LDHA
Summary: The protein encoded by this gene catalyzes the conversion of L-lactate and NAD to pyruvate and NADH in the final step of anaerobic glycolysis. The protein is found predominantly in muscle tissue and belongs to the lactate dehydrogenase family. Mutations in this gene have been linked to exertional myoglobinuria. Multiple transcript variants encoding different isoforms have been found for this gene. The human genome contains several non-transcribed pseudogenes of this gene. [provided by RefSeq, Sep 2008].
| Name | OMIM ID | Ensembl ID | HGNC ID | PHARMGKB ID | Map Location |
|---|---|---|---|---|---|
| lactate dehydrogenase A | MIM:150000 | Ensembl:ENSG00000134333 | HGNC:HGNC:6535 | PA30319 | 11p15.1 |
GO terms in LDHA
| Term Type | Evidence Type | GO Term ID | GO Des. |
|---|---|---|---|
| CC | HDA | GO:0005634 | nucleus |
| CC | TAS | GO:0005829 | cytosol |
| CC | HDA | GO:0016020 | membrane |
| CC | HDA | GO:0070062 | extracellular exosome |
| BP | IEA | GO:0001666 | response to hypoxia |
| BP | IEA | GO:0006089 | lactate metabolic process |
| BP | TAS | GO:0006090 | pyruvate metabolic process |
| BP | NAS | GO:0006096 | glycolytic process |
| BP | IEA | GO:0007584 | response to nutrient |
| BP | IEA | GO:0009749 | response to glucose |
| BP | IEA | GO:0019674 | NAD metabolic process |
| BP | IEA | GO:0042542 | response to hydrogen peroxide |
| BP | IEA | GO:0043065 | positive regulation of apoptotic process |
| BP | IEA | GO:0043627 | response to estrogen |
| BP | IEA | GO:0048569 | post-embryonic animal organ development |
| BP | IEA | GO:0051591 | response to cAMP |
| BP | IEA | GO:0055114 | oxidation-reduction process |
| MF | EXP | GO:0004459 | L-lactate dehydrogenase activity |
| MF | NAS | GO:0004459 | L-lactate dehydrogenase activity |
| MF | IPI | GO:0005515 | protein binding |
| MF | IEA | GO:0019900 | kinase binding |
| MF | IEA | GO:0042802 | identical protein binding |
| MF | HDA | GO:0045296 | cadherin binding |
| MF | IEA | GO:0051287 | NAD binding |
Gene expression in normal tissue: LDHA
Gene-model tissue-cancer distribution: Bubble Plot
Gene-drug pathway distribution
Pathways in LDHA
| Database | Pathway ID | Pathway Des. |
|---|---|---|
| kegg | hsa00010 | Glycolysis / Gluconeogenesis - Homo sapiens (human) |
| kegg | hsa00270 | Cysteine and methionine metabolism - Homo sapiens (human) |
| kegg | hsa00620 | Pyruvate metabolism - Homo sapiens (human) |
| kegg | hsa00640 | Propanoate metabolism - Homo sapiens (human) |
| kegg | hsa04066 | HIF-1 signaling pathway - Homo sapiens (human) |
| kegg | hsa04922 | Glucagon signaling pathway - Homo sapiens (human) |
| kegg | hsa05230 | Central carbon metabolism in cancer - Homo sapiens (human) |
| humancyc | PWY-5481 | lactate fermentation (reoxidation of cytosolic NADH) |
| netpath | Pathway_EGFR1 | EGFR1 |
| netpath | Pathway_TCR | TCR |
| reactome | R-HSA-1428517 | The citric acid (TCA) cycle and respiratory electron transport |
| reactome | R-HSA-1430728 | Metabolism |
| reactome | R-HSA-70268 | Pyruvate metabolism |
| reactome | R-HSA-71406 | Pyruvate metabolism and Citric Acid (TCA) cycle |
| biocarta | hifpathway | hypoxia-inducible factor in the cardivascular system |
| pid | hif1_tfpathway | HIF-1-alpha transcription factor network |
| pid | myc_activpathway | Validated targets of C-MYC transcriptional activation |
| smpdb | SMP02298 | Glutaminolysis and Cancer |
| wikipathways | WP1946 | Cori Cycle |
| wikipathways | WP2456 | HIF1A and PPARG regulation of glycolysis |
| wikipathways | WP3614 | Photodynamic therapy-induced HIF-1 survival signaling |
| wikipathways | WP3925 | Amino Acid metabolism |
| wikipathways | WP3961 | fig-met-1-last-solution |
| wikipathways | WP4018 | Pathways in clear cell renal cell carcinoma |
| wikipathways | WP4141 | PI3K-AKT-mTOR - VitD3 Signalling |
| wikipathways | WP4206 | Hereditary Leiomyomatosis and Renal Cell Carcinoma Pathway |
| wikipathways | WP534 | Glycolysis and Gluconeogenesis |
Gene-Drug: Aster Plot
| Drug ID | Drug Name | Model Num. |
|---|---|---|
| iGMDRD329 | Merck60 | 6 |
| iGMDRD286 | Nsc 632839 | 2 |
| iGMDRD367 | Ro 28-1675 | 3 |
| iGMDRD871 | BRD6368 | 2 |
| iGMDRD82 | Quiflapon | 3 |
| iGMDRD552 | AZD-1775 | 3 |
| iGMDRD263 | AACOCF3 | 3 |
| iGMDRD147 | Prima-1 | 1 |
| iGMDRD300 | Tozasertib | 1 |
| iGMDRD5 | Tyrphostin AG 1478 | 5 |
| iGMDRD158 | NSC141540 | 3 |
| iGMDRD220 | fumonisin B1 | 1 |
| iGMDRD202 | Curcumin | 3 |
| iGMDRD251 | ML162 | 3 |
| iGMDRD271 | Brefeldin A | 3 |
| iGMDRD213 | SMR000068650 | 2 |
| iGMDRD481 | Dactolisib | 1 |
| iGMDRD6 | AM-580 | 2 |
| iGMDRD289 | Parthenolide | 3 |
| iGMDRD698 | Neratinib | 6 |
| iGMDRD314 | Tanespimycin | 3 |
| iGMDRD132 | (-)-gallocatechin-3-O-gallate | 4 |
| iGMDRD154 | NSC23766 | 3 |
| iGMDRD177 | Teniposide | 2 |
| iGMDRD211 | (1S,3R)-RSL3 | 2 |
| iGMDRD607 | Ubistatin B | 2 |
| iGMDRD512 | nutlin 3 | 1 |
| iGMDRD486 | Tosedostat | 3 |
| iGMDRD48 | Dexamethasone | 2 |
| iGMDRD405 | PIK-75 | 3 |
| iGMDRD523 | Cyanoquinoline, 11 | 3 |
| iGMDRD532 | Olaparib | 2 |
| iGMDRD562 | Navitoclax | 3 |
| iGMDRD780 | PP-30 | 2 |
| iGMDRD888 | Compound 44 | 3 |
| iGMDRD577 | BIX01294 | 2 |
| iGMDRD74 | Idarubicin | 6 |
| iGMDRD451 | Serdemetan | 3 |
| iGMDRD60 | Quinoclamine | 3 |
| iGMDRD690 | PRIMA-1MET | 2 |
| iGMDRD802 | 4-methylfasudil | 3 |
| iGMDRD294 | Batimastat | 2 |
| iGMDRD801 | 2,4-dideoxy-DC-45-A2 | 2 |
| iGMDRD226 | ML006 | 3 |
| iGMDRD318 | PAC-1 | 1 |
| iGMDRD171 | Pemetrexed | 2 |
| iGMDRD2 | PK-11195 | 1 |
| iGMDRD375 | GW-405833 | 2 |
| iGMDRD280 | CYTOCHALASIN B | 2 |
| iGMDRD425 | ERASTIN | 2 |
| iGMDRD772 | BRD4770 | 2 |
| iGMDRD889 | Compound 7d-cis | 2 |
| iGMDRD126 | Tipifarnib | 2 |
| iGMDRD781 | Sirolimus | 7 |
| iGMDRD144 | NSC95397 | 3 |
| iGMDRD670 | ML 210 | 2 |
Gene in drug-gene network: Network Plot
Gene-drug targets distribution
Gene Structure: PDB
Models in LDHA
CLASSFICATION
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