PLAG1

Summary: Pleomorphic adenoma gene 1 encodes a zinc finger protein with 2 putative nuclear localization signals. PLAG1, which is developmentally regulated, has been shown to be consistently rearranged in pleomorphic adenomas of the salivary glands. PLAG1 is activated by the reciprocal chromosomal translocations involving 8q12 in a subset of salivary gland pleomorphic adenomas. Three transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].

Loading, please wait...
Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
NamePLAG1 zinc finger
OMIM IDMIM:603026
Ensembl IDEnsembl:ENSG00000181690
HGNC IDHGNC:HGNC:9045
PHARMGKB IDPA33378
Map Location8q12.1

GO terms in PLAG1


Loading, please wait...
Term Type
Evidence Type
GO Term ID
GO Des.
MF IDA GO:0000978 RNA polymerase II proximal promoter sequence-specific DNA binding
MF ISA GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
MF NAS GO:0000981 RNA polymerase II transcription factor activity, sequence-specific DNA binding
MF IDA GO:0001077 transcriptional activator activity, RNA polymerase II proximal promoter sequence-specific DNA binding
MF IBA GO:0003677 DNA binding
MF IBA GO:0003700 DNA-binding transcription factor activity
Showing 1 to 6 of 18 rows rows per page

Gene expression in normal tissue: PLAG1

16 tissues mixtureadiposeadrenalbrainbreastcolonheartkidneyliverlunglymph nodeovaryprostateskeletal muscletestesthyroidwhite blood cells

Gene-model tissue-cancer distribution: Bubble Plot

LUNtissue: LUN cancer: LUNG model num: 0LUNGtissue: LUNG cancer: undefined model num: 12BOWEtissue: BOWE cancer: BOWEL model num: 0BOWELtissue: BOWEL cancer: undefined model num: 19undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 30

Gene-drug pathway distribution

undefined13Apoptosis regulation2Protein stability and degradation2DNA replication2PI3K/MTOR signaling1p53 pathway1Cell cycle1One carbon pool by folate1

Pathways in PLAG1


Loading, please wait...
Database
Pathway ID
Pathway Des.
wikipathways WP2004 miR-targeted genes in lymphocytes - TarBase
Showing 1 to 1 of 1 rows

Gene-Drug: Aster Plot


Loading, please wait...
Drug ID
Drug Name
Model Num.
iGMDRD123 Isoevodiamine 3
iGMDRD177 Teniposide 1
iGMDRD375 GW-405833 3
iGMDRD511 CHEMBL399379 3
Showing 1 to 4 of 23 rows rows per page

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in PLAG1

Loading, please wait...
Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

​​​​

SITE
DATATYPES
CLASSFICATION
Map

Copyright © 2018 Modellab | All Rights Reserved

Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.