RPS6KA6
Summary: This gene encodes a member of ribosomal S6 kinase family, serine-threonine protein kinases which are regulated by growth factors. The encoded protein may be distinct from other members of this family, however, as studies suggest it is not growth factor dependent and may not participate in the same signaling pathways. [provided by RefSeq, Jan 2010].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| ribosomal protein S6 kinase A6 | MIM:300303 | Ensembl:ENSG00000072133 | HGNC:HGNC:10435 | PA34850 | Xq21.1 |
GO terms in RPS6KA6
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IDA | GO:0001650 | fibrillar center |
| CC | IDA | GO:0005634 | nucleus |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | IDA | GO:0005730 | nucleolus |
| CC | IDA | GO:0005739 | mitochondrion |
| CC | TAS | GO:0005829 | cytosol |
| BP | IEA | GO:0006468 | protein phosphorylation |
| BP | IMP | GO:0006978 | DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator |
| BP | TAS | GO:0007165 | signal transduction |
| BP | TAS | GO:0007417 | central nervous system development |
| BP | ISS | GO:0045992 | negative regulation of embryonic development |
| BP | ISS | GO:0070373 | negative regulation of ERK1 and ERK2 cascade |
| BP | ISS | GO:2000381 | negative regulation of mesoderm development |
| MF | IEA | GO:0000287 | magnesium ion binding |
| MF | TAS | GO:0004672 | protein kinase activity |
| MF | IBA | GO:0004711 | ribosomal protein S6 kinase activity |
| MF | IEA | GO:0005524 | ATP binding |
| MF | TAS | GO:0016301 | kinase activity |
Gene expression in normal tissue: RPS6KA6
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in RPS6KA6
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP3915 | Angiopoietin Like Protein 8 Regulatory Pathway |
| wikipathways | WP477 | Cytoplasmic Ribosomal Proteins |
| wikipathways | WP481 | Insulin Signaling |
| kegg | hsa04010 | MAPK signaling pathway - Homo sapiens (human) |
| kegg | hsa04114 | Oocyte meiosis - Homo sapiens (human) |
| kegg | hsa04150 | mTOR signaling pathway - Homo sapiens (human) |
| kegg | hsa04714 | Thermogenesis - Homo sapiens (human) |
| kegg | hsa04720 | Long-term potentiation - Homo sapiens (human) |
| kegg | hsa04722 | Neurotrophin signaling pathway - Homo sapiens (human) |
| kegg | hsa04914 | Progesterone-mediated oocyte maturation - Homo sapiens (human) |
| kegg | hsa04931 | Insulin resistance - Homo sapiens (human) |
| reactome | R-HSA-112314 | Neurotransmitter receptors and postsynaptic signal transmission |
| reactome | R-HSA-112315 | Transmission across Chemical Synapses |
| reactome | R-HSA-112316 | Neuronal System |
| reactome | R-HSA-1266738 | Developmental Biology |
| reactome | R-HSA-373760 | L1CAM interactions |
| reactome | R-HSA-422475 | Axon guidance |
| reactome | R-HSA-437239 | Recycling pathway of L1 |
| reactome | R-HSA-438064 | Post NMDA receptor activation events |
| reactome | R-HSA-442742 | CREB phosphorylation through the activation of Ras |
| reactome | R-HSA-442755 | Activation of NMDA receptor and postsynaptic events |
| reactome | R-HSA-444257 | RSK activation |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD562 | Navitoclax | 3 |
| iGMDRD506 | Fedratinib | 3 |
| iGMDRD888 | Compound 44 | 5 |
| iGMDRD74 | Idarubicin | 3 |
| iGMDRD100 | Zebularine | 2 |
| iGMDRD188 | Piperlongumine | 3 |
| iGMDRD451 | Serdemetan | 5 |
| iGMDRD64 | Parbendazole | 2 |
| iGMDRD255 | SB225002 | 1 |
| iGMDRD187 | BRD9876 | 5 |
| iGMDRD52 | Rotenone | 6 |
| iGMDRD71 | Sparfosic acid | 3 |
| iGMDRD446 | LY 2183240 | 2 |
| iGMDRD394 | BX-795 | 1 |
| iGMDRD466 | Chaetocin | 4 |
| iGMDRD772 | BRD4770 | 2 |
| iGMDRD420 | Leucascandrolide A | 5 |
| iGMDRD579 | PF750 | 3 |
| iGMDRD599 | Salermide | 5 |
| iGMDRD126 | Tipifarnib | 5 |
| iGMDRD494 | Neopeltolide | 3 |
| iGMDRD144 | NSC95397 | 2 |
| iGMDRD427 | ABT737 | 3 |
| iGMDRD662 | JQ-1 | 3 |
| iGMDRD872 | BRD7137 | 2 |
| iGMDRD322 | FK 866 | 3 |
| iGMDRD42 | Vorinostat | 3 |
| iGMDRD82 | Quiflapon | 3 |
| iGMDRD246 | NPC26 | 6 |
| iGMDRD263 | AACOCF3 | 4 |
| iGMDRD300 | Tozasertib | 2 |
| iGMDRD5 | Tyrphostin AG 1478 | 2 |
| iGMDRD137 | Indisulam | 2 |
| iGMDRD434 | BMS-536924 | 1 |
| iGMDRD289 | Parthenolide | 2 |
| iGMDRD6 | AM-580 | 3 |
| iGMDRD85 | Ursolic acid | 3 |
| iGMDRD945 | ML214 | 2 |
| iGMDRD123 | Isoevodiamine | 3 |
| iGMDRD512 | nutlin 3 | 3 |
| iGMDRD330 | BRD4132 | 6 |
| iGMDRD405 | PIK-75 | 3 |
| iGMDRD116 | CD437 | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in RPS6KA6
CLASSFICATION
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