PLK3
Summary: The protein encoded by this gene is a member of the highly conserved polo-like kinase family of serine/threonine kinases. Members of this family are characterized by an amino-terminal kinase domain and a carboxy-terminal bipartite polo box domain that functions as a substrate-binding motif and a cellular localization signal. Polo-like kinases are important regulators of cell cycle progression. This gene has also been implicated in stress responses and double-strand break repair. In human cell lines, this protein is reported to associate with centrosomes in a microtubule-dependent manner, and during mitosis, the protein becomes localized to the mitotic apparatus. Expression of a kinase-defective mutant results in abnormal cell morphology caused by changes in microtubule dynamics and mitotic arrest followed by apoptosis. [provided by RefSeq, Sep 2015].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| polo like kinase 3 | MIM:602913 | Ensembl:ENSG00000173846 | HGNC:HGNC:2154 | PA26664 | 1p34.1 |
GO terms in PLK3
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IDA | GO:0002039 | p53 binding |
| MF | IDA | GO:0004674 | protein serine/threonine kinase activity |
| MF | TAS | GO:0004674 | protein serine/threonine kinase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| BP | IMP | GO:0000082 | G1/S transition of mitotic cell cycle |
| BP | TAS | GO:0000086 | G2/M transition of mitotic cell cycle |
| BP | IDA | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| BP | IDA | GO:0000302 | response to reactive oxygen species |
| BP | IEA | GO:0006468 | protein phosphorylation |
| BP | TAS | GO:0006915 | apoptotic process |
| BP | IDA | GO:0006970 | response to osmotic stress |
| BP | IDA | GO:0006974 | cellular response to DNA damage stimulus |
| BP | IMP | GO:0006974 | cellular response to DNA damage stimulus |
| BP | TAS | GO:0006977 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest |
| BP | TAS | GO:0007093 | mitotic cell cycle checkpoint |
| BP | TAS | GO:0007113 | endomitotic cell cycle |
| BP | IDA | GO:0009314 | response to radiation |
| BP | IMP | GO:0031122 | cytoplasmic microtubule organization |
| BP | IMP | GO:0032465 | regulation of cytokinesis |
| BP | TAS | GO:0032465 | regulation of cytokinesis |
| BP | IDA | GO:0043066 | negative regulation of apoptotic process |
| BP | ISS | GO:0043491 | protein kinase B signaling |
| BP | ISS | GO:0044819 | mitotic G1/S transition checkpoint |
| BP | IDA | GO:0051302 | regulation of cell division |
| BP | IDA | GO:0090166 | Golgi disassembly |
| BP | IMP | GO:0090316 | positive regulation of intracellular protein transport |
| BP | TAS | GO:1901796 | regulation of signal transduction by p53 class mediator |
| BP | IDA | GO:1904716 | positive regulation of chaperone-mediated autophagy |
| BP | IDA | GO:2000777 | positive regulation of proteasomal ubiquitin-dependent protein catabolic process involved in cellular response to hypoxia |
| CC | IDA | GO:0005634 | nucleus |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IDA | GO:0005730 | nucleolus |
| CC | IDA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005795 | Golgi stack |
| CC | IDA | GO:0005813 | centrosome |
| CC | IEA | GO:0030425 | dendrite |
| CC | IEA | GO:0043025 | neuronal cell body |
Gene expression in normal tissue: PLK3
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in PLK3
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP1984 | Integrated Breast Cancer Pathway |
| wikipathways | WP3804 | TP53 Regulates Transcription of Cell Cycle Genes |
| kegg | hsa04068 | FoxO signaling pathway - Homo sapiens (human) |
| kegg | hsa04625 | C-type lectin receptor signaling pathway - Homo sapiens (human) |
| kegg | hsa05152 | Tuberculosis - Homo sapiens (human) |
| pid | p53downstreampathway | Direct p53 effectors |
| pid | p73pathway | p73 transcription factor network |
| pid | plk3_pathway | PLK3 signaling events |
| biocarta | plk3pathway | regulation of cell cycle progression by plk3 |
| reactome | R-HSA-212436 | Generic Transcription Pathway |
| reactome | R-HSA-3700989 | Transcriptional Regulation by TP53 |
| reactome | R-HSA-5633007 | Regulation of TP53 Activity |
| reactome | R-HSA-6791312 | TP53 Regulates Transcription of Cell Cycle Genes |
| reactome | R-HSA-6804115 | TP53 regulates transcription of additional cell cycle genes whose exact role in the p53 pathway remain uncertain |
| reactome | R-HSA-6804756 | Regulation of TP53 Activity through Phosphorylation |
| reactome | R-HSA-73857 | RNA Polymerase II Transcription |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD61 | Kinetin riboside | 1 |
| iGMDRD193 | Fqi1 | 2 |
| iGMDRD499 | PDMP | 3 |
| iGMDRD466 | Chaetocin | 2 |
| iGMDRD123 | Isoevodiamine | 2 |
| iGMDRD154 | NSC23766 | 4 |
| iGMDRD883 | CIL55A | 1 |
| iGMDRD579 | PF750 | 2 |
| iGMDRD424 | Tamatinib | 1 |
| iGMDRD670 | ML 210 | 2 |
| iGMDRD79 | Gemcitabine | 2 |
| iGMDRD483 | SCH-529074 | 3 |
| iGMDRD74 | Idarubicin | 4 |
| iGMDRD100 | Zebularine | 5 |
| iGMDRD188 | Piperlongumine | 3 |
| iGMDRD269 | Purmorphamine | 2 |
| iGMDRD506 | Fedratinib | 1 |
| iGMDRD329 | Merck60 | 4 |
| iGMDRD64 | Parbendazole | 2 |
| iGMDRD524 | ISX-9 | 3 |
| iGMDRD356 | PNU-74654 | 2 |
| iGMDRD137 | Indisulam | 2 |
| iGMDRD138 | PX 12 | 2 |
| iGMDRD289 | Parthenolide | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in PLK3
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