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BNIP3

Summary: This gene is encodes a mitochondrial protein that contains a BH3 domain and acts as a pro-apoptotic factor. The encoded protein interacts with anti-apoptotic proteins, including the E1B 19 kDa protein and Bcl2. This gene is silenced in tumors by DNA methylation. [provided by RefSeq, Dec 2014].

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Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
NameBCL2 interacting protein 3 OMIM IDMIM:603293 Ensembl IDEnsembl:ENSG00000176171 HGNC IDHGNC:HGNC:1084 PHARMGKB IDPA25394 Map Location10q26.3

GO terms in BNIP3

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Term Type	Evidence Type	GO Term ID	GO Des.
BP	NAS	GO:0000422	autophagy of mitochondrion
BP	ISS	GO:0001666	response to hypoxia
BP	IPI	GO:0006915	apoptotic process
BP	ISS	GO:0008219	cell death
BP	IDA	GO:0008626	granzyme-mediated apoptotic signaling pathway
BP	TAS	GO:0010508	positive regulation of autophagy

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Gene expression in normal tissue: BNIP3

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in BNIP3

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Database	Pathway ID	Pathway Des.
pharmgkb	PA165374494	Busulfan Pathway, Pharmacodynamics
pid	hif1_tfpathway	HIF-1-alpha transcription factor network
pid	mtor_4pathway	mTOR signaling pathway
kegg	hsa04068	FoxO signaling pathway - Homo sapiens (human)
kegg	hsa04137	Mitophagy - animal - Homo sapiens (human)
kegg	hsa04140	Autophagy - animal - Homo sapiens (human)

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Gene-Drug: Aster Plot

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Drug ID	Drug Name	Model Num.
iGMDRD405	PIK-75	3
iGMDRD512	nutlin 3	3
iGMDRD126	Tipifarnib	6
iGMDRD154	NSC23766	6

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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in BNIP3

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	Model	Level	Reference ID	Tissue	Cancer	Drug	Clinical Response	Source
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