NUP214


Summary: The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins are the main components of the nuclear pore complex in eukaryotic cells. This gene is a member of the FG-repeat-containing nucleoporins. The protein encoded by this gene is localized to the cytoplasmic face of the nuclear pore complex where it is required for proper cell cycle progression and nucleocytoplasmic transport. The 3' portion of this gene forms a fusion gene with the DEK gene on chromosome 6 in a t(6,9) translocation associated with acute myeloid leukemia and myelodysplastic syndrome. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
nucleoporin 214MIM:114350Ensembl:ENSG00000126883HGNC:HGNC:8064PA318519q34.13

GO terms in NUP214


Term TypeEvidence TypeGO Term IDGO Des.
CCIDAGO:0005634nucleus
CCIBAGO:0005643nuclear pore
CCTASGO:0005654nucleoplasm
CCTASGO:0005829cytosol
CCIDAGO:0005925focal adhesion
CCIDAGO:0043231intracellular membrane-bounded organelle
CCIBAGO:0044613nuclear pore central transport channel
CCIBAGO:0044615nuclear pore nuclear basket
CCIDAGO:1990876cytoplasmic side of nuclear pore
BPIBAGO:0006405RNA export from nucleus
BPIMPGO:0006406mRNA export from nucleus
BPTASGO:0006406mRNA export from nucleus
BPIBAGO:0006606protein import into nucleus
BPIMPGO:0006611protein export from nucleus
BPTASGO:0016032viral process
BPTASGO:0043488regulation of mRNA stability
BPIMPGO:0046822regulation of nucleocytoplasmic transport
BPIEAGO:0051726regulation of cell cycle
MFIDAGO:0005049nuclear export signal receptor activity
MFIPIGO:0005515protein binding
MFIBAGO:0008139nuclear localization sequence binding
MFIBAGO:0017056structural constituent of nuclear pore

