GO terms in RPS6KA5


Term TypeEvidence TypeGO Term IDGO Des.
MFIEAGO:0000287magnesium ion binding
MFIDAGO:0004672protein kinase activity
MFEXPGO:0004674protein serine/threonine kinase activity
MFIBAGO:0004674protein serine/threonine kinase activity
MFIDAGO:0004674protein serine/threonine kinase activity
MFIMPGO:0004674protein serine/threonine kinase activity
MFTASGO:0004674protein serine/threonine kinase activity
MFIPIGO:0005515protein binding
MFIDAGO:0005524ATP binding
CCIBAGO:0005634nucleus
CCIDAGO:0005634nucleus
CCIMPGO:0005634nucleus
CCIDAGO:0005654nucleoplasm
CCTASGO:0005654nucleoplasm
CCIBAGO:0005737cytoplasm
CCIDAGO:0005737cytoplasm
BPTASGO:0001818negative regulation of cytokine production
BPTASGO:0002223stimulatory C-type lectin receptor signaling pathway
BPIDAGO:0006355regulation of transcription, DNA-templated
BPIMPGO:0006355regulation of transcription, DNA-templated
BPIBAGO:0006468protein phosphorylation
BPIDAGO:0006468protein phosphorylation
BPIEAGO:0006954inflammatory response
BPTASGO:0007173epidermal growth factor receptor signaling pathway
BPTASGO:0007411axon guidance
BPIDAGO:0016572histone phosphorylation
BPTASGO:0016572histone phosphorylation
BPTASGO:0032793positive regulation of CREB transcription factor activity
BPIMPGO:0033129positive regulation of histone phosphorylation
BPIMPGO:0035066positive regulation of histone acetylation
BPIBAGO:0035556intracellular signal transduction
BPIDAGO:0035556intracellular signal transduction
BPIMPGO:0043987histone H3-S10 phosphorylation
BPIMPGO:0043988histone H3-S28 phosphorylation
BPIDAGO:0043990histone H2A-S1 phosphorylation
BPIDAGO:0045892negative regulation of transcription, DNA-templated
BPIMPGO:0045944positive regulation of transcription by RNA polymerase II
BPIMPGO:0051092positive regulation of NF-kappaB transcription factor activity
BPIMPGO:0070498interleukin-1-mediated signaling pathway

