GRK7
Summary: This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. It is specifically expressed in the retina and the encoded protein has been shown to phosphorylate cone opsins and initiate their deactivation. [provided by RefSeq, Jul 2008].
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Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:606987 Ensembl IDEnsembl:ENSG00000114124 HGNC IDHGNC:HGNC:17031 PHARMGKB IDPA38433 Map Location3q23 | |||||
GO terms in GRK7
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Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IEA | GO:0004703 | G-protein coupled receptor kinase activity |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IDA | GO:0050254 | rhodopsin kinase activity |
| MF | TAS | GO:0050254 | rhodopsin kinase activity |
| CC | TAS | GO:0097381 | photoreceptor disc membrane |
| BP | IEA | GO:0007165 | signal transduction |
Gene expression in normal tissue: GRK7
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in GRK7
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Database | Pathway ID | Pathway Des. |
|---|---|---|
| pid | cone_pathway | Visual signal transduction: Cones |
| kegg | hsa04062 | Chemokine signaling pathway - Homo sapiens (human) |
| kegg | hsa04144 | Endocytosis - Homo sapiens (human) |
| kegg | hsa04744 | Phototransduction - Homo sapiens (human) |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-2187338 | Visual phototransduction |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in GRK7
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Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
CLASSFICATION
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