CTBP2
Summary: This gene produces alternative transcripts encoding two distinct proteins. One protein is a transcriptional repressor, while the other isoform is a major component of specialized synapses known as synaptic ribbons. Both proteins contain a NAD+ binding domain similar to NAD+-dependent 2-hydroxyacid dehydrogenases. A portion of the 3' untranslated region was used to map this gene to chromosome 21q21.3; however, it was noted that similar loci elsewhere in the genome are likely. Blast analysis shows that this gene is present on chromosome 10. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Feb 2014].
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
OMIM IDMIM:602619 Ensembl IDEnsembl:ENSG00000175029 HGNC IDHGNC:HGNC:2495 PHARMGKB IDPA26996 Map Location10q26.13 | |||||
Gene Categories:
TRANSCRIPTION FACTOR BINDINGGO terms in CTBP2
Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| BP | IEA | GO:0006351 | transcription, DNA-templated |
| BP | TAS | GO:0008285 | negative regulation of cell proliferation |
| BP | TAS | GO:0019079 | viral genome replication |
| BP | ISS | GO:0045892 | negative regulation of transcription, DNA-templated |
| BP | IMP | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IMP | GO:0048386 | positive regulation of retinoic acid receptor signaling pathway |
Gene expression in normal tissue: CTBP2
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in CTBP2
Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa04310 | Wnt signaling pathway - Homo sapiens (human) |
| kegg | hsa04330 | Notch signaling pathway - Homo sapiens (human) |
| kegg | hsa05200 | Pathways in cancer - Homo sapiens (human) |
| kegg | hsa05220 | Chronic myeloid leukemia - Homo sapiens (human) |
| wikipathways | WP2064 | Neural Crest Differentiation |
| wikipathways | WP268 | Notch Signaling Pathway |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in CTBP2
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
|---|---|---|---|---|---|---|---|---|
| No matching records found | ||||||||
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