LDHA


Summary: The protein encoded by this gene catalyzes the conversion of L-lactate and NAD to pyruvate and NADH in the final step of anaerobic glycolysis. The protein is found predominantly in muscle tissue and belongs to the lactate dehydrogenase family. Mutations in this gene have been linked to exertional myoglobinuria. Multiple transcript variants encoding different isoforms have been found for this gene. The human genome contains several non-transcribed pseudogenes of this gene. [provided by RefSeq, Sep 2008].

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Name
OMIM ID
Ensembl ID
HGNC ID
PHARMGKB ID
Map Location
OMIM IDMIM:150000
PHARMGKB IDPA30319
Map Location11p15.1

GO terms in LDHA


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Term Type
Evidence Type
GO Term ID
GO Des.
CC HDA GO:0005634 nucleus
CC TAS GO:0005829 cytosol
CC HDA GO:0016020 membrane
CC HDA GO:0070062 extracellular exosome
BP IEA GO:0001666 response to hypoxia
BP IEA GO:0006089 lactate metabolic process
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Gene expression in normal tissue: LDHA

Gene-model tissue-cancer distribution: Bubble Plot

Gene-drug pathway distribution

undefined40Apoptosis regulation2Ferroptosis2p53 pathway1Mitosis1Leukocyte transendothelial migration1One carbon pool by folate1Longevity regulating pathway1Genome integrity1Neuroactive ligand-receptor interaction1

Pathways in LDHA


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Database
Pathway ID
Pathway Des.
kegg hsa00010 Glycolysis / Gluconeogenesis - Homo sapiens (human)
kegg hsa00270 Cysteine and methionine metabolism - Homo sapiens (human)
kegg hsa00620 Pyruvate metabolism - Homo sapiens (human)
kegg hsa00640 Propanoate metabolism - Homo sapiens (human)
kegg hsa04066 HIF-1 signaling pathway - Homo sapiens (human)
kegg hsa04922 Glucagon signaling pathway - Homo sapiens (human)
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Gene-Drug: Aster Plot


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Drug ID
Drug Name
Model Num.
iGMDRD329 Merck60 6
iGMDRD286 Nsc 632839 2
iGMDRD367 Ro 28-1675 3
iGMDRD871 BRD6368 2
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Gene in drug-gene network: Network Plot

Gene-drug targets distribution

Gene Structure: PDB

Models in LDHA

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Model
Level
Reference ID
Tissue
Cancer
Drug
Clinical Response
Source
No matching records found

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