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GSK3A

Summary: This gene encodes a multifunctional Ser/Thr protein kinase that is implicated in the control of several regulatory proteins including glycogen synthase, and transcription factors, such as JUN. It also plays a role in the WNT and PI3K signaling pathways, as well as regulates the production of beta-amyloid peptides associated with Alzheimer's disease. [provided by RefSeq, Oct 2011].

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Name	OMIM ID	Ensembl ID	HGNC ID	PHARMGKB ID	Map Location
Nameglycogen synthase kinase 3 alpha OMIM IDMIM:606784 Ensembl IDEnsembl:ENSG00000105723 HGNC IDHGNC:HGNC:4616 PHARMGKB IDPA29008 Map Location19q13.2

Gene Categories:

DRUGGABLE GENOME KINASE SERINE THREONINE KINASE

GO terms in GSK3A

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Term Type	Evidence Type	GO Term ID	GO Des.
CC	IEA	GO:0005739	mitochondrion
CC	TAS	GO:0005829	cytosol
CC	IEA	GO:0005874	microtubule
CC	NAS	GO:0030877	beta-catenin destruction complex
CC	TAS	GO:0030877	beta-catenin destruction complex
CC	NAS	GO:0043025	neuronal cell body

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Gene expression in normal tissue: GSK3A

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Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in GSK3A

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Database	Pathway ID	Pathway Des.
wikipathways	WP127	IL-5 Signaling Pathway
wikipathways	WP1982	Sterol Regulatory Element-Binding Proteins (SREBP) signalling
wikipathways	WP2034	Leptin signaling pathway
wikipathways	WP23	B Cell Receptor Signaling Pathway
wikipathways	WP2583	T-Cell Receptor and Co-stimulatory Signaling
wikipathways	WP2593	JAK-STAT

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Gene-Drug: Aster Plot

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Drug ID	Drug Name	Model Num.
iGMDRD329	Merck60	4
iGMDRD74	Idarubicin	7
iGMDRD887	Compound 23 citrate	4
iGMDRD356	PNU-74654	1

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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in GSK3A

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	Model	Level	Reference ID	Tissue	Cancer	Drug	Clinical Response	Source
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