Gene expression in normal tissue: RPS6KA5

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in RPS6KA5


DatabasePathway IDPathway Des.
reactomeR-HSA-1266738Developmental Biology
reactomeR-HSA-1266738Developmental Biology
reactomeR-HSA-1280215Cytokine Signaling in Immune system
reactomeR-HSA-162582Signal Transduction
reactomeR-HSA-166016Toll Like Receptor 4 (TLR4) Cascade
reactomeR-HSA-166058MyD88:Mal cascade initiated on plasma membrane
reactomeR-HSA-166166MyD88-independent TLR4 cascade
reactomeR-HSA-166520Signaling by NTRKs
reactomeR-HSA-168138Toll Like Receptor 9 (TLR9) Cascade
reactomeR-HSA-168142Toll Like Receptor 10 (TLR10) Cascade
reactomeR-HSA-168164Toll Like Receptor 3 (TLR3) Cascade
reactomeR-HSA-168176Toll Like Receptor 5 (TLR5) Cascade
reactomeR-HSA-168179Toll Like Receptor TLR1:TLR2 Cascade
reactomeR-HSA-168181Toll Like Receptor 7/8 (TLR7/8) Cascade
reactomeR-HSA-168188Toll Like Receptor TLR6:TLR2 Cascade
reactomeR-HSA-168249Innate Immune System
reactomeR-HSA-168256Immune System
reactomeR-HSA-168898Toll-Like Receptors Cascades
reactomeR-HSA-181438Toll Like Receptor 2 (TLR2) Cascade
reactomeR-HSA-187037Signaling by NTRK1 (TRKA)
reactomeR-HSA-198725Nuclear Events (kinase and transcription factor activation)
reactomeR-HSA-198753ERK/MAPK targets
reactomeR-HSA-199920CREB phosphorylation
reactomeR-HSA-373760L1CAM interactions
reactomeR-HSA-375165NCAM signaling for neurite out-growth
reactomeR-HSA-422475Axon guidance
reactomeR-HSA-422475Axon guidance
reactomeR-HSA-437239Recycling pathway of L1
reactomeR-HSA-448424Interleukin-17 signaling
reactomeR-HSA-449147Signaling by Interleukins
reactomeR-HSA-450282MAPK targets/ Nuclear events mediated by MAP kinases
reactomeR-HSA-450294MAP kinase activation
reactomeR-HSA-5621481C-type lectin receptors (CLRs)
reactomeR-HSA-5621575CD209 (DC-SIGN) signaling
reactomeR-HSA-9006934Signaling by Receptor Tyrosine Kinases
reactomeR-HSA-937061TRIF(TICAM1)-mediated TLR4 signaling
reactomeR-HSA-975138TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation
reactomeR-HSA-975155MyD88 dependent cascade initiated on endosome
reactomeR-HSA-975871MyD88 cascade initiated on plasma membrane
biocartacrebpathwaytranscription factor creb and its extracellular signals
biocartaerkpathwayerk1/erk2 mapk signaling pathway
biocartap38mapkpathwayp38 mapk signaling pathway
netpathPathway_EGFR1EGFR1
netpathPathway_TNFalphaTNFalpha
piderbb1_downstream_pathwayErbB1 downstream signaling
pidlpa4_pathwayLPA4-mediated signaling events
pidmapktrkpathwayTrk receptor signaling mediated by the MAPK pathway
pidp38alphabetadownstreampathwaySignaling mediated by p38-alpha and p38-beta
kegghsa04010MAPK signaling pathway - Homo sapiens (human)
kegghsa04261Adrenergic signaling in cardiomyocytes - Homo sapiens (human)
kegghsa04668TNF signaling pathway - Homo sapiens (human)
kegghsa04713Circadian entrainment - Homo sapiens (human)
kegghsa04722Neurotrophin signaling pathway - Homo sapiens (human)
kegghsa05200Pathways in cancer - Homo sapiens (human)
kegghsa05206MicroRNAs in cancer - Homo sapiens (human)
kegghsa05219Bladder cancer - Homo sapiens (human)
wikipathwaysWP2380Brain-Derived Neurotrophic Factor (BDNF) signaling pathway
wikipathwaysWP2637Structural Pathway of Interleukin 1 (IL-1)
wikipathwaysWP2828Bladder Cancer
wikipathwaysWP382MAPK Signaling Pathway
wikipathwaysWP3853ERK Pathway in Huntington,s Disease
wikipathwaysWP3888VEGFA-VEGFR2 Signaling Pathway
wikipathwaysWP3915Angiopoietin Like Protein 8 Regulatory Pathway
wikipathwaysWP400p38 MAPK Signaling Pathway
wikipathwaysWP437EGF-EGFR Signaling Pathway
wikipathwaysWP481Insulin Signaling
wikipathwaysWP585Interferon type I signaling pathways
wikipathwaysWP722Serotonin HTR1 Group and FOS Pathway
wikipathwaysWP734Serotonin Receptor 4-6-7 and NR3C Signaling

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD512nutlin 33
iGMDRD387CHIR-990212
iGMDRD889Compound 7d-cis3
iGMDRD483SCH-5290742
iGMDRD494Neopeltolide2
iGMDRD405PIK-753
iGMDRD583LDN 1931891
iGMDRD781Sirolimus5
iGMDRD446LY 21832402
iGMDRD314Tanespimycin1
iGMDRD748PHA-6657522
iGMDRD375GW-4058332
iGMDRD154NSC237662
iGMDRD121GMX17782
iGMDRD158NSC1415402
iGMDRD8024-methylfasudil5
iGMDRD187BRD98761
iGMDRD870BRD636106
iGMDRD52Rotenone2
iGMDRD267Oligomycin A3
iGMDRD286Nsc 6328393
iGMDRD74Idarubicin1
iGMDRD506Fedratinib3
iGMDRD329Merck602
iGMDRD398Sepantronium2
iGMDRD886Compound 1541A6
iGMDRD300Tozasertib3
iGMDRD60Quinoclamine3
iGMDRD451Serdemetan2

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in RPS6KA5

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