CASP3
Summary: The protein encoded by this gene is a cysteine-aspartic acid protease that plays a central role in the execution-phase of cell apoptosis. The encoded protein cleaves and inactivates poly(ADP-ribose) polymerase while it cleaves and activates sterol regulatory element binding proteins as well as caspases 6, 7, and 9. This protein itself is processed by caspases 8, 9, and 10. It is the predominant caspase involved in the cleavage of amyloid-beta 4A precursor protein, which is associated with neuronal death in Alzheimer's disease. [provided by RefSeq, Aug 2017].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| caspase 3 | MIM:600636 | Ensembl:ENSG00000164305 | HGNC:HGNC:1504 | PA26087 | 4q35.1 |
GO terms in CASP3
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| MF | IEA | GO:0002020 | protease binding |
| MF | EXP | GO:0004190 | aspartic-type endopeptidase activity |
| MF | IDA | GO:0004197 | cysteine-type endopeptidase activity |
| MF | TAS | GO:0004197 | cysteine-type endopeptidase activity |
| MF | IEA | GO:0004861 | cyclin-dependent protein serine/threonine kinase inhibitor activity |
| MF | IEA | GO:0005123 | death receptor binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IDA | GO:0008233 | peptidase activity |
| MF | TAS | GO:0008656 | cysteine-type endopeptidase activator activity involved in apoptotic process |
| MF | IEA | GO:0016005 | phospholipase A2 activator activity |
| MF | IEA | GO:0044877 | protein-containing complex binding |
| MF | IBA | GO:0097153 | cysteine-type endopeptidase activity involved in apoptotic process |
| MF | IDA | GO:0097153 | cysteine-type endopeptidase activity involved in apoptotic process |
| MF | IMP | GO:0097153 | cysteine-type endopeptidase activity involved in apoptotic process |
| MF | IMP | GO:0097200 | cysteine-type endopeptidase activity involved in execution phase of apoptosis |
| BP | IEA | GO:0001666 | response to hypoxia |
| BP | IEA | GO:0001782 | B cell homeostasis |
| BP | TAS | GO:0006309 | apoptotic DNA fragmentation |
| BP | IDA | GO:0006508 | proteolysis |
| BP | IBA | GO:0006915 | apoptotic process |
| BP | IMP | GO:0006915 | apoptotic process |
| BP | IEA | GO:0006919 | activation of cysteine-type endopeptidase activity involved in apoptotic process |
| BP | IEA | GO:0006974 | cellular response to DNA damage stimulus |
| BP | IEA | GO:0007507 | heart development |
| BP | IEA | GO:0007605 | sensory perception of sound |
| BP | IEA | GO:0007611 | learning or memory |
| BP | IEA | GO:0008627 | intrinsic apoptotic signaling pathway in response to osmotic stress |
| BP | IEA | GO:0009411 | response to UV |
| BP | IEA | GO:0009749 | response to glucose |
| BP | IEA | GO:0010165 | response to X-ray |
| BP | TAS | GO:0016241 | regulation of macroautophagy |
| BP | IEA | GO:0016485 | protein processing |
| BP | TAS | GO:0019221 | cytokine-mediated signaling pathway |
| BP | IEA | GO:0021766 | hippocampus development |
| BP | IBA | GO:0030182 | neuron differentiation |
| BP | IBA | GO:0030216 | keratinocyte differentiation |
| BP | IBA | GO:0030218 | erythrocyte differentiation |
| BP | IDA | GO:0030218 | erythrocyte differentiation |
| BP | TAS | GO:0030218 | erythrocyte differentiation |
| BP | TAS | GO:0030220 | platelet formation |
| BP | IEA | GO:0030889 | negative regulation of B cell proliferation |
| BP | IEA | GO:0032025 | response to cobalt ion |
| BP | IEA | GO:0032355 | response to estradiol |
| BP | IEA | GO:0032496 | response to lipopolysaccharide |
| BP | IEA | GO:0034349 | glial cell apoptotic process |
