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BNIP3

Summary: This gene is encodes a mitochondrial protein that contains a BH3 domain and acts as a pro-apoptotic factor. The encoded protein interacts with anti-apoptotic proteins, including the E1B 19 kDa protein and Bcl2. This gene is silenced in tumors by DNA methylation. [provided by RefSeq, Dec 2014].

Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
BCL2 interacting protein 3	MIM:603293	Ensembl:ENSG00000176171	HGNC:HGNC:1084	PA25394	10q26.3

GO terms in BNIP3

Term Type	Evidence Type	GO Term ID	GO Des.
BP	NAS	GO:0000422	autophagy of mitochondrion
BP	ISS	GO:0001666	response to hypoxia
BP	IPI	GO:0006915	apoptotic process
BP	ISS	GO:0008219	cell death
BP	IDA	GO:0008626	granzyme-mediated apoptotic signaling pathway
BP	TAS	GO:0010508	positive regulation of autophagy
BP	IDA	GO:0010637	negative regulation of mitochondrial fusion
BP	IEA	GO:0010659	cardiac muscle cell apoptotic process
BP	IEA	GO:0010666	positive regulation of cardiac muscle cell apoptotic process
BP	IEA	GO:0010917	negative regulation of mitochondrial membrane potential
BP	IEA	GO:0010940	positive regulation of necrotic cell death
BP	IEA	GO:0016032	viral process
BP	IGI	GO:0016239	positive regulation of macroautophagy
BP	IEA	GO:0021987	cerebral cortex development
BP	IMP	GO:0035694	mitochondrial protein catabolic process
BP	IDA	GO:0043065	positive regulation of apoptotic process
BP	TAS	GO:0043066	negative regulation of apoptotic process
BP	IBA	GO:0043067	regulation of programmed cell death
BP	IBA	GO:0043068	positive regulation of programmed cell death
BP	IDA	GO:0043068	positive regulation of programmed cell death
BP	IDA	GO:0043243	positive regulation of protein complex disassembly
BP	IDA	GO:0043653	mitochondrial fragmentation involved in apoptotic process
BP	IDA	GO:0045837	negative regulation of membrane potential
BP	IDA	GO:0046902	regulation of mitochondrial membrane permeability
BP	IEA	GO:0048102	autophagic cell death
BP	IEA	GO:0048709	oligodendrocyte differentiation
BP	IEA	GO:0050873	brown fat cell differentiation
BP	ISS	GO:0051402	neuron apoptotic process
BP	IEA	GO:0051561	positive regulation of mitochondrial calcium ion concentration
BP	IDA	GO:0051607	defense response to virus
BP	IEA	GO:0055093	response to hyperoxia
BP	IGI	GO:0060548	negative regulation of cell death
BP	IEA	GO:0070301	cellular response to hydrogen peroxide
BP	IEP	GO:0071260	cellular response to mechanical stimulus
BP	IMP	GO:0071279	cellular response to cobalt ion
BP	IGI	GO:0071456	cellular response to hypoxia
BP	IMP	GO:0071456	cellular response to hypoxia
BP	IDA	GO:0072593	reactive oxygen species metabolic process
BP	IDA	GO:0090141	positive regulation of mitochondrial fission
BP	IDA	GO:0090200	positive regulation of release of cytochrome c from mitochondria
BP	IBA	GO:0097345	mitochondrial outer membrane permeabilization
BP	IDA	GO:0097345	mitochondrial outer membrane permeabilization
BP	IEA	GO:1901998	toxin transport
BP	IEA	GO:1902109	negative regulation of mitochondrial membrane permeability involved in apoptotic process
BP	IEA	GO:1903599	positive regulation of autophagy of mitochondrion
BP	IEA	GO:1903715	regulation of aerobic respiration
BP	IMP	GO:1990144	intrinsic apoptotic signaling pathway in response to hypoxia
BP	IEA	GO:2000378	negative regulation of reactive oxygen species metabolic process
CC	ISS	GO:0005634	nucleus
CC	IBA	GO:0005635	nuclear envelope
CC	IDA	GO:0005635	nuclear envelope
CC	ISS	GO:0005654	nucleoplasm
CC	ISS	GO:0005737	cytoplasm
CC	IDA	GO:0005739	mitochondrion
CC	TAS	GO:0005739	mitochondrion
CC	IBA	GO:0005741	mitochondrial outer membrane
CC	IDA	GO:0005741	mitochondrial outer membrane
CC	IBA	GO:0005783	endoplasmic reticulum
CC	NAS	GO:0005783	endoplasmic reticulum
CC	IEA	GO:0014069	postsynaptic density
CC	ISS	GO:0030425	dendrite
CC	IDA	GO:0031307	integral component of mitochondrial outer membrane
CC	IDA	GO:0031966	mitochondrial membrane
CC	IMP	GO:0031966	mitochondrial membrane
MF	IPI	GO:0005515	protein binding
MF	IPI	GO:0042802	identical protein binding
MF	IDA	GO:0042803	protein homodimerization activity
MF	NAS	GO:0042803	protein homodimerization activity
MF	IDA	GO:0046982	protein heterodimerization activity
MF	IPI	GO:0051020	GTPase binding

Gene expression in normal tissue: BNIP3

Select Project:

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in BNIP3

Database	Pathway ID	Pathway Des.
pharmgkb	PA165374494	Busulfan Pathway, Pharmacodynamics
pid	hif1_tfpathway	HIF-1-alpha transcription factor network
pid	mtor_4pathway	mTOR signaling pathway
kegg	hsa04068	FoxO signaling pathway - Homo sapiens (human)
kegg	hsa04137	Mitophagy - animal - Homo sapiens (human)
kegg	hsa04140	Autophagy - animal - Homo sapiens (human)
kegg	hsa05134	Legionellosis - Homo sapiens (human)
wikipathways	WP1772	Apoptosis Modulation and Signaling
wikipathways	WP3614	Photodynamic therapy-induced HIF-1 survival signaling

Gene-Drug: Aster Plot

Drug ID	Drug Name	Model Num.
iGMDRD405	PIK-75	3
iGMDRD512	nutlin 3	3
iGMDRD126	Tipifarnib	6
iGMDRD154	NSC23766	6
iGMDRD375	GW-405833	2
iGMDRD634	SCHEMBL2608041	3
iGMDRD177	Teniposide	1
iGMDRD314	Tanespimycin	5
iGMDRD294	Batimastat	3
iGMDRD187	BRD9876	2
iGMDRD801	2,4-dideoxy-DC-45-A2	3
iGMDRD171	Pemetrexed	1
iGMDRD782	DC-45-A2	3
iGMDRD802	4-methylfasudil	3
iGMDRD158	NSC141540	6
iGMDRD137	Indisulam	1
iGMDRD451	Serdemetan	6
iGMDRD356	PNU-74654	1
iGMDRD300	Tozasertib	4
iGMDRD506	Fedratinib	4
iGMDRD74	Idarubicin	5
iGMDRD872	BRD7137	3

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in BNIP3

SITE

DATATYPES

CLASSFICATION

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