LDHA


Summary: The protein encoded by this gene catalyzes the conversion of L-lactate and NAD to pyruvate and NADH in the final step of anaerobic glycolysis. The protein is found predominantly in muscle tissue and belongs to the lactate dehydrogenase family. Mutations in this gene have been linked to exertional myoglobinuria. Multiple transcript variants encoding different isoforms have been found for this gene. The human genome contains several non-transcribed pseudogenes of this gene. [provided by RefSeq, Sep 2008].

NameOMIM IDEnsembl IDHGNC IDPHARMGKB IDMap Location
lactate dehydrogenase AMIM:150000Ensembl:ENSG00000134333HGNC:HGNC:6535PA3031911p15.1

GO terms in LDHA


Term TypeEvidence TypeGO Term IDGO Des.
CCHDAGO:0005634nucleus
CCTASGO:0005829cytosol
CCHDAGO:0016020membrane
CCHDAGO:0070062extracellular exosome
BPIEAGO:0001666response to hypoxia
BPIEAGO:0006089lactate metabolic process
BPTASGO:0006090pyruvate metabolic process
BPNASGO:0006096glycolytic process
BPIEAGO:0007584response to nutrient
BPIEAGO:0009749response to glucose
BPIEAGO:0019674NAD metabolic process
BPIEAGO:0042542response to hydrogen peroxide
BPIEAGO:0043065positive regulation of apoptotic process
BPIEAGO:0043627response to estrogen
BPIEAGO:0048569post-embryonic animal organ development
BPIEAGO:0051591response to cAMP
BPIEAGO:0055114oxidation-reduction process
MFEXPGO:0004459L-lactate dehydrogenase activity
MFNASGO:0004459L-lactate dehydrogenase activity
MFIPIGO:0005515protein binding
MFIEAGO:0019900kinase binding
MFIEAGO:0042802identical protein binding
MFHDAGO:0045296cadherin binding
MFIEAGO:0051287NAD binding

Gene expression in normal tissue: LDHA

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

Pathways in LDHA


DatabasePathway IDPathway Des.
kegghsa00010Glycolysis / Gluconeogenesis - Homo sapiens (human)
kegghsa00270Cysteine and methionine metabolism - Homo sapiens (human)
kegghsa00620Pyruvate metabolism - Homo sapiens (human)
kegghsa00640Propanoate metabolism - Homo sapiens (human)
kegghsa04066HIF-1 signaling pathway - Homo sapiens (human)
kegghsa04922Glucagon signaling pathway - Homo sapiens (human)
kegghsa05230Central carbon metabolism in cancer - Homo sapiens (human)
humancycPWY-5481lactate fermentation (reoxidation of cytosolic NADH)
netpathPathway_EGFR1EGFR1
netpathPathway_TCRTCR
reactomeR-HSA-1428517The citric acid (TCA) cycle and respiratory electron transport
reactomeR-HSA-1430728Metabolism
reactomeR-HSA-70268Pyruvate metabolism
reactomeR-HSA-71406Pyruvate metabolism and Citric Acid (TCA) cycle
biocartahifpathwayhypoxia-inducible factor in the cardivascular system
pidhif1_tfpathwayHIF-1-alpha transcription factor network
pidmyc_activpathwayValidated targets of C-MYC transcriptional activation
smpdbSMP02298Glutaminolysis and Cancer
wikipathwaysWP1946Cori Cycle
wikipathwaysWP2456HIF1A and PPARG regulation of glycolysis
wikipathwaysWP3614Photodynamic therapy-induced HIF-1 survival signaling
wikipathwaysWP3925Amino Acid metabolism
wikipathwaysWP3961fig-met-1-last-solution
wikipathwaysWP4018Pathways in clear cell renal cell carcinoma
wikipathwaysWP4141PI3K-AKT-mTOR - VitD3 Signalling
wikipathwaysWP4206Hereditary Leiomyomatosis and Renal Cell Carcinoma Pathway
wikipathwaysWP534Glycolysis and Gluconeogenesis

Gene-Drug: Aster Plot


Drug IDDrug NameModel Num.
iGMDRD329Merck606
iGMDRD286Nsc 6328392
iGMDRD367Ro 28-16753
iGMDRD871BRD63682
iGMDRD82Quiflapon3
iGMDRD552AZD-17753
iGMDRD263AACOCF33
iGMDRD147Prima-11
iGMDRD300Tozasertib1
iGMDRD5Tyrphostin AG 14785
iGMDRD158NSC1415403
iGMDRD220fumonisin B11
iGMDRD202Curcumin3
iGMDRD251ML1623
iGMDRD271Brefeldin A3
iGMDRD213SMR0000686502
iGMDRD481Dactolisib1
iGMDRD6AM-5802
iGMDRD289Parthenolide3
iGMDRD698Neratinib6
iGMDRD314Tanespimycin3
iGMDRD132(-)-gallocatechin-3-O-gallate4
iGMDRD154NSC237663
iGMDRD177Teniposide2
iGMDRD211(1S,3R)-RSL32
iGMDRD607Ubistatin B2
iGMDRD512nutlin 31
iGMDRD486Tosedostat3
iGMDRD48Dexamethasone2
iGMDRD405PIK-753
iGMDRD523Cyanoquinoline, 113
iGMDRD532Olaparib2
iGMDRD562Navitoclax3
iGMDRD780PP-302
iGMDRD888Compound 443
iGMDRD577BIX012942
iGMDRD74Idarubicin6
iGMDRD451Serdemetan3
iGMDRD60Quinoclamine3
iGMDRD690PRIMA-1MET2
iGMDRD8024-methylfasudil3
iGMDRD294Batimastat2
iGMDRD8012,4-dideoxy-DC-45-A22
iGMDRD226ML0063
iGMDRD318PAC-11
iGMDRD171Pemetrexed2
iGMDRD2PK-111951
iGMDRD375GW-4058332
iGMDRD280CYTOCHALASIN B2
iGMDRD425ERASTIN2
iGMDRD772BRD47702
iGMDRD889Compound 7d-cis2
iGMDRD126Tipifarnib2
iGMDRD781Sirolimus7
iGMDRD144NSC953973
iGMDRD670ML 2102

Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in LDHA

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