CASP3
Summary: The protein encoded by this gene is a cysteine-aspartic acid protease that plays a central role in the execution-phase of cell apoptosis. The encoded protein cleaves and inactivates poly(ADP-ribose) polymerase while it cleaves and activates sterol regulatory element binding proteins as well as caspases 6, 7, and 9. This protein itself is processed by caspases 8, 9, and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. [provided by RefSeq, Aug 2017].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
Namecaspase 3 OMIM IDMIM:600636 Ensembl IDEnsembl:ENSG00000164305 HGNC IDHGNC:HGNC:1504 PHARMGKB IDPA26087 Map Location4q35.1 | |||||
GO terms in CASP3
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IEA | GO:0002020 | protease binding |
| MF | EXP | GO:0004190 | aspartic-type endopeptidase activity |
| MF | IDA | GO:0004197 | cysteine-type endopeptidase activity |
| MF | TAS | GO:0004197 | cysteine-type endopeptidase activity |
| MF | IEA | GO:0004861 | cyclin-dependent protein serine/threonine kinase inhibitor activity |
| MF | IEA | GO:0005123 | death receptor binding |
Gene expression in normal tissue: CASP3
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CASP3
Database | Pathway ID | Pathway Des. |
|---|---|---|
| biocarta | bcellsurvivalpathway | b cell survival pathway |
| biocarta | caspasepathway | caspase cascade in apoptosis |
| biocarta | chemicalpathway | apoptotic signaling in response to dna damage |
| biocarta | d4gdipathway | d4gdi signaling pathway |
| biocarta | deathpathway | induction of apoptosis through dr3 and dr4/5 death receptors |
| biocarta | dnafragmentpathway | apoptotic dna-fragmentation and tissue homeostasis |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CASP3
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
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