GSK3A
Summary: This gene encodes a multifunctional Ser/Thr protein kinase that is implicated in the control of several regulatory proteins including glycogen synthase, and transcription factors, such as JUN. It also plays a role in the WNT and PI3K signaling pathways, as well as regulates the production of beta-amyloid peptides associated with Alzheimer's disease. [provided by RefSeq, Oct 2011].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| glycogen synthase kinase 3 alpha | MIM:606784 | Ensembl:ENSG00000105723 | HGNC:HGNC:4616 | PA29008 | 19q13.2 |
GO terms in GSK3A
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IEA | GO:0005739 | mitochondrion |
| CC | TAS | GO:0005829 | cytosol |
| CC | IEA | GO:0005874 | microtubule |
| CC | NAS | GO:0030877 | beta-catenin destruction complex |
| CC | TAS | GO:0030877 | beta-catenin destruction complex |
| CC | NAS | GO:0043025 | neuronal cell body |
| CC | NAS | GO:0097440 | apical dendrite |
| CC | IEA | GO:0098794 | postsynapse |
| CC | NAS | GO:1990635 | proximal dendrite |
| BP | ISS | GO:0003073 | regulation of systemic arterial blood pressure |
| BP | ISS | GO:0003214 | cardiac left ventricle morphogenesis |
| BP | IEA | GO:0005977 | glycogen metabolic process |
| BP | IEA | GO:0006349 | regulation of gene expression by genetic imprinting |
| BP | IDA | GO:0006468 | protein phosphorylation |
| BP | NAS | GO:0007212 | dopamine receptor signaling pathway |
| BP | IEA | GO:0007568 | aging |
| BP | ISS | GO:0008286 | insulin receptor signaling pathway |
| BP | ISS | GO:0010628 | positive regulation of gene expression |
| BP | IEA | GO:0010800 | positive regulation of peptidyl-threonine phosphorylation |
| BP | IC | GO:0010905 | negative regulation of UDP-glucose catabolic process |
| BP | IEA | GO:0016055 | Wnt signaling pathway |
| BP | IEA | GO:0016477 | cell migration |
| BP | IEA | GO:0018105 | peptidyl-serine phosphorylation |
| BP | IDA | GO:0018107 | peptidyl-threonine phosphorylation |
| BP | IMP | GO:0031398 | positive regulation of protein ubiquitination |
| BP | ISS | GO:0032007 | negative regulation of TOR signaling |
| BP | IMP | GO:0032436 | positive regulation of proteasomal ubiquitin-dependent protein catabolic process |
| BP | IMP | GO:0032869 | cellular response to insulin stimulus |
| BP | IEA | GO:0033138 | positive regulation of peptidyl-serine phosphorylation |
| BP | ISS | GO:0036016 | cellular response to interleukin-3 |
| BP | TAS | GO:0036498 | IRE1-mediated unfolded protein response |
| BP | ISS | GO:0043161 | proteasome-mediated ubiquitin-dependent protein catabolic process |
| BP | IEA | GO:0043525 | positive regulation of neuron apoptotic process |
| BP | IEA | GO:0044027 | hypermethylation of CpG island |
| BP | TAS | GO:0045719 | negative regulation of glycogen biosynthetic process |
| BP | NAS | GO:0045732 | positive regulation of protein catabolic process |
| BP | ISS | GO:0045823 | positive regulation of heart contraction |
| BP | IEA | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| BP | IMP | GO:0046325 | negative regulation of glucose import |
| BP | IMP | GO:0046627 | negative regulation of insulin receptor signaling pathway |
| BP | NAS | GO:0060079 | excitatory postsynaptic potential |
| BP | ISS | GO:0061052 | negative regulation of cell growth involved in cardiac muscle cell development |
| BP | IEA | GO:0071285 | cellular response to lithium ion |
| BP | IEA | GO:0071407 | cellular response to organic cyclic compound |
| BP | ISS | GO:0071879 | positive regulation of adenylate cyclase-activating adrenergic receptor signaling pathway |
| BP | TAS | GO:0090090 | negative regulation of canonical Wnt signaling pathway |
| BP | ISS | GO:0097191 | extrinsic apoptotic signaling pathway |
| BP | ISS | GO:0097192 | extrinsic apoptotic signaling pathway in absence of ligand |
| BP | ISS | GO:0106071 | positive regulation of adenylate cyclase-activating G-protein coupled receptor signaling pathway |
| BP | ISS | GO:1901030 | positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway |
| BP | IGI | GO:1902004 | positive regulation of amyloid-beta formation |
| BP | IMP | GO:1902004 | positive regulation of amyloid-beta formation |
| BP | IMP | GO:1903146 | regulation of autophagy of mitochondrion |
| BP | IMP | GO:1903955 | positive regulation of protein targeting to mitochondrion |
| BP | IMP | GO:1904227 | negative regulation of glycogen synthase activity, transferring glucose-1-phosphate |
| BP | TAS | GO:2000077 | negative regulation of type B pancreatic cell development |
| BP | IEA | GO:2000171 | negative regulation of dendrite development |
| BP | TAS | GO:2000466 | negative regulation of glycogen (starch) synthase activity |
| BP | ISS | GO:2000467 | positive regulation of glycogen (starch) synthase activity |
| MF | IDA | GO:0004674 | protein serine/threonine kinase activity |
| MF | NAS | GO:0004674 | protein serine/threonine kinase activity |
| MF | IPI | GO:0005102 | signaling receptor binding |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0005524 | ATP binding |
| MF | IPI | GO:0034236 | protein kinase A catalytic subunit binding |
| MF | TAS | GO:0050321 | tau-protein kinase activity |
Gene expression in normal tissue: GSK3A
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in GSK3A
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| wikipathways | WP127 | IL-5 Signaling Pathway |
| wikipathways | WP1982 | Sterol Regulatory Element-Binding Proteins (SREBP) signalling |
| wikipathways | WP2034 | Leptin signaling pathway |
| wikipathways | WP23 | B Cell Receptor Signaling Pathway |
| wikipathways | WP2583 | T-Cell Receptor and Co-stimulatory Signaling |
| wikipathways | WP2593 | JAK-STAT |
| wikipathways | WP3295 | Chemical Compounds to monitor Proteins |
| wikipathways | WP3472 | XBP1(S) activates chaperone genes |
| wikipathways | WP363 | Wnt Signaling Pathway |
| wikipathways | WP3872 | Regulation of Apoptosis by Parathyroid Hormone-related Protein |
| wikipathways | WP3915 | Angiopoietin Like Protein 8 Regulatory Pathway |
| wikipathways | WP481 | Insulin Signaling |
| wikipathways | WP500 | Glycogen Metabolism |
| netpath | Pathway_BCR | BCR |
| netpath | Pathway_EGFR1 | EGFR1 |
| netpath | Pathway_Ghrelin | Ghrelin |
| netpath | Pathway_IL-7 | IL-7 |
| netpath | Pathway_IL3 | IL3 |
| netpath | Pathway_IL5 | IL5 |
| netpath | Pathway_Leptin | Leptin |
| netpath | Pathway_Wnt | Wnt |
| pid | betacatenin_deg_pathway | Degradation of beta catenin |
| pid | foxm1pathway | FOXM1 transcription factor network |
| pid | pi3kciaktpathway | Class I PI3K signaling events mediated by Akt |
| pid | wnt_canonical_pathway | Canonical Wnt signaling pathway |
| kegg | hsa04062 | Chemokine signaling pathway - Homo sapiens (human) |
| kegg | hsa04728 | Dopaminergic synapse - Homo sapiens (human) |
| kegg | hsa04932 | Non-alcoholic fatty liver disease (NAFLD) - Homo sapiens (human) |
| biocarta | ptdinspathway | phosphoinositides and their downstream targets |
| reactome | R-HSA-1257604 | PIP3 activates AKT signaling |
| reactome | R-HSA-162582 | Signal Transduction |
| reactome | R-HSA-1643685 | Disease |
| reactome | R-HSA-198323 | AKT phosphorylates targets in the cytosol |
| reactome | R-HSA-2219528 | PI3K/AKT Signaling in Cancer |
| reactome | R-HSA-381038 | XBP1(S) activates chaperone genes |
| reactome | R-HSA-381070 | IRE1alpha activates chaperones |
| reactome | R-HSA-381119 | Unfolded Protein Response (UPR) |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-5663202 | Diseases of signal transduction |
| reactome | R-HSA-5674400 | Constitutive Signaling by AKT1 E17K in Cancer |
| reactome | R-HSA-9006925 | Intracellular signaling by second messengers |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD329 | Merck60 | 4 |
| iGMDRD74 | Idarubicin | 7 |
| iGMDRD887 | Compound 23 citrate | 4 |
| iGMDRD356 | PNU-74654 | 1 |
| iGMDRD451 | Serdemetan | 8 |
| iGMDRD802 | 4-methylfasudil | 3 |
| iGMDRD158 | NSC141540 | 8 |
| iGMDRD137 | Indisulam | 4 |
| iGMDRD801 | 2,4-dideoxy-DC-45-A2 | 4 |
| iGMDRD187 | BRD9876 | 2 |
| iGMDRD294 | Batimastat | 4 |
| iGMDRD171 | Pemetrexed | 1 |
| iGMDRD314 | Tanespimycin | 7 |
| iGMDRD375 | GW-405833 | 4 |
| iGMDRD154 | NSC23766 | 8 |
| iGMDRD280 | CYTOCHALASIN B | 4 |
| iGMDRD177 | Teniposide | 1 |
| iGMDRD512 | nutlin 3 | 4 |
| iGMDRD405 | PIK-75 | 4 |
| iGMDRD427 | ABT737 | 4 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in GSK3A
CLASSFICATION
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