PLAG1
Summary: Pleomorphic adenoma gene 1 encodes a zinc finger protein with 2 putative nuclear localization signals. PLAG1, which is developmentally regulated, has been shown to be consistently rearranged in pleomorphic adenomas of the salivary glands. PLAG1 is activated by the reciprocal chromosomal translocations involving 8q12 in a subset of salivary gland pleomorphic adenomas. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| PLAG1 zinc finger | MIM:603026 | Ensembl:ENSG00000181690 | HGNC:HGNC:9045 | PA33378 | 8q12.1 |
GO terms in PLAG1
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IDA | GO:0000978 | RNA polymerase II proximal promoter sequence-specific DNA binding |
| MF | ISA | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | NAS | GO:0000981 | RNA polymerase II transcription factor activity, sequence-specific DNA binding |
| MF | IDA | GO:0001077 | transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding |
| MF | IBA | GO:0003677 | DNA binding |
| MF | IBA | GO:0003700 | DNA-binding transcription factor activity |
| MF | TAS | GO:0003700 | DNA-binding transcription factor activity |
| MF | IEA | GO:0046872 | metal ion binding |
| BP | IBA | GO:0006355 | regulation of transcription, DNA-templated |
| BP | IEA | GO:0006366 | transcription by RNA polymerase II |
| BP | IEA | GO:0010629 | negative regulation of gene expression |
| BP | IEA | GO:0022612 | gland morphogenesis |
| BP | IEA | GO:0035264 | multicellular organism growth |
| BP | IDA | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IEA | GO:0060252 | positive regulation of glial cell proliferation |
| BP | IEA | GO:0060736 | prostate gland growth |
| CC | IBA | GO:0005634 | nucleus |
| CC | IDA | GO:0016607 | nuclear speck |
Gene expression in normal tissue: PLAG1
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PLAG1
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP2004 | miR-targeted genes in lymphocytes - TarBase |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD123 | Isoevodiamine | 3 |
| iGMDRD177 | Teniposide | 1 |
| iGMDRD375 | GW-405833 | 3 |
| iGMDRD511 | CHEMBL399379 | 3 |
| iGMDRD154 | NSC23766 | 3 |
| iGMDRD351 | GW843682X | 3 |
| iGMDRD314 | Tanespimycin | 2 |
| iGMDRD427 | ABT737 | 3 |
| iGMDRD523 | Cyanoquinoline, 11 | 3 |
| iGMDRD701 | NVP-AUY922 | 6 |
| iGMDRD579 | PF750 | 1 |
| iGMDRD1008 | SR-II-138A | 3 |
| iGMDRD451 | Serdemetan | 3 |
| iGMDRD188 | Piperlongumine | 2 |
| iGMDRD74 | Idarubicin | 2 |
| iGMDRD398 | Sepantronium | 3 |
| iGMDRD562 | Navitoclax | 3 |
| iGMDRD171 | Pemetrexed | 1 |
| iGMDRD481 | Dactolisib | 3 |
| iGMDRD187 | BRD9876 | 1 |
| iGMDRD77 | Itraconazole | 3 |
| iGMDRD103 | SN-38 | 3 |
| iGMDRD158 | NSC141540 | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PLAG1
CLASSFICATION
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