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TTBK2

Summary: This gene encodes a serine-threonine kinase that putatively phosphorylates tau and tubulin proteins. Mutations in this gene cause spinocerebellar ataxia type 11 (SCA11); a neurodegenerative disease characterized by progressive ataxia and atrophy of the cerebellum and brainstem. [provided by RefSeq, Aug 2009].

Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
tau tubulin kinase 2	MIM:611695	Ensembl:ENSG00000128881	HGNC:HGNC:19141	PA134913925	15q15.2

Gene Categories:

DRUGGABLE GENOME KINASE SERINE THREONINE KINASE

GO terms in TTBK2

Term Type	Evidence Type	GO Term ID	GO Des.
MF	IDA	GO:0004672	protein kinase activity
MF	IBA	GO:0004674	protein serine/threonine kinase activity
MF	IDA	GO:0004674	protein serine/threonine kinase activity
MF	NAS	GO:0004674	protein serine/threonine kinase activity
MF	IPI	GO:0005515	protein binding
MF	IEA	GO:0005524	ATP binding
MF	IPI	GO:0019894	kinesin binding
MF	TAS	GO:0050321	tau-protein kinase activity
MF	TAS	GO:0051010	microtubule plus-end binding
CC	HDA	GO:0005615	extracellular space
CC	IBA	GO:0005634	nucleus
CC	IDA	GO:0005634	nucleus
CC	IBA	GO:0005737	cytoplasm
CC	IDA	GO:0005814	centriole
CC	IDA	GO:0005829	cytosol
CC	TAS	GO:0005829	cytosol
CC	IDA	GO:0035869	ciliary transition zone
CC	ISS	GO:0035869	ciliary transition zone
CC	ISS	GO:0036064	ciliary basal body
BP	IGI	GO:0000226	microtubule cytoskeleton organization
BP	IDA	GO:0007026	negative regulation of microtubule depolymerization
BP	ISS	GO:0007224	smoothened signaling pathway
BP	IBA	GO:0018105	peptidyl-serine phosphorylation
BP	IDA	GO:0018105	peptidyl-serine phosphorylation
BP	ISS	GO:0021549	cerebellum development
BP	ISS	GO:0021681	cerebellar granular layer development
BP	ISS	GO:0021935	cerebellar granule cell precursor tangential migration
BP	IGI	GO:0030334	regulation of cell migration
BP	IMP	GO:0060271	cilium assembly
BP	ISS	GO:0060271	cilium assembly
BP	TAS	GO:0097711	ciliary basal body-plasma membrane docking
BP	IMP	GO:1902817	negative regulation of protein localization to microtubule
BP	IDA	GO:1904527	negative regulation of microtubule binding

Gene expression in normal tissue: TTBK2

Select Project:

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in TTBK2

Database	Pathway ID	Pathway Des.
reactome	R-HSA-1852241	Organelle biogenesis and maintenance
reactome	R-HSA-5617833	Cilium Assembly
reactome	R-HSA-5620912	Anchoring of the basal body to the plasma membrane

Gene-Drug: Aster Plot

Drug ID	Drug Name	Model Num.
iGMDRD280	CYTOCHALASIN B	3
iGMDRD123	Isoevodiamine	3
iGMDRD901	ELCPK	3
iGMDRD634	SCHEMBL2608041	6
iGMDRD85	Ursolic acid	3
iGMDRD193	Fqi1	3
iGMDRD639	YK 4-279	3
iGMDRD427	ABT737	2
iGMDRD532	Olaparib	3
iGMDRD150	RITA	2
iGMDRD701	NVP-AUY922	3
iGMDRD781	Sirolimus	3
iGMDRD126	Tipifarnib	5
iGMDRD772	BRD4770	3
iGMDRD512	nutlin 3	3
iGMDRD64	Parbendazole	3
iGMDRD552	AZD-1775	2
iGMDRD246	NPC26	3
iGMDRD886	Compound 1541A	2
iGMDRD300	Tozasertib	3
iGMDRD74	Idarubicin	6
iGMDRD286	Nsc 632839	6
iGMDRD188	Piperlongumine	3
iGMDRD562	Navitoclax	3
iGMDRD506	Fedratinib	4
iGMDRD434	BMS-536924	2
iGMDRD782	DC-45-A2	3
iGMDRD441	TW 37	3
iGMDRD137	Indisulam	3
iGMDRD158	NSC141540	3

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in TTBK2

SITE

DATATYPES

CLASSFICATION

Disclaimer: iGMDR is intended for research purposes only. Its information cannot be used for emergencies or medical or professional advice.