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TRRAP

Summary: This gene encodes a large multidomain protein of the phosphoinositide 3-kinase-related kinases (PIKK) family. The encoded protein is a common component of many histone acetyltransferase (HAT) complexes and plays a role in transcription and DNA repair by recruiting HAT complexes to chromatin. Deregulation of this gene may play a role in several types of cancer including glioblastoma multiforme. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Sep 2011].

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Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
Nametransformation/transcription domain associated protein OMIM IDMIM:603015 Ensembl IDEnsembl:ENSG00000196367 HGNC IDHGNC:HGNC:12347 PHARMGKB IDPA37020 Map Location7q22.1

Gene Categories:

TRANSCRIPTION FACTOR COMPLEX PROTEASE KINASE PHOSPHATIDYLINOSITOL 3 KINASE DNA REPAIR SERINE THREONINE KINASE DRUGGABLE GENOME HISTONE MODIFICATION

GO terms in TRRAP

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Term Type	Evidence Type	GO Term ID	GO Des.
BP	IBA	GO:0006281	DNA repair
BP	IEA	GO:0006351	transcription, DNA-templated
BP	IEA	GO:0006355	regulation of transcription, DNA-templated
BP	IEA	GO:0016310	phosphorylation
BP	NAS	GO:0016573	histone acetylation
BP	IDA	GO:0016578	histone deubiquitination

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Gene expression in normal tissue: TRRAP

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in TRRAP

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Database	Pathway ID	Pathway Des.
biocarta	pitx2pathway	multi-step regulation of transcription by pitx2
reactome	R-HSA-162582	Signal Transduction
reactome	R-HSA-162582	Signal Transduction
reactome	R-HSA-195721	Signaling by WNT
reactome	R-HSA-195721	Signaling by WNT
reactome	R-HSA-201681	TCF dependent signaling in response to WNT

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Gene-Drug: Aster Plot

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Drug ID	Drug Name	Model Num.
iGMDRD138	PX 12	4
iGMDRD255	SB225002	4
iGMDRD441	TW 37	2
iGMDRD100	Zebularine	3

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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in TRRAP

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	Model	Level	Reference ID	Tissue	Cancer	Drug	Clinical Response	Source
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