NUP214
Summary: The nuclear pore complex is a massive structure that extends across the nuclear envelope, forming a gateway that regulates the flow of macromolecules between the nucleus and the cytoplasm. Nucleoporins are the main components of the nuclear pore complex in eukaryotic cells. This gene is a member of the FG-repeat-containing nucleoporins. The protein encoded by this gene is localized to the cytoplasmic face of the nuclear pore complex where it is required for proper cell cycle progression and nucleocytoplasmic transport. The 3' portion of this gene forms a fusion gene with the DEK gene on chromosome 6 in a t(6,9) translocation associated with acute myeloid leukemia and myelodysplastic syndrome. Alternative splicing of this gene results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| nucleoporin 214 | MIM:114350 | Ensembl:ENSG00000126883 | HGNC:HGNC:8064 | PA31851 | 9q34.13 |
GO terms in NUP214
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IDA | GO:0005634 | nucleus |
| CC | IBA | GO:0005643 | nuclear pore |
| CC | TAS | GO:0005654 | nucleoplasm |
| CC | TAS | GO:0005829 | cytosol |
| CC | IDA | GO:0005925 | focal adhesion |
| CC | IDA | GO:0043231 | intracellular membrane-bounded organelle |
| CC | IBA | GO:0044613 | nuclear pore central transport channel |
| CC | IBA | GO:0044615 | nuclear pore nuclear basket |
| CC | IDA | GO:1990876 | cytoplasmic side of nuclear pore |
| BP | IBA | GO:0006405 | RNA export from nucleus |
| BP | IMP | GO:0006406 | mRNA export from nucleus |
| BP | TAS | GO:0006406 | mRNA export from nucleus |
| BP | IBA | GO:0006606 | protein import into nucleus |
| BP | IMP | GO:0006611 | protein export from nucleus |
| BP | TAS | GO:0016032 | viral process |
| BP | TAS | GO:0043488 | regulation of mRNA stability |
| BP | IMP | GO:0046822 | regulation of nucleocytoplasmic transport |
| BP | IEA | GO:0051726 | regulation of cell cycle |
| MF | IDA | GO:0005049 | nuclear export signal receptor activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IBA | GO:0008139 | nuclear localization sequence binding |
| MF | IBA | GO:0017056 | structural constituent of nuclear pore |
Gene expression in normal tissue: NUP214
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in NUP214
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP366 | TGF-beta Signaling Pathway |
| pid | bmppathway | BMP receptor signaling |
| pid | hdac_classi_pathway | Signaling events mediated by HDAC Class I |
| pid | hdac_classii_pathway | Signaling events mediated by HDAC Class II |
| pid | nfat_3pathway | Role of Calcineurin-dependent NFAT signaling in lymphocytes |
| pid | ranbp2pathway | Sumoylation by RanBP2 regulates transcriptional repression |
| pid | smad2_3pathway | Regulation of cytoplasmic and nuclear SMAD2/3 signaling |
| kegg | hsa03013 | RNA transport - Homo sapiens (human) |
| kegg | hsa05169 | Epstein-Barr virus infection - Homo sapiens (human) |
| netpath | Pathway_TGF_beta_Receptor | TGF_beta_Receptor |
| biocarta | npcpathway | mechanism of protein import into the nucleus |
| biocarta | ranbp2pathway | sumoylation by ranbp2 regulates transcriptional repression |
| biocarta | ranpathway | cycling of ran in nucleocytoplasmic transport |
| reactome | R-HSA-1169408 | ISG15 antiviral mechanism |
| reactome | R-HSA-1169410 | Antiviral mechanism by IFN-stimulated genes |
| reactome | R-HSA-1280215 | Cytokine Signaling in Immune system |
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-159227 | Transport of the SLBP independent Mature mRNA |
| reactome | R-HSA-159230 | Transport of the SLBP Dependant Mature mRNA |
| reactome | R-HSA-159231 | Transport of Mature mRNA Derived from an Intronless Transcript |
| reactome | R-HSA-159234 | Transport of Mature mRNAs Derived from Intronless Transcripts |
| reactome | R-HSA-159236 | Transport of Mature mRNA derived from an Intron-Containing Transcript |
| reactome | R-HSA-162587 | HIV Life Cycle |
| reactome | R-HSA-162599 | Late Phase of HIV Life Cycle |
| reactome | R-HSA-162906 | HIV Infection |
| reactome | R-HSA-162906 | HIV Infection |
| reactome | R-HSA-162909 | Host Interactions of HIV factors |
| reactome | R-HSA-162909 | Host Interactions of HIV factors |
| reactome | R-HSA-1640170 | Cell Cycle |
| reactome | R-HSA-1643685 | Disease |
| reactome | R-HSA-1643685 | Disease |
| reactome | R-HSA-165054 | Rev-mediated nuclear export of HIV RNA |
| reactome | R-HSA-168253 | Host Interactions with Influenza Factors |
| reactome | R-HSA-168254 | Influenza Infection |
| reactome | R-HSA-168255 | Influenza Life Cycle |
| reactome | R-HSA-168256 | Immune System |