| BP | TAS | GO:0034612 | response to tumor necrosis factor |
| BP | IEA | GO:0035094 | response to nicotine |
| BP | TAS | GO:0035329 | hippo signaling |
| BP | IEA | GO:0042060 | wound healing |
| BP | IEA | GO:0042542 | response to hydrogen peroxide |
| BP | IEA | GO:0043029 | T cell homeostasis |
| BP | IGI | GO:0043066 | negative regulation of apoptotic process |
| BP | IEA | GO:0043200 | response to amino acid |
| BP | IEA | GO:0043525 | positive regulation of neuron apoptotic process |
| BP | IEA | GO:0045165 | cell fate commitment |
| BP | IEA | GO:0045736 | negative regulation of cyclin-dependent protein serine/threonine kinase activity |
| BP | IEA | GO:0046007 | negative regulation of activated T cell proliferation |
| BP | IDA | GO:0048011 | neurotrophin TRK receptor signaling pathway |
| BP | IEA | GO:0051384 | response to glucocorticoid |
| BP | IEA | GO:0051402 | neuron apoptotic process |
| BP | IMP | GO:0072734 | cellular response to staurosporine |
| BP | TAS | GO:0097190 | apoptotic signaling pathway |
| BP | TAS | GO:0097192 | extrinsic apoptotic signaling pathway in absence of ligand |
| BP | IDA | GO:0097194 | execution phase of apoptosis |
| BP | IMP | GO:0097194 | execution phase of apoptosis |
| BP | TAS | GO:0097194 | execution phase of apoptosis |
| CC | IDA | GO:0005634 | nucleus |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IBA | GO:0005737 | cytoplasm |
| CC | IDA | GO:0005829 | cytosol |
| CC | TAS | GO:0005829 | cytosol |
| CC | IEA | GO:0031264 | death-inducing signaling complex |
| CC | IEA | GO:0045121 | membrane raft |
Gene expression in normal tissue: CASP3
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CASP3
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| biocarta | bcellsurvivalpathway | b cell survival pathway |
| biocarta | caspasepathway | caspase cascade in apoptosis |
| biocarta | chemicalpathway | apoptotic signaling in response to dna damage |
| biocarta | d4gdipathway | d4gdi signaling pathway |
| biocarta | deathpathway | induction of apoptosis through dr3 and dr4/5 death receptors |
| biocarta | dnafragmentpathway | apoptotic dna-fragmentation and tissue homeostasis |
| biocarta | faspathway | fas signaling pathway (cd95) |
| biocarta | hivnefpathway | hiv-1 nef: negative effector of fas and tnf |
| biocarta | hsp27pathway | stress induction of hsp regulation |
| biocarta | irespathway | internal ribosome entry pathway |
| biocarta | plk3pathway | regulation of cell cycle progression by plk3 |
| biocarta | setpathway | granzyme a mediated apoptosis pathway |
| biocarta | tffpathway | trefoil factors initiate mucosal healing |
| biocarta | tnfr1pathway | tnfr1 signaling pathway |
| biocarta | tsp1pathway | tsp-1 induced apoptosis in microvascular endothelial cell |
| biocarta | wnvpathway | west nile virus |
| reactome | R-HSA-109581 | Apoptosis |
| reactome | R-HSA-109581 | Apoptosis |
| reactome | R-HSA-109606 | Intrinsic Pathway for Apoptosis |
| reactome | R-HSA-109606 | Intrinsic Pathway for Apoptosis |
| reactome | R-HSA-111459 | Activation of caspases through apoptosome-mediated cleavage |
| reactome | R-HSA-111461 | Cytochrome c-mediated apoptotic response |
| reactome | R-HSA-111463 | SMAC binds to IAPs |
| reactome | R-HSA-111464 | SMAC-mediated dissociation of IAP:caspase complexes |
| reactome | R-HSA-111465 | Apoptotic cleavage of cellular proteins |
| reactome | R-HSA-111469 | SMAC-mediated apoptotic response |
| reactome | R-HSA-111471 | Apoptotic factor-mediated response |
| reactome | R-HSA-111471 | Apoptotic factor-mediated response |