Gene expression in normal tissue: NUP214

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in NUP214


DatabasePathway IDPathway Des.
wikipathwaysWP366TGF-beta Signaling Pathway
pidbmppathwayBMP receptor signaling
pidhdac_classi_pathwaySignaling events mediated by HDAC Class I
pidhdac_classii_pathwaySignaling events mediated by HDAC Class II
pidnfat_3pathwayRole of Calcineurin-dependent NFAT signaling in lymphocytes
pidranbp2pathwaySumoylation by RanBP2 regulates transcriptional repression
pidsmad2_3pathwayRegulation of cytoplasmic and nuclear SMAD2/3 signaling
kegghsa03013RNA transport - Homo sapiens (human)
kegghsa05169Epstein-Barr virus infection - Homo sapiens (human)
netpathPathway_TGF_beta_ReceptorTGF_beta_Receptor
biocartanpcpathwaymechanism of protein import into the nucleus
biocartaranbp2pathwaysumoylation by ranbp2 regulates transcriptional repression
biocartaranpathwaycycling of ran in nucleocytoplasmic transport
reactomeR-HSA-1169408ISG15 antiviral mechanism
reactomeR-HSA-1169410Antiviral mechanism by IFN-stimulated genes
reactomeR-HSA-1280215Cytokine Signaling in Immune system
reactomeR-HSA-1430728Metabolism
reactomeR-HSA-159227Transport of the SLBP independent Mature mRNA
reactomeR-HSA-159230Transport of the SLBP Dependant Mature mRNA
reactomeR-HSA-159231Transport of Mature mRNA Derived from an Intronless Transcript
reactomeR-HSA-159234Transport of Mature mRNAs Derived from Intronless Transcripts
reactomeR-HSA-159236Transport of Mature mRNA derived from an Intron-Containing Transcript
reactomeR-HSA-162587HIV Life Cycle
reactomeR-HSA-162599Late Phase of HIV Life Cycle
reactomeR-HSA-162906HIV Infection
reactomeR-HSA-162906HIV Infection
reactomeR-HSA-162909Host Interactions of HIV factors
reactomeR-HSA-162909Host Interactions of HIV factors
reactomeR-HSA-1640170Cell Cycle
reactomeR-HSA-1643685Disease
reactomeR-HSA-1643685Disease
reactomeR-HSA-165054Rev-mediated nuclear export of HIV RNA
reactomeR-HSA-168253Host Interactions with Influenza Factors
reactomeR-HSA-168254Influenza Infection
reactomeR-HSA-168255Influenza Life Cycle
reactomeR-HSA-168256Immune System
reactomeR-HSA-168271Transport of Ribonucleoproteins into the Host Nucleus
reactomeR-HSA-168273Influenza Viral RNA Transcription and Replication
reactomeR-HSA-168274Export of Viral Ribonucleoproteins from Nucleus
reactomeR-HSA-168276NS1 Mediated Effects on Host Pathways
reactomeR-HSA-168325Viral Messenger RNA Synthesis
reactomeR-HSA-168333NEP/NS2 Interacts with the Cellular Export Machinery
reactomeR-HSA-170822Regulation of Glucokinase by Glucokinase Regulatory Protein
reactomeR-HSA-176033Interactions of Vpr with host cellular proteins
reactomeR-HSA-177243Interactions of Rev with host cellular proteins
reactomeR-HSA-177243Interactions of Rev with host cellular proteins
reactomeR-HSA-180746Nuclear import of Rev protein
reactomeR-HSA-180910Vpr-mediated nuclear import of PICs
reactomeR-HSA-191859snRNP Assembly
reactomeR-HSA-194441Metabolism of non-coding RNA
reactomeR-HSA-211000Gene Silencing by RNA
reactomeR-HSA-2262752Cellular responses to stress
reactomeR-HSA-2980766Nuclear Envelope Breakdown
reactomeR-HSA-2990846SUMOylation
reactomeR-HSA-2990846SUMOylation
reactomeR-HSA-3108214SUMOylation of DNA damage response and repair proteins
reactomeR-HSA-3108232SUMO E3 ligases SUMOylate target proteins
reactomeR-HSA-3108232SUMO E3 ligases SUMOylate target proteins
reactomeR-HSA-3232142SUMOylation of ubiquitinylation proteins
reactomeR-HSA-3301854Nuclear Pore Complex (NPC) Disassembly
reactomeR-HSA-3371453Regulation of HSF1-mediated heat shock response
reactomeR-HSA-3371556Cellular response to heat stress
reactomeR-HSA-392499Metabolism of proteins
reactomeR-HSA-392499Metabolism of proteins
reactomeR-HSA-4085377SUMOylation of SUMOylation proteins
reactomeR-HSA-450520HuR (ELAVL1) binds and stabilizes mRNA
reactomeR-HSA-450531Regulation of mRNA stability by proteins that bind AU-rich elements
reactomeR-HSA-4551638SUMOylation of chromatin organization proteins
reactomeR-HSA-4570464SUMOylation of RNA binding proteins
reactomeR-HSA-4615885SUMOylation of DNA replication proteins
reactomeR-HSA-4615885SUMOylation of DNA replication proteins
reactomeR-HSA-5578749Transcriptional regulation by small RNAs
reactomeR-HSA-5663205Infectious disease
reactomeR-HSA-5663205Infectious disease
reactomeR-HSA-597592Post-translational protein modification
reactomeR-HSA-597592Post-translational protein modification
reactomeR-HSA-6784531tRNA processing in the nucleus
reactomeR-HSA-68875Mitotic Prophase
reactomeR-HSA-68886M Phase
reactomeR-HSA-69278Cell Cycle, Mitotic
reactomeR-HSA-70171Glycolysis
reactomeR-HSA-70326Glucose metabolism
reactomeR-HSA-71387Metabolism of carbohydrates
reactomeR-HSA-72202Transport of Mature Transcript to Cytoplasm
reactomeR-HSA-72203Processing of Capped Intron-Containing Pre-mRNA
reactomeR-HSA-72306tRNA processing
reactomeR-HSA-74160Gene expression (Transcription)
reactomeR-HSA-8953854Metabolism of RNA
reactomeR-HSA-8953897Cellular responses to external stimuli
reactomeR-HSA-913531Interferon Signaling

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD126Tipifarnib4
iGMDRD433Lexibulin2
iGMDRD151CHM-13
iGMDRD599Salermide2
iGMDRD387CHIR-990211
iGMDRD772BRD47703
iGMDRD420Leucascandrolide A2
iGMDRD546BMS-7548075
iGMDRD670ML 2103
iGMDRD494Neopeltolide3
iGMDRD270Ciclosporin1
iGMDRD138PX 122
iGMDRD260FQI-22
iGMDRD782DC-45-A22
iGMDRD187BRD98764
iGMDRD870BRD636103
iGMDRD100Zebularine2
iGMDRD74Idarubicin3
iGMDRD577BIX012947
iGMDRD60Quinoclamine2
iGMDRD512nutlin 32
iGMDRD584VER 1550081
iGMDRD424Tamatinib3
iGMDRD57Chloropentafluorobenzene5
iGMDRD211(1S,3R)-RSL33
iGMDRD154NSC237664
iGMDRD132(-)-gallocatechin-3-O-gallate5
iGMDRD158NSC1415401
iGMDRD271Brefeldin A2
iGMDRD6AM-5802
iGMDRD705Nakiterpiosin3
iGMDRD434BMS-5369242
iGMDRD77Itraconazole5
iGMDRD871BRD63682
iGMDRD329Merck607
iGMDRD300Tozasertib3

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in NUP214

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