| reactome | R-HSA-168271 | Transport of Ribonucleoproteins into the Host Nucleus |
| reactome | R-HSA-168273 | Influenza Viral RNA Transcription and Replication |
| reactome | R-HSA-168274 | Export of Viral Ribonucleoproteins from Nucleus |
| reactome | R-HSA-168276 | NS1 Mediated Effects on Host Pathways |
| reactome | R-HSA-168325 | Viral Messenger RNA Synthesis |
| reactome | R-HSA-168333 | NEP/NS2 Interacts with the Cellular Export Machinery |
| reactome | R-HSA-170822 | Regulation of Glucokinase by Glucokinase Regulatory Protein |
| reactome | R-HSA-176033 | Interactions of Vpr with host cellular proteins |
| reactome | R-HSA-177243 | Interactions of Rev with host cellular proteins |
| reactome | R-HSA-177243 | Interactions of Rev with host cellular proteins |
| reactome | R-HSA-180746 | Nuclear import of Rev protein |
| reactome | R-HSA-180910 | Vpr-mediated nuclear import of PICs |
| reactome | R-HSA-191859 | snRNP Assembly |
| reactome | R-HSA-194441 | Metabolism of non-coding RNA |
| reactome | R-HSA-211000 | Gene Silencing by RNA |
| reactome | R-HSA-2262752 | Cellular responses to stress |
| reactome | R-HSA-2980766 | Nuclear Envelope Breakdown |
| reactome | R-HSA-2990846 | SUMOylation |
| reactome | R-HSA-2990846 | SUMOylation |
| reactome | R-HSA-3108214 | SUMOylation of DNA damage response and repair proteins |
| reactome | R-HSA-3108232 | SUMO E3 ligases SUMOylate target proteins |
| reactome | R-HSA-3108232 | SUMO E3 ligases SUMOylate target proteins |
| reactome | R-HSA-3232142 | SUMOylation of ubiquitinylation proteins |
| reactome | R-HSA-3301854 | Nuclear Pore Complex (NPC) Disassembly |
| reactome | R-HSA-3371453 | Regulation of HSF1-mediated heat shock response |
| reactome | R-HSA-3371556 | Cellular response to heat stress |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-4085377 | SUMOylation of SUMOylation proteins |
| reactome | R-HSA-450520 | HuR (ELAVL1) binds and stabilizes mRNA |
| reactome | R-HSA-450531 | Regulation of mRNA stability by proteins that bind AU-rich elements |
| reactome | R-HSA-4551638 | SUMOylation of chromatin organization proteins |
| reactome | R-HSA-4570464 | SUMOylation of RNA binding proteins |
| reactome | R-HSA-4615885 | SUMOylation of DNA replication proteins |
| reactome | R-HSA-4615885 | SUMOylation of DNA replication proteins |
| reactome | R-HSA-5578749 | Transcriptional regulation by small RNAs |
| reactome | R-HSA-5663205 | Infectious disease |
| reactome | R-HSA-5663205 | Infectious disease |
| reactome | R-HSA-597592 | Post-translational protein modification |
| reactome | R-HSA-597592 | Post-translational protein modification |
| reactome | R-HSA-6784531 | tRNA processing in the nucleus |
| reactome | R-HSA-68875 | Mitotic Prophase |
| reactome | R-HSA-68886 | M Phase |
| reactome | R-HSA-69278 | Cell Cycle, Mitotic |
| reactome | R-HSA-70171 | Glycolysis |
| reactome | R-HSA-70326 | Glucose metabolism |
| reactome | R-HSA-71387 | Metabolism of carbohydrates |
| reactome | R-HSA-72202 | Transport of Mature Transcript to Cytoplasm |
| reactome | R-HSA-72203 | Processing of Capped Intron-Containing Pre-mRNA |
| reactome | R-HSA-72306 | tRNA processing |
| reactome | R-HSA-74160 | Gene expression (Transcription) |
| reactome | R-HSA-8953854 | Metabolism of RNA |
| reactome | R-HSA-8953897 | Cellular responses to external stimuli |
| reactome | R-HSA-913531 | Interferon Signaling |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD126 | Tipifarnib | 4 |
| iGMDRD433 | Lexibulin | 2 |
| iGMDRD151 | CHM-1 | 3 |
| iGMDRD599 | Salermide | 2 |
| iGMDRD387 | CHIR-99021 | 1 |
| iGMDRD772 | BRD4770 | 3 |
| iGMDRD420 | Leucascandrolide A | 2 |
| iGMDRD546 | BMS-754807 | 5 |
| iGMDRD670 | ML 210 | 3 |
| iGMDRD494 | Neopeltolide | 3 |
| iGMDRD270 | Ciclosporin | 1 |
| iGMDRD138 | PX 12 | 2 |
| iGMDRD260 | FQI-2 | 2 |
| iGMDRD782 | DC-45-A2 | 2 |
| iGMDRD187 | BRD9876 | 4 |
| iGMDRD870 | BRD63610 | 3 |
| iGMDRD100 | Zebularine | 2 |
| iGMDRD74 | Idarubicin | 3 |
| iGMDRD577 | BIX01294 | 7 |
| iGMDRD60 | Quinoclamine | 2 |
| iGMDRD512 | nutlin 3 | 2 |
| iGMDRD584 | VER 155008 | 1 |
| iGMDRD424 | Tamatinib | 3 |
| iGMDRD57 | Chloropentafluorobenzene | 5 |
| iGMDRD211 | (1S,3R)-RSL3 | 3 |
| iGMDRD154 | NSC23766 | 4 |
| iGMDRD132 | (-)-gallocatechin-3-O-gallate | 5 |
| iGMDRD158 | NSC141540 | 1 |
| iGMDRD271 | Brefeldin A | 2 |
| iGMDRD6 | AM-580 | 2 |
| iGMDRD705 | Nakiterpiosin | 3 |
| iGMDRD434 | BMS-536924 | 2 |
| iGMDRD77 | Itraconazole | 5 |
| iGMDRD871 | BRD6368 | 2 |
| iGMDRD329 | Merck60 | 7 |
| iGMDRD300 | Tozasertib | 3 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in NUP214
CLASSFICATION
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