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-140342 | Apoptosis induced DNA fragmentation |
| reactome | R-HSA-1474228 | Degradation of the extracellular matrix |
| reactome | R-HSA-1474244 | Extracellular matrix organization |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-193704 | p75 NTR receptor-mediated signalling |
| reactome | R-HSA-2028269 | Signaling by Hippo |
| reactome | R-HSA-204998 | Cell death signalling via NRAGE, NRIF and NADE |
| reactome | R-HSA-205025 | NADE modulates death signalling |
| reactome | R-HSA-211227 | Activation of DNA fragmentation factor |
| reactome | R-HSA-211736 | Stimulation of the cell death response by PAK-2p34 |
| reactome | R-HSA-264870 | Caspase-mediated cleavage of cytoskeletal proteins |
| reactome | R-HSA-351906 | Apoptotic cleavage of cell adhesion proteins |
| reactome | R-HSA-418889 | via Dependence Receptors in the absence of ligand |
| reactome | R-HSA-418889 | via Dependence Receptors in the absence of ligand |
| reactome | R-HSA-449147 | Signaling by Interleukins |
| reactome | R-HSA-449836 | Other interleukin signaling |
| reactome | R-HSA-5357769 | Caspase activation via extrinsic apoptotic signalling pathway |
| reactome | R-HSA-5357769 | Caspase activation via extrinsic apoptotic signalling pathway |
| reactome | R-HSA-5357801 | Programmed Cell Death |
| reactome | R-HSA-5357801 | Programmed Cell Death |
| reactome | R-HSA-73887 | Death Receptor Signalling |
| reactome | R-HSA-75153 | Apoptotic execution phase |
| reactome | R-HSA-75153 | Apoptotic execution phase |
| wikipathways | WP1530 | miRNA Regulation of DNA Damage Response |
| wikipathways | WP1772 | Apoptosis Modulation and Signaling |
| wikipathways | WP1984 | Integrated Breast Cancer Pathway |
| wikipathways | WP2037 | Prolactin Signaling Pathway |
| wikipathways | WP2059 | Alzheimers Disease |
| wikipathways | WP231 | TNF alpha Signaling Pathway |
| wikipathways | WP2324 | AGE-RAGE pathway |
| wikipathways | WP2328 | Allograft Rejection |
| wikipathways | WP2355 | Corticotropin-releasing hormone signaling pathway |
| wikipathways | WP2371 | Parkinsons Disease Pathway |
| wikipathways | WP2374 | Oncostatin M Signaling Pathway |
| wikipathways | WP2380 | Brain-Derived Neurotrophic Factor (BDNF) signaling pathway |
| wikipathways | WP2431 | Spinal Cord Injury |
| wikipathways | WP2447 | Amyotrophic lateral sclerosis (ALS) |
| wikipathways | WP2507 | Nanomaterial induced apoptosis |
| wikipathways | WP2512 | Integrated Lung Cancer Pathway |
| wikipathways | WP254 | Apoptosis |
| wikipathways | WP314 | Fas Ligand (FasL) pathway and Stress induction of Heat Shock Proteins (HSP) regulation |
| wikipathways | WP3286 | Copper homeostasis |
| wikipathways | WP3639 | Apoptotic Signaling Pathway |
| wikipathways | WP3646 | Hepatitis C and Hepatocellular Carcinoma |
| wikipathways | WP382 | MAPK Signaling Pathway |
| wikipathways | WP384 | Apoptosis Modulation by HSP70 |
| wikipathways | WP3853 | ERK Pathway in Huntington,s Disease |
| wikipathways | WP3941 | Oxidative Damage |
| wikipathways | WP3982 | miRNA regulation of p53 pathway in prostate cancer |
| wikipathways | WP3995 | Prion disease pathway |
| wikipathways | WP4216 | Chromosomal and microsatellite instability in colorectal cancer |
| wikipathways | WP706 | Sudden Infant Death Syndrome (SIDS) Susceptibility Pathways |
| wikipathways | WP707 | DNA Damage Response |
| pid | ajdiss_2pathway | Posttranslational regulation of adherens junction stability and dissassembly |
| pid | caspase_pathway | Caspase Cascade in Apoptosis |
| pid | faspathway | FAS (CD95) signaling pathway |
| pid | hivnefpathway | HIV-1 Nef: Negative effector of Fas and TNF-alpha |
| pid | lysophospholipid_pathway | LPA receptor mediated events |
| pid | nfat_3pathway | Role of Calcineurin-dependent NFAT signaling in lymphocytes |
| pid | nfat_tfpathway | Calcineurin-regulated NFAT-dependent transcription in lymphocytes |
| pid | p75ntrpathway | p75(NTR)-mediated signaling |
| pid | syndecan_2_pathway | Syndecan-2-mediated signaling events |
| netpath | Pathway_AndrogenReceptor | AndrogenReceptor |
| netpath | Pathway_TNFalpha | TNFalpha |
| pharmgkb | PA152241951 | Celecoxib Pathway, Pharmacodynamics |
| kegg | hsa04010 | MAPK signaling pathway - Homo sapiens (human) |
| kegg | hsa04115 | p53 signaling pathway - Homo sapiens (human) |
| kegg | hsa04210 | Apoptosis - Homo sapiens (human) |
| kegg | hsa04215 | Apoptosis - multiple species - Homo sapiens (human) |
| kegg | hsa04650 | Natural killer cell mediated cytotoxicity - Homo sapiens (human) |
| kegg | hsa04657 | IL-17 signaling pathway - Homo sapiens (human) |
| kegg | hsa04668 | TNF signaling pathway - Homo sapiens (human) |
| kegg | hsa04726 | Serotonergic synapse - Homo sapiens (human) |
| kegg | hsa04932 | Non-alcoholic fatty liver disease (NAFLD) - Homo sapiens (human) |
| kegg | hsa04933 | AGE-RAGE signaling pathway in diabetic complications - Homo sapiens (human) |
| kegg | hsa05010 | Alzheimer,s disease - Homo sapiens (human) |
| kegg | hsa05012 | Parkinson,s disease - Homo sapiens (human) |
| kegg | hsa05014 | Amyotrophic lateral sclerosis (ALS) - Homo sapiens (human) |
| kegg | hsa05016 | Huntington,s disease - Homo sapiens (human) |
| kegg | hsa05120 | Epithelial cell signaling in Helicobacter pylori infection - Homo sapiens (human) |
| kegg | hsa05133 | Pertussis - Homo sapiens (human) |
| kegg | hsa05134 | Legionellosis - Homo sapiens (human) |
| kegg | hsa05145 | Toxoplasmosis - Homo sapiens (human) |
| kegg | hsa05146 | Amoebiasis - Homo sapiens (human) |
| kegg | hsa05152 | Tuberculosis - Homo sapiens (human) |
| kegg | hsa05161 | Hepatitis B - Homo sapiens (human) |
| kegg | hsa05165 | Human papillomavirus infection - Homo sapiens (human) |
| kegg | hsa05167 | Kaposi,s sarcoma-associated herpesvirus infection - Homo sapiens (human) |
| kegg | hsa05168 | Herpes simplex infection - Homo sapiens (human) |
| kegg | hsa05200 | Pathways in cancer - Homo sapiens (human) |
| kegg | hsa05203 | Viral carcinogenesis - Homo sapiens (human) |
| kegg | hsa05205 | Proteoglycans in cancer - Homo sapiens (human) |
| kegg | hsa05206 | MicroRNAs in cancer - Homo sapiens (human) |
| kegg | hsa05210 | Colorectal cancer - Homo sapiens (human) |
| kegg | hsa05222 | Small cell lung cancer - Homo sapiens (human) |
| kegg | hsa05416 | Viral myocarditis - Homo sapiens (human) |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD446 | LY 2183240 | 2 |
| iGMDRD639 | YK 4-279 | 3 |
| iGMDRD211 | (1S,3R)-RSL3 | 2 |
| iGMDRD280 | CYTOCHALASIN B | 3 |
| iGMDRD466 | Chaetocin | 2 |
| iGMDRD394 | BX-795 | 1 |
| iGMDRD945 | ML214 | 2 |
| iGMDRD512 | nutlin 3 | 3 |
| iGMDRD772 | BRD4770 | 2 |
| iGMDRD532 | Olaparib | 3 |
| iGMDRD424 | Tamatinib | 1 |
| iGMDRD781 | Sirolimus | 2 |
| iGMDRD286 | Nsc 632839 | 4 |
| iGMDRD74 | Idarubicin | 3 |
| iGMDRD730 | Kahalalide F | 3 |
| iGMDRD246 | NPC26 | 2 |
| iGMDRD23 | Gossypol | 3 |
| iGMDRD444 | Tivantinib | 3 |
| iGMDRD138 | PX 12 | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CASP3
CLASSFICATION
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