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