DHDDS
Summary: The protein encoded by this gene catalyzes cis-prenyl chain elongation to produce the polyprenyl backbone of dolichol, a glycosyl carrier lipid required for the biosynthesis of several classes of glycoproteins. Mutations in this gene are associated with retinitis pigmentosa type 59. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Aug 2011].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| dehydrodolichyl diphosphate synthase subunit | MIM:608172 | Ensembl:ENSG00000117682 | HGNC:HGNC:20603 | PA134867119 | 1p36.11 |
GO terms in DHDDS
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | IBA | GO:0005783 | endoplasmic reticulum |
| CC | TAS | GO:0005789 | endoplasmic reticulum membrane |
| BP | IEA | GO:0006486 | protein glycosylation |
| BP | IBA | GO:0016094 | polyprenol biosynthetic process |
| MF | IBA | GO:0002094 | polyprenyltransferase activity |
| MF | IDA | GO:0002094 | polyprenyltransferase activity |
| MF | IPI | GO:0005515 | protein binding |
Gene expression in normal tissue: DHDDS
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in DHDDS
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa00900 | Terpenoid backbone biosynthesis - Homo sapiens (human) |
| humancyc | PWY-6129 | dolichol and dolichyl phosphate biosynthesis |
| reactome | R-HSA-1643685 | Disease |
| reactome | R-HSA-3781865 | Diseases of glycosylation |
| reactome | R-HSA-392499 | Metabolism of proteins |
| reactome | R-HSA-446193 | Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein |
| reactome | R-HSA-446199 | Synthesis of Dolichyl-phosphate |
| reactome | R-HSA-446203 | Asparagine N-linked glycosylation |
| reactome | R-HSA-446219 | Synthesis of substrates in N-glycan biosythesis |
| reactome | R-HSA-4755609 | Defective DHDDS causes retinitis pigmentosa 59 |
| reactome | R-HSA-5609975 | Diseases associated with glycosylation precursor biosynthesis |
| reactome | R-HSA-597592 | Post-translational protein modification |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD351 | GW843682X | 4 |
| iGMDRD698 | Neratinib | 1 |
| iGMDRD499 | PDMP | 3 |
| iGMDRD237 | ABT-751 | 2 |
| iGMDRD341 | Triacsin c | 3 |
| iGMDRD357 | AG 14361 | 3 |
| iGMDRD132 | (-)-gallocatechin-3-O-gallate | 3 |
| iGMDRD901 | ELCPK | 3 |
| iGMDRD123 | Isoevodiamine | 3 |
| iGMDRD584 | VER 155008 | 3 |
| iGMDRD512 | nutlin 3 | 1 |
| iGMDRD583 | LDN 193189 | 2 |
| iGMDRD150 | RITA | 1 |
| iGMDRD329 | Merck60 | 1 |
| iGMDRD414 | MST-312 | 2 |
| iGMDRD871 | BRD6368 | 3 |
| iGMDRD77 | Itraconazole | 3 |
| iGMDRD434 | BMS-536924 | 3 |
| iGMDRD639 | YK 4-279 | 1 |
| iGMDRD193 | Fqi1 | 3 |
| iGMDRD446 | LY 2183240 | 3 |
| iGMDRD1008 | SR-II-138A | 1 |
| iGMDRD420 | Leucascandrolide A | 2 |
| iGMDRD151 | CHM-1 | 3 |
| iGMDRD427 | ABT737 | 6 |
| iGMDRD144 | NSC95397 | 3 |
| iGMDRD577 | BIX01294 | 3 |
| iGMDRD506 | Fedratinib | 6 |
| iGMDRD887 | Compound 23 citrate | 6 |
| iGMDRD74 | Idarubicin | 3 |
| iGMDRD451 | Serdemetan | 3 |
| iGMDRD64 | Parbendazole | 3 |
| iGMDRD138 | PX 12 | 3 |
| iGMDRD782 | DC-45-A2 | 4 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in DHDDS
CLASSFICATION
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