PAPPA

Summary: This gene encodes a secreted metalloproteinase which cleaves insulin-like growth factor binding proteins (IGFBPs). Following IGFBP cleavage, insulin growth factors dissociate from IGFBPs and bind to IGF receptors, resulting in activation of the IGF pathway. The encoded protein plays a role in bone formation, inflammation, wound healing and female fertility. Enhanced expression of this protein is associated with diabetic nephropathy in human patients and this protein may promote tumor invasion and growth in various human cancers. [provided by RefSeq, Aug 2017].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
Namepappalysin 1
OMIM IDMIM:176385
Ensembl IDEnsembl:ENSG00000182752
HGNC IDHGNC:HGNC:8602
PHARMGKB IDPA32935
Map Location9q33.1

GO terms in PAPPA


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Term Type
Evidence Type
GO Term ID
GO Des.
BP IEA GO:0006508 proteolysis
BP NAS GO:0007565 female pregnancy
BP IEA GO:0032354 response to follicle-stimulating hormone
BP TAS GO:0044267 cellular protein metabolic process
BP IEA GO:0051384 response to glucocorticoid
CC IDA GO:0005576 extracellular region
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Gene expression in normal tissue: PAPPA

16 tissues mixtureadiposeadrenalbrainbreastcolonheartkidneyliverlunglymph nodeovaryprostateskeletal muscletestesthyroidwhite blood cells

Gene-model tissue-cancer distribution: Bubble Plot

BLOOtissue: BLOO cancer: BLOOD model num: 0BLOODtissue: BLOOD cancer: undefined model num: 25undefinetissue: undefine cancer: undefined model num: 0undefinedtissue: undefined cancer: PANCAN model num: 26undefinedtissue: undefined cancer: SMALL_CELL_CARCINOMA model num: 11undefinedtissue: undefined cancer: ADENOCARCINOMA model num: 7undefinedtissue: undefined cancer: SQUAMOUS_CELL_CARCINOMA model num: 2BOWEtissue: BOWE cancer: BOWEL model num: 0BOWELtissue: BOWEL cancer: undefined model num: 9UTERUtissue: UTERU cancer: UTERUS model num: 0UTERUStissue: UTERUS cancer: Endometrial Carcinoma (UCEC) model num: 18LUNtissue: LUN cancer: LUNG model num: 0LUNGtissue: LUNG cancer: undefined model num: 6

Gene-drug pathway distribution

Pathways in PAPPA


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Database
Pathway ID
Pathway Des.
reactome R-HSA-381426 Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
reactome R-HSA-392499 Metabolism of proteins
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD434 BMS-536924 6
iGMDRD226 ML006 2
iGMDRD77 Itraconazole 3
iGMDRD138 PX 12 4
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in PAPPA

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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