CDK3
Summary: This gene encodes a member of the cyclin-dependent protein kinase family. The protein promotes entry into S phase, in part by activating members of the E2F family of transcription factors. The protein also associates with cyclin C and phosphorylates the retinoblastoma 1 protein to promote exit from G0. [provided by RefSeq, Jul 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| cyclin dependent kinase 3 | MIM:123828 | Ensembl:ENSG00000250506 | HGNC:HGNC:1772 | PA26309 | 17q25.1 |
GO terms in CDK3
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IBA | GO:0004693 | cyclin-dependent protein serine/threonine kinase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| CC | IBA | GO:0005634 | nucleus |
| BP | TAS | GO:0000082 | G1/S transition of mitotic cell cycle |
| BP | IBA | GO:0006468 | protein phosphorylation |
| BP | IDA | GO:0006974 | cellular response to DNA damage stimulus |
| BP | TAS | GO:0008283 | cell proliferation |
| BP | TAS | GO:0045023 | G0 to G1 transition |
| BP | IEA | GO:0051301 | cell division |
Gene expression in normal tissue: CDK3
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CDK3
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| biocarta | efppathway | estrogen responsive protein efp controls cell cycle and breast tumors growth |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD121 | GMX1778 | 3 |
| iGMDRD550 | CGP-082996 | 1 |
| iGMDRD513 | BML-259 | 1 |
| iGMDRD434 | BMS-536924 | 1 |
| iGMDRD289 | Parthenolide | 3 |
| iGMDRD187 | BRD9876 | 6 |
| iGMDRD74 | Idarubicin | 3 |
| iGMDRD329 | Merck60 | 3 |
| iGMDRD64 | Parbendazole | 3 |
| iGMDRD886 | Compound 1541A | 3 |
| iGMDRD322 | FK 866 | 3 |
| iGMDRD1008 | SR-II-138A | 3 |
| iGMDRD85 | Ursolic acid | 1 |
| iGMDRD193 | Fqi1 | 3 |
| iGMDRD280 | CYTOCHALASIN B | 3 |
| iGMDRD123 | Isoevodiamine | 4 |
| iGMDRD634 | SCHEMBL2608041 | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CDK3
CLASSFICATION
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