TRRAP
Summary: This gene encodes a large multidomain protein of the phosphoinositide 3-kinase-related kinases (PIKK) family. The encoded protein is a common component of many histone acetyltransferase (HAT) complexes and plays a role in transcription and DNA repair by recruiting HAT complexes to chromatin. Deregulation of this gene may play a role in several types of cancer including glioblastoma multiforme. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| transformation/transcription domain associated protein | MIM:603015 | Ensembl:ENSG00000196367 | HGNC:HGNC:12347 | PA37020 | 7q22.1 |
GO terms in TRRAP
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IBA | GO:0006281 | DNA repair |
| BP | IEA | GO:0006351 | transcription, DNA-templated |
| BP | IEA | GO:0006355 | regulation of transcription, DNA-templated |
| BP | IEA | GO:0016310 | phosphorylation |
| BP | NAS | GO:0016573 | histone acetylation |
| BP | IDA | GO:0016578 | histone deubiquitination |
| BP | TAS | GO:0016579 | protein deubiquitination |
| BP | IDA | GO:0043967 | histone H4 acetylation |
| BP | IDA | GO:0043968 | histone H2A acetylation |
| BP | TAS | GO:1904837 | beta-catenin-TCF complex assembly |
| CC | NAS | GO:0000125 | PCAF complex |
| CC | IDA | GO:0000812 | Swr1 complex |
| CC | IBA | GO:0005634 | nucleus |
| CC | IDA | GO:0005634 | nucleus |
| CC | IDA | GO:0005654 | nucleoplasm |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IDA | GO:0005794 | Golgi apparatus |
| CC | IDA | GO:0030914 | STAGA complex |
| CC | IDA | GO:0033276 | transcription factor TFTC complex |
| CC | IDA | GO:0035267 | NuA4 histone acetyltransferase complex |
| MF | IDA | GO:0003712 | transcription coregulator activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IBA | GO:0016301 | kinase activity |
| MF | TAS | GO:0036459 | thiol-dependent ubiquitinyl hydrolase activity |
Gene expression in normal tissue: TRRAP
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in TRRAP
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| biocarta | pitx2pathway | multi-step regulation of transcription by pitx2 |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-195721 | Signaling by WNT |
| reactome | R-HSA-195721 | Signaling by WNT |
| reactome | R-HSA-201681 | TCF dependent signaling in response to WNT |
| reactome | R-HSA-201681 | TCF dependent signaling in response to WNT |
| reactome | R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex |
| reactome | R-HSA-201722 | Formation of the beta-catenin:TCF transactivating complex |
| reactome | R-HSA-3214847 | HATs acetylate histones |
| reactome | R-HSA-3247509 | Chromatin modifying enzymes |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-4839726 | Chromatin organization |
| reactome | R-HSA-5688426 | Deubiquitination |
| reactome | R-HSA-5689880 | Ub-specific processing proteases |
| reactome | R-HSA-597592 | Post-translational protein modification |
| pid | betacatenin_nuc_pathway | Regulation of nuclear beta catenin signaling and target gene transcription |
| pid | e2f_pathway | E2F transcription factor network |
| pid | myc_activpathway | Validated targets of C-MYC transcriptional activation |
| pid | myc_pathway | C-MYC pathway |
| pid | p53downstreampathway | Direct p53 effectors |
| kegg | hsa05166 | HTLV-I infection - Homo sapiens (human) |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD138 | PX 12 | 4 |
| iGMDRD255 | SB225002 | 4 |
| iGMDRD441 | TW 37 | 2 |
| iGMDRD100 | Zebularine | 3 |
| iGMDRD887 | Compound 23 citrate | 1 |
| iGMDRD562 | Navitoclax | 4 |
| iGMDRD690 | PRIMA-1MET | 2 |
| iGMDRD599 | Salermide | 2 |
| iGMDRD1008 | SR-II-138A | 2 |
| iGMDRD579 | PF750 | 2 |
| iGMDRD772 | BRD4770 | 3 |
| iGMDRD144 | NSC95397 | 5 |
| iGMDRD494 | Neopeltolide | 1 |
| iGMDRD446 | LY 2183240 | 1 |
| iGMDRD201 | SKI II | 2 |
| iGMDRD193 | Fqi1 | 4 |
| iGMDRD297 | Austocystin D | 2 |
| iGMDRD634 | SCHEMBL2608041 | 5 |
| iGMDRD6 | AM-580 | 2 |
| iGMDRD434 | BMS-536924 | 3 |
| iGMDRD267 | Oligomycin A | 5 |
| iGMDRD872 | BRD7137 | 7 |
| iGMDRD505 | Pevonedistat | 4 |
| iGMDRD246 | NPC26 | 2 |
| iGMDRD353 | PD0325901 | 1 |
| iGMDRD84 | Lovastatin acid | 3 |
| iGMDRD307 | Manumycin A | 3 |
| iGMDRD486 | Tosedostat | 4 |
| iGMDRD512 | nutlin 3 | 2 |
| iGMDRD148 | Pifithrin-mu | 5 |
| iGMDRD116 | CD437 | 3 |
| iGMDRD57 | Chloropentafluorobenzene | 1 |
| iGMDRD901 | ELCPK | 4 |
| iGMDRD177 | Teniposide | 4 |
| iGMDRD132 | (-)-gallocatechin-3-O-gallate | 3 |
| iGMDRD260 | FQI-2 | 4 |
| iGMDRD171 | Pemetrexed | 3 |
| iGMDRD801 | 2,4-dideoxy-DC-45-A2 | 1 |
| iGMDRD399 | Selumetinib | 7 |
| iGMDRD74 | Idarubicin | 2 |
| iGMDRD64 | Parbendazole | 6 |
| iGMDRD524 | ISX-9 | 5 |
| iGMDRD151 | CHM-1 | 4 |
| iGMDRD433 | Lexibulin | 3 |
| iGMDRD889 | Compound 7d-cis | 3 |
| iGMDRD420 | Leucascandrolide A | 3 |
| iGMDRD427 | ABT737 | 6 |
| iGMDRD483 | SCH-529074 | 5 |
| iGMDRD639 | YK 4-279 | 3 |
| iGMDRD152 | 179324-69-7 | 2 |
| iGMDRD466 | Chaetocin | 10 |
| iGMDRD103 | SN-38 | 3 |
| iGMDRD121 | GMX1778 | 1 |
| iGMDRD137 | Indisulam | 2 |
| iGMDRD158 | NSC141540 | 6 |
| iGMDRD202 | Curcumin | 5 |
| iGMDRD705 | Nakiterpiosin | 3 |
| iGMDRD105 | Triptolide | 2 |
| iGMDRD289 | Parthenolide | 5 |
| iGMDRD367 | Ro 28-1675 | 2 |
| iGMDRD286 | Nsc 632839 | 4 |
| iGMDRD871 | BRD6368 | 2 |
| iGMDRD329 | Merck60 | 2 |
| iGMDRD263 | AACOCF3 | 3 |
| iGMDRD552 | AZD-1775 | 3 |
| iGMDRD147 | Prima-1 | 3 |
| iGMDRD79 | Gemcitabine | 1 |
| iGMDRD405 | PIK-75 | 2 |
| iGMDRD237 | ABT-751 | 2 |
| iGMDRD123 | Isoevodiamine | 6 |
| iGMDRD945 | ML214 | 5 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in TRRAP
CLASSFICATION
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