GRK7
Summary: This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. It is specifically expressed in the retina and the encoded protein has been shown to phosphorylate cone opsins and initiate their deactivation. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| G protein-coupled receptor kinase 7 | MIM:606987 | Ensembl:ENSG00000114124 | HGNC:HGNC:17031 | PA38433 | 3q23 |
GO terms in GRK7
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IEA | GO:0004703 | G-protein coupled receptor kinase activity |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IDA | GO:0050254 | rhodopsin kinase activity |
| MF | TAS | GO:0050254 | rhodopsin kinase activity |
| CC | TAS | GO:0097381 | photoreceptor disc membrane |
| BP | IEA | GO:0007165 | signal transduction |
| BP | IEA | GO:0007601 | visual perception |
| BP | TAS | GO:0022400 | regulation of rhodopsin mediated signaling pathway |
| BP | IMP | GO:0046777 | protein autophosphorylation |
Gene expression in normal tissue: GRK7
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in GRK7
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| pid | cone_pathway | Visual signal transduction: Cones |
| kegg | hsa04062 | Chemokine signaling pathway - Homo sapiens (human) |
| kegg | hsa04144 | Endocytosis - Homo sapiens (human) |
| kegg | hsa04744 | Phototransduction - Homo sapiens (human) |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-2187338 | Visual phototransduction |
| reactome | R-HSA-2514856 | The phototransduction cascade |
| reactome | R-HSA-2514859 | Inactivation, recovery and regulation of the phototransduction cascade |
| reactome | R-HSA-372790 | Signaling by GPCR |
| reactome | R-HSA-388396 | GPCR downstream signalling |
| reactome | R-HSA-418594 | G alpha (i) signalling events |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD85 | Ursolic acid | 4 |
| iGMDRD341 | Triacsin c | 2 |
| iGMDRD945 | ML214 | 1 |
| iGMDRD177 | Teniposide | 2 |
| iGMDRD123 | Isoevodiamine | 2 |
| iGMDRD512 | nutlin 3 | 4 |
| iGMDRD79 | Gemcitabine | 4 |
| iGMDRD424 | Tamatinib | 1 |
| iGMDRD532 | Olaparib | 3 |
| iGMDRD150 | RITA | 3 |
| iGMDRD116 | CD437 | 2 |
| iGMDRD414 | MST-312 | 3 |
| iGMDRD286 | Nsc 632839 | 3 |
| iGMDRD246 | NPC26 | 2 |
| iGMDRD505 | Pevonedistat | 5 |
| iGMDRD137 | Indisulam | 3 |
| iGMDRD103 | SN-38 | 3 |
| iGMDRD77 | Itraconazole | 2 |
| iGMDRD61 | Kinetin riboside | 7 |
| iGMDRD193 | Fqi1 | 3 |
| iGMDRD639 | YK 4-279 | 3 |
| iGMDRD446 | LY 2183240 | 9 |
| iGMDRD772 | BRD4770 | 3 |
| iGMDRD889 | Compound 7d-cis | 2 |
| iGMDRD151 | CHM-1 | 2 |
| iGMDRD144 | NSC95397 | 2 |
| iGMDRD562 | Navitoclax | 3 |
| iGMDRD888 | Compound 44 | 2 |
| iGMDRD730 | Kahalalide F | 3 |
| iGMDRD74 | Idarubicin | 3 |
| iGMDRD23 | Gossypol | 2 |
| iGMDRD64 | Parbendazole | 3 |
| iGMDRD255 | SB225002 | 2 |
| iGMDRD318 | PAC-1 | 1 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in GRK7
CLASSFICATION
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