LDHA
Summary: The protein encoded by this gene catalyzes the conversion of L-lactate and NAD to pyruvate and NADH in the final step of anaerobic glycolysis. The protein is found predominantly in muscle tissue and belongs to the lactate dehydrogenase family. Mutations in this gene have been linked to exertional myoglobinuria. Multiple transcript variants encoding different isoforms have been found for this gene. The human genome contains several non-transcribed pseudogenes of this gene. [provided by RefSeq, Sep 2008].
Loading, please wait...
Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
---|---|---|---|---|---|
OMIM IDMIM:150000 Ensembl IDEnsembl:ENSG00000134333 HGNC IDHGNC:HGNC:6535 PHARMGKB IDPA30319 Map Location11p15.1 |
GO terms in LDHA
Loading, please wait...
Term Type | Evidence Type | GO Term ID | GO Des. |
---|---|---|---|
CC | HDA | GO:0005634 | nucleus |
CC | TAS | GO:0005829 | cytosol |
CC | HDA | GO:0016020 | membrane |
CC | HDA | GO:0070062 | extracellular exosome |
BP | IEA | GO:0001666 | response to hypoxia |
BP | IEA | GO:0006089 | lactate metabolic process |
Gene expression in normal tissue: LDHA
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in LDHA
Loading, please wait...
Database | Pathway ID | Pathway Des. |
---|---|---|
kegg | hsa00010 | Glycolysis / Gluconeogenesis - Homo sapiens (human) |
kegg | hsa00270 | Cysteine and methionine metabolism - Homo sapiens (human) |
kegg | hsa00620 | Pyruvate metabolism - Homo sapiens (human) |
kegg | hsa00640 | Propanoate metabolism - Homo sapiens (human) |
kegg | hsa04066 | HIF-1 signaling pathway - Homo sapiens (human) |
kegg | hsa04922 | Glucagon signaling pathway - Homo sapiens (human) |
Gene-Drug: Aster Plot
Gene in drug-gene network: Network Plot

Gene-drug targets distribution
Gene Structure: PDB
Models in LDHA
Loading, please wait...
Model | Level | Reference ID | Tissue | Cancer | Drug | Clinical Response | Source | |
---|---|---|---|---|---|---|---|---|
No matching records found |