DHDDS


Summary: The protein encoded by this gene catalyzes cis-prenyl chain elongation to produce the polyprenyl backbone of dolichol, a glycosyl carrier lipid required for the biosynthesis of several classes of glycoproteins. Mutations in this gene are associated with retinitis pigmentosa type 59. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
dehydrodolichyl diphosphate synthase subunitMIM:608172Ensembl:ENSG00000117682HGNC:HGNC:20603PA1348671191p36.11

GO terms in DHDDS


Term TypeEvidence TypeGO Term IDGO Des.
CCIBAGO:0005783endoplasmic reticulum
CCTASGO:0005789endoplasmic reticulum membrane
BPIEAGO:0006486protein glycosylation
BPIBAGO:0016094polyprenol biosynthetic process
MFIBAGO:0002094polyprenyltransferase activity
MFIDAGO:0002094polyprenyltransferase activity
MFIPIGO:0005515protein binding

Gene expression in normal tissue: DHDDS

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in DHDDS


DatabasePathway IDPathway Des.
kegghsa00900Terpenoid backbone biosynthesis - Homo sapiens (human)
humancycPWY-6129dolichol and dolichyl phosphate biosynthesis
reactomeR-HSA-1643685Disease
reactomeR-HSA-3781865Diseases of glycosylation
reactomeR-HSA-392499Metabolism of proteins
reactomeR-HSA-446193Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
reactomeR-HSA-446199Synthesis of Dolichyl-phosphate
reactomeR-HSA-446203Asparagine N-linked glycosylation
reactomeR-HSA-446219Synthesis of substrates in N-glycan biosythesis
reactomeR-HSA-4755609Defective DHDDS causes retinitis pigmentosa 59
reactomeR-HSA-5609975Diseases associated with glycosylation precursor biosynthesis
reactomeR-HSA-597592Post-translational protein modification

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD351GW843682X4
iGMDRD698Neratinib1
iGMDRD499PDMP3
iGMDRD237ABT-7512
iGMDRD341Triacsin c3
iGMDRD357AG 143613
iGMDRD132(-)-gallocatechin-3-O-gallate3
iGMDRD901ELCPK3
iGMDRD123Isoevodiamine3
iGMDRD584VER 1550083
iGMDRD512nutlin 31
iGMDRD583LDN 1931892
iGMDRD150RITA1
iGMDRD329Merck601
iGMDRD414MST-3122
iGMDRD871BRD63683
iGMDRD77Itraconazole3
iGMDRD434BMS-5369243
iGMDRD639YK 4-2791
iGMDRD193Fqi13
iGMDRD446LY 21832403
iGMDRD1008SR-II-138A1
iGMDRD420Leucascandrolide A2
iGMDRD151CHM-13
iGMDRD427ABT7376
iGMDRD144NSC953973
iGMDRD577BIX012943
iGMDRD506Fedratinib6
iGMDRD887Compound 23 citrate6
iGMDRD74Idarubicin3
iGMDRD451Serdemetan3
iGMDRD64Parbendazole3
iGMDRD138PX 123
iGMDRD782DC-45-A24

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in DHDDS

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