TRRAP


Summary: This gene encodes a large multidomain protein of the phosphoinositide 3-kinase-related kinases (PIKK) family. The encoded protein is a common component of many histone acetyltransferase (HAT) complexes and plays a role in transcription and DNA repair by recruiting HAT complexes to chromatin. Deregulation of this gene may play a role in several types of cancer including glioblastoma multiforme. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
transformation/transcription domain associated proteinMIM:603015Ensembl:ENSG00000196367HGNC:HGNC:12347PA370207q22.1

GO terms in TRRAP


Term TypeEvidence TypeGO Term IDGO Des.
BPIBAGO:0006281DNA repair
BPIEAGO:0006351transcription, DNA-templated
BPIEAGO:0006355regulation of transcription, DNA-templated
BPIEAGO:0016310phosphorylation
BPNASGO:0016573histone acetylation
BPIDAGO:0016578histone deubiquitination
BPTASGO:0016579protein deubiquitination
BPIDAGO:0043967histone H4 acetylation
BPIDAGO:0043968histone H2A acetylation
BPTASGO:1904837beta-catenin-TCF complex assembly
CCNASGO:0000125PCAF complex
CCIDAGO:0000812Swr1 complex
CCIBAGO:0005634nucleus
CCIDAGO:0005634nucleus
CCIDAGO:0005654nucleoplasm
CCTASGO:0005654nucleoplasm
CCIDAGO:0005794Golgi apparatus
CCIDAGO:0030914STAGA complex
CCIDAGO:0033276transcription factor TFTC complex
CCIDAGO:0035267NuA4 histone acetyltransferase complex
MFIDAGO:0003712transcription coregulator activity
MFIPIGO:0005515protein binding
MFIBAGO:0016301kinase activity
MFTASGO:0036459thiol-dependent ubiquitinyl hydrolase activity

Gene expression in normal tissue: TRRAP

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in TRRAP


DatabasePathway IDPathway Des.
biocartapitx2pathwaymulti-step regulation of transcription by pitx2
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-195721Signaling by WNT
reactomeR-HSA-195721Signaling by WNT
reactomeR-HSA-201681TCF dependent signaling in response to WNT
reactomeR-HSA-201681TCF dependent signaling in response to WNT
reactomeR-HSA-201722Formation of the beta-catenin:TCF transactivating complex
reactomeR-HSA-201722Formation of the beta-catenin:TCF transactivating complex
reactomeR-HSA-3214847HATs acetylate histones
reactomeR-HSA-3247509Chromatin modifying enzymes
reactomeR-HSA-392499Metabolism of proteins
reactomeR-HSA-4839726Chromatin organization
reactomeR-HSA-5688426Deubiquitination
reactomeR-HSA-5689880Ub-specific processing proteases
reactomeR-HSA-597592Post-translational protein modification
pidbetacatenin_nuc_pathwayRegulation of nuclear beta catenin signaling and target gene transcription
pide2f_pathwayE2F transcription factor network
pidmyc_activpathwayValidated targets of C-MYC transcriptional activation
pidmyc_pathwayC-MYC pathway
pidp53downstreampathwayDirect p53 effectors
kegghsa05166HTLV-I infection - Homo sapiens (human)

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD138PX 124
iGMDRD255SB2250024
iGMDRD441TW 372
iGMDRD100Zebularine3
iGMDRD887Compound 23 citrate1
iGMDRD562Navitoclax4
iGMDRD690PRIMA-1MET2
iGMDRD599Salermide2
iGMDRD1008SR-II-138A2
iGMDRD579PF7502
iGMDRD772BRD47703
iGMDRD144NSC953975
iGMDRD494Neopeltolide1
iGMDRD446LY 21832401
iGMDRD201SKI II2
iGMDRD193Fqi14
iGMDRD297Austocystin D2
iGMDRD634SCHEMBL26080415
iGMDRD6AM-5802
iGMDRD434BMS-5369243
iGMDRD267Oligomycin A5
iGMDRD872BRD71377
iGMDRD505Pevonedistat4
iGMDRD246NPC262
iGMDRD353PD03259011
iGMDRD84Lovastatin acid3
iGMDRD307Manumycin A3
iGMDRD486Tosedostat4
iGMDRD512nutlin 32
iGMDRD148Pifithrin-mu5
iGMDRD116CD4373
iGMDRD57Chloropentafluorobenzene1
iGMDRD901ELCPK4
iGMDRD177Teniposide4
iGMDRD132(-)-gallocatechin-3-O-gallate3
iGMDRD260FQI-24
iGMDRD171Pemetrexed3
iGMDRD8012,4-dideoxy-DC-45-A21
iGMDRD399Selumetinib7
iGMDRD74Idarubicin2
iGMDRD64Parbendazole6
iGMDRD524ISX-95
iGMDRD151CHM-14
iGMDRD433Lexibulin3
iGMDRD889Compound 7d-cis3
iGMDRD420Leucascandrolide A3
iGMDRD427ABT7376
iGMDRD483SCH-5290745
iGMDRD639YK 4-2793
iGMDRD152179324-69-72
iGMDRD466Chaetocin10
iGMDRD103SN-383
iGMDRD121GMX17781
iGMDRD137Indisulam2
iGMDRD158NSC1415406
iGMDRD202Curcumin5
iGMDRD705Nakiterpiosin3
iGMDRD105Triptolide2
iGMDRD289Parthenolide5
iGMDRD367Ro 28-16752
iGMDRD286Nsc 6328394
iGMDRD871BRD63682
iGMDRD329Merck602
iGMDRD263AACOCF33
iGMDRD552AZD-17753
iGMDRD147Prima-13
iGMDRD79Gemcitabine1
iGMDRD405PIK-752
iGMDRD237ABT-7512
iGMDRD123Isoevodiamine6
iGMDRD945ML2145

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in TRRAP

​​​​