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RPS6KA6

Summary: This gene encodes a member of ribosomal S6 kinase family, serine-threonine protein kinases which are regulated by growth factors. The encoded protein may be distinct from other members of this family, however, as studies suggest it is not growth factor dependent and may not participate in the same signaling pathways. [provided by RefSeq, Jan 2010].

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Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
Nameribosomal protein S6 kinase A6 OMIM IDMIM:300303 Ensembl IDEnsembl:ENSG00000072133 HGNC IDHGNC:HGNC:10435 PHARMGKB IDPA34850 Map LocationXq21.1

Gene Categories:

DRUGGABLE GENOME KINASE SERINE THREONINE KINASE

GO terms in RPS6KA6

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Term Type	Evidence Type	GO Term ID	GO Des.
CC	IDA	GO:0001650	fibrillar center
CC	IDA	GO:0005634	nucleus
CC	TAS	GO:0005654	nucleoplasm
CC	IDA	GO:0005730	nucleolus
CC	IDA	GO:0005739	mitochondrion
CC	TAS	GO:0005829	cytosol

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Gene expression in normal tissue: RPS6KA6

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in RPS6KA6

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Database	Pathway ID	Pathway Des.
wikipathways	WP3915	Angiopoietin Like Protein 8 Regulatory Pathway
wikipathways	WP477	Cytoplasmic Ribosomal Proteins
wikipathways	WP481	Insulin Signaling
kegg	hsa04010	MAPK signaling pathway - Homo sapiens (human)
kegg	hsa04114	Oocyte meiosis - Homo sapiens (human)
kegg	hsa04150	mTOR signaling pathway - Homo sapiens (human)

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Gene-Drug: Aster Plot

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Drug ID	Drug Name	Model Num.
iGMDRD562	Navitoclax	3
iGMDRD506	Fedratinib	3
iGMDRD888	Compound 44	5
iGMDRD74	Idarubicin	3

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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in RPS6KA6

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	Model	Level	Reference ID	Tissue	Cancer	Drug	Clinical Response	Source
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