FGF19


Summary: The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes including embryonic development cell growth, morphogenesis, tissue repair, tumor growth and invasion. This growth factor is a high affinity, heparin dependent ligand for FGFR4. Expression of this gene was detected only in fetal but not adult brain tissue. Synergistic interaction of the chick homolog and Wnt-8c has been shown to be required for initiation of inner ear development. [provided by RefSeq, Jul 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
fibroblast growth factor 19MIM:603891Ensembl:ENSG00000162344HGNC:HGNC:3675PA2811411q13.3

GO terms in FGF19


Term TypeEvidence TypeGO Term IDGO Des.
CCTASGO:0005576extracellular region
CCIEAGO:0005622intracellular
BPTASGO:0000165MAPK cascade
BPIEAGO:0001755neural crest cell migration
BPIDAGO:0001934positive regulation of protein phosphorylation
BPTASGO:0007399nervous system development
BPIEAGO:0007507heart development
BPIGIGO:0008284positive regulation of cell proliferation
BPIGIGO:0008543fibroblast growth factor receptor signaling pathway
BPIPIGO:0008543fibroblast growth factor receptor signaling pathway
BPTASGO:0008543fibroblast growth factor receptor signaling pathway
BPIEAGO:0010469regulation of signaling receptor activity
BPIDAGO:0010629negative regulation of gene expression
BPIEAGO:0036092phosphatidylinositol-3-phosphate biosynthetic process
BPIDAGO:0046326positive regulation of glucose import
BPIDAGO:0046330positive regulation of JNK cascade
BPIEAGO:0046854phosphatidylinositol phosphorylation
BPTASGO:0051897positive regulation of protein kinase B signaling
BPIDAGO:0070374positive regulation of ERK1 and ERK2 cascade
BPIDAGO:0070858negative regulation of bile acid biosynthetic process
MFTASGO:0005088Ras guanyl-nucleotide exchange factor activity
MFIPIGO:0005104fibroblast growth factor receptor binding
MFIPIGO:0005515protein binding
MFIEAGO:0008083growth factor activity
MFTASGO:00163031-phosphatidylinositol-3-kinase activity
MFTASGO:0046934phosphatidylinositol-4,5-bisphosphate 3-kinase activity

Gene expression in normal tissue: FGF19

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in FGF19


DatabasePathway IDPathway Des.
reactomeR-HSA-109704PI3K Cascade
reactomeR-HSA-112399IRS-mediated signalling
reactomeR-HSA-1257604PIP3 activates AKT signaling
reactomeR-HSA-1307965betaKlotho-mediated ligand binding
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-1643685Disease
reactomeR-HSA-190236Signaling by FGFR
reactomeR-HSA-190322FGFR4 ligand binding and activation
reactomeR-HSA-199418Negative regulation of the PI3K/AKT network
reactomeR-HSA-2219528PI3K/AKT Signaling in Cancer
reactomeR-HSA-2219530Constitutive Signaling by Aberrant PI3K in Cancer
reactomeR-HSA-2404192Signaling by Type 1 Insulin-like Growth Factor 1 Receptor (IGF1R)
reactomeR-HSA-2428924IGF1R signaling cascade
reactomeR-HSA-2428928IRS-related events triggered by IGF1R
reactomeR-HSA-5654228Phospholipase C-mediated cascade; FGFR4
reactomeR-HSA-5654712FRS-mediated FGFR4 signaling
reactomeR-HSA-5654716Downstream signaling of activated FGFR4
reactomeR-HSA-5654719SHC-mediated cascade:FGFR4
reactomeR-HSA-5654720PI-3K cascade:FGFR4
reactomeR-HSA-5654733Negative regulation of FGFR4 signaling
reactomeR-HSA-5654743Signaling by FGFR4
reactomeR-HSA-5663202Diseases of signal transduction
reactomeR-HSA-5673001RAF/MAP kinase cascade
reactomeR-HSA-5683057MAPK family signaling cascades
reactomeR-HSA-5684996MAPK1/MAPK3 signaling
reactomeR-HSA-6811558PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling
reactomeR-HSA-74751Insulin receptor signalling cascade
reactomeR-HSA-74752Signaling by Insulin receptor
reactomeR-HSA-9006925Intracellular signaling by second messengers
reactomeR-HSA-9006934Signaling by Receptor Tyrosine Kinases
wikipathwaysWP2064Neural Crest Differentiation
wikipathwaysWP2879Farnesoid X Receptor Pathway
wikipathwaysWP2882Nuclear Receptors Meta-Pathway
wikipathwaysWP382MAPK Signaling Pathway
wikipathwaysWP3931ESC Pluripotency Pathways
wikipathwaysWP3932Focal Adhesion-PI3K-Akt-mTOR-signaling pathway
wikipathwaysWP4172PI3K-Akt Signaling Pathway
wikipathwaysWP51Regulation of Actin Cytoskeleton
kegghsa04010MAPK signaling pathway - Homo sapiens (human)
kegghsa04014Ras signaling pathway - Homo sapiens (human)
kegghsa04015Rap1 signaling pathway - Homo sapiens (human)
kegghsa04151PI3K-Akt signaling pathway - Homo sapiens (human)
kegghsa04810Regulation of actin cytoskeleton - Homo sapiens (human)
kegghsa05200Pathways in cancer - Homo sapiens (human)
kegghsa05218Melanoma - Homo sapiens (human)
kegghsa05224Breast cancer - Homo sapiens (human)
kegghsa05226Gastric cancer - Homo sapiens (human)
pidfgf_pathwayFGF signaling pathway
pidsyndecan_1_pathwaySyndecan-1-mediated signaling events
pidsyndecan_2_pathwaySyndecan-2-mediated signaling events
pidsyndecan_3_pathwaySyndecan-3-mediated signaling events

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD158NSC1415402
iGMDRD271Brefeldin A1
iGMDRD74Idarubicin1
iGMDRD329Merck601
iGMDRD506Fedratinib4
iGMDRD60Quinoclamine1
iGMDRD369TGX-1153
iGMDRD23Gossypol3
iGMDRD126Tipifarnib3
iGMDRD1008SR-II-138A1
iGMDRD599Salermide1
iGMDRD512nutlin 33
iGMDRD144NSC953972
iGMDRD560MK-22063
iGMDRD652UNC06383
iGMDRD237ABT-7513
iGMDRD314Tanespimycin5
iGMDRD123Isoevodiamine1
iGMDRD177Teniposide6

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in FGF19

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