ERCC5


Summary: This gene encodes a single-strand specific DNA endonuclease that makes the 3' incision in DNA excision repair following UV-induced damage. The protein may also function in other cellular processes, including RNA polymerase II transcription, and transcription-coupled DNA repair. Mutations in this gene cause xeroderma pigmentosum complementation group G (XP-G), which is also referred to as xeroderma pigmentosum VII (XP7), a skin disorder characterized by hypersensitivity to UV light and increased susceptibility for skin cancer development following UV exposure. Some patients also develop Cockayne syndrome, which is characterized by severe growth defects, cognitive disability, and cachexia. Read-through transcription exists between this gene and the neighboring upstream BIVM (basic, immunoglobulin-like variable motif containing) gene. [provided by RefSeq, Feb 2011].

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GO terms in ERCC5


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Term Type
Evidence Type
GO Term ID
GO Des.
CC IBA GO:0005634 nucleus
CC IDA GO:0005634 nucleus
CC TAS GO:0005654 nucleoplasm
CC IDA GO:0005662 DNA replication factor A complex
CC IDA GO:0005675 holo TFIIH complex
CC IDA GO:0016591 DNA-directed RNA polymerase II, holoenzyme
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Gene expression in normal tissue: ERCC5

16 tissues mixtureadiposeadrenalbrainbreastcolonheartkidneyliverlunglymph nodeovaryprostateskeletal muscletestesthyroidwhite blood cells

Gene-model tissue-cancer distribution: Bubble Plot

LUNtissue: LUN cancer: LUNG model num: 0LUNGtissue: LUNG cancer: undefined model num: 32BOWEtissue: BOWE cancer: BOWEL model num: 0BOWELtissue: BOWEL cancer: undefined model num: 20undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 38BLOOtissue: BLOO cancer: BLOOD model num: 0BLOODtissue: BLOOD cancer: undefined model num: 3

Gene-drug pathway distribution

undefined24Cell cycle2Biosynthesis of secondary metabolites2Protein stability and degradation2WNT signaling1RTK signaling1Metabolic pathways1p53 pathway1PI3K/MTOR signaling1DNA replication1

Pathways in ERCC5


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Database
Pathway ID
Pathway Des.
reactome R-HSA-5696395 Formation of Incision Complex in GG-NER
reactome R-HSA-5696398 Nucleotide Excision Repair
reactome R-HSA-5696399 Global Genome Nucleotide Excision Repair (GG-NER)
reactome R-HSA-5696400 Dual Incision in GG-NER
reactome R-HSA-6781827 Transcription-Coupled Nucleotide Excision Repair (TC-NER)
reactome R-HSA-6782135 Dual incision in TC-NER
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD137 Indisulam 3
iGMDRD121 GMX1778 2
iGMDRD158 NSC141540 3
iGMDRD267 Oligomycin A 3
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in ERCC5

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